Primary central nervous system lymphoma in a pediatric patient with acquired immune deficiency syndrome. Treatment with radiation therapy

J. Goldstein, Dennis W Dickson, A. Rubenstein, W. Woods, F. Mincer, A. L. Belman, L. Davis

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Primary central nervous system (CNS) lymphoma, an otherwise rare pediatric tumor, has been reported with increasing frequency in children with acquired immune deficiency syndrome (AIDS). With current therapy, the outcome of this disease is invariably fatal. The authors present a case of primary CNS lymphoma in a 3.5-year-old girl with AIDS who received treatment with total brain irradiation. After treatment, the patient's mental status improved, the seizures resolved, and she had no further progression of her neurologic symptoms until she died of pneumonia 6 months later. The autopsy revealed a necrotic mass at the site of the original tumor. The brain stem and spinal cord, unirradiated, contained lymphomatous lesions. The patient had extensive fibrinoid necrosis and leukoencephalopathy that were consistent with radiation-induced CNS damage. Coexisting AIDS encephalopathy also contributed to the patient's CNS injury. Effective palliation of CNS lymphoma in children with AIDS may be obtained with cranial irradiation. Pediatric AIDS patients may show more severe tissue effects from irradiation than unaffected children.

Original languageEnglish (US)
Pages (from-to)2503-2508
Number of pages6
JournalCancer
Volume66
Issue number12
DOIs
StatePublished - 1990
Externally publishedYes

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Lymphoma
Acquired Immunodeficiency Syndrome
Radiotherapy
Central Nervous System
Pediatrics
Cranial Irradiation
Nervous System Trauma
Therapeutics
Leukoencephalopathies
Mentally Ill Persons
Brain Diseases
Neurologic Manifestations
Brain Stem
Autopsy
Neoplasms
Spinal Cord
Pneumonia
Seizures
Necrosis
Radiation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Primary central nervous system lymphoma in a pediatric patient with acquired immune deficiency syndrome. Treatment with radiation therapy. / Goldstein, J.; Dickson, Dennis W; Rubenstein, A.; Woods, W.; Mincer, F.; Belman, A. L.; Davis, L.

In: Cancer, Vol. 66, No. 12, 1990, p. 2503-2508.

Research output: Contribution to journalArticle

Goldstein, J. ; Dickson, Dennis W ; Rubenstein, A. ; Woods, W. ; Mincer, F. ; Belman, A. L. ; Davis, L. / Primary central nervous system lymphoma in a pediatric patient with acquired immune deficiency syndrome. Treatment with radiation therapy. In: Cancer. 1990 ; Vol. 66, No. 12. pp. 2503-2508.
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