Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil

Steven Vernino; Diva R. Salomao; Thomas M. Habermann; Brian P. O'Neill

doi:10.1212/01.wnl.0000173031.56429.04

Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil

Steven Vernino, Diva R. Salomao, Thomas M. Habermann, Brian P. O'Neill

Research output: Contribution to journal › Article › peer-review

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Abstract

Mycophenolate mofetil (MM), an immunosuppressant used after organ transplantation, is also used for treatment of autoimmune myasthenia gravis (MG). A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment. Primary CNS lymphoma regressed on withdrawal of MM. Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders.

Original language	English (US)
Pages (from-to)	639-641
Number of pages	3
Journal	Neurology
Volume	65
Issue number	4
DOIs	https://doi.org/10.1212/01.wnl.0000173031.56429.04
State	Published - Aug 23 2005

ASJC Scopus subject areas

Clinical Neurology

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abstract = "Mycophenolate mofetil (MM), an immunosuppressant used after organ transplantation, is also used for treatment of autoimmune myasthenia gravis (MG). A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment. Primary CNS lymphoma regressed on withdrawal of MM. Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders.",

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AU - Vernino, Steven

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AU - Habermann, Thomas M.

AU - O'Neill, Brian P.

PY - 2005/8/23

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AB - Mycophenolate mofetil (MM), an immunosuppressant used after organ transplantation, is also used for treatment of autoimmune myasthenia gravis (MG). A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment. Primary CNS lymphoma regressed on withdrawal of MM. Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders.

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Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil

Abstract

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