Primary extramedullary plasmacytoma of the liver

B. Demirhan, C. Sökmensüer, H. Karakayali, Y. Güngen, A. Doǧan, M. Haberal

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Extramedullary plasmacytoma of the Liver is a rare tumour, only two cases of which have been reported so far. A third case arising in a 22 year old woman, who presented with abdominal pain and enlargement of the liver, is described. Ultrasound and a computed tomography scan showed a solitary hepatic mass, 12 cm diameter, involving both lobes of the liver. Serum immunoelectrophoresis revealed an IgG κ monoclonal gammopathy. Histologically, the tumour was composed of mature plasma cells with mild atypia. The plasma cells infiltrated the liver parenchyma and showed κ light chain restriction, The monoclonal nature of the tumour was also demonstrated by PCR amplification of the immunoglobulin heavy chain genes. There was no evidence of bone involvement and repeated bone marrow aspirates and biopsy specimens were normal. The patient was treated with eight courses of chemotherapy. One year after diagnosis, the patient is well, the size of the tumour has decreased and the paraproteinaemia has disappeared.

Original languageEnglish (US)
Pages (from-to)74-76
Number of pages3
JournalJournal of clinical pathology
Volume50
Issue number1
DOIs
StatePublished - 1997

Keywords

  • Extramedullary plasmacytoma
  • Liver

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Demirhan, B., Sökmensüer, C., Karakayali, H., Güngen, Y., Doǧan, A., & Haberal, M. (1997). Primary extramedullary plasmacytoma of the liver. Journal of clinical pathology, 50(1), 74-76. https://doi.org/10.1136/jcp.50.1.74