Primary central nervous system lymphoma can be histologically diagnosed after previous corticosteroid use

A pilot study to determine whether corticosteroids prevent the diagnosis of primary central nervous system lymphoma

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61 Citations (Scopus)

Abstract

The objective is to determine whether corticosteroid administration before biopsy prevents histopathological diagnosis of primary central nervous system lymphoma (PCNSL). A retrospective review was performed of immunocompetent PCNSL patients from 1985 to 2005. A total of 109 patients was identified. Sixty-eight (63.6%) patients received corticosteroids before diagnosis. Thirteen patients (of 109; 12%) had undergone repeat brain biopsy to confirm PCNSL. These included 8 (of 68) patients who had received corticosteroids (12%), and 5 (of 39) who had not (13%) (p = 1.0). The majority of PCNSL patients who received corticosteroids before diagnosis did not experience significant radiographic change or require second biopsy for diagnosis.

Original languageEnglish (US)
Pages (from-to)662-667
Number of pages6
JournalAnnals of Neurology
Volume63
Issue number5
DOIs
StatePublished - May 2008

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Lymphoma
Adrenal Cortex Hormones
Central Nervous System
Biopsy
Brain

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

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title = "Primary central nervous system lymphoma can be histologically diagnosed after previous corticosteroid use: A pilot study to determine whether corticosteroids prevent the diagnosis of primary central nervous system lymphoma",
abstract = "The objective is to determine whether corticosteroid administration before biopsy prevents histopathological diagnosis of primary central nervous system lymphoma (PCNSL). A retrospective review was performed of immunocompetent PCNSL patients from 1985 to 2005. A total of 109 patients was identified. Sixty-eight (63.6{\%}) patients received corticosteroids before diagnosis. Thirteen patients (of 109; 12{\%}) had undergone repeat brain biopsy to confirm PCNSL. These included 8 (of 68) patients who had received corticosteroids (12{\%}), and 5 (of 39) who had not (13{\%}) (p = 1.0). The majority of PCNSL patients who received corticosteroids before diagnosis did not experience significant radiographic change or require second biopsy for diagnosis.",
author = "{Porter Umphrey}, {Alyx B} and Caterina Giannini and Kaufmann, {Timothy J} and Lucchinetti, {Claudia F} and Wenting Wu and Decker, {Paul A.} and Atkinson, {John L D} and O'Neill, {Brian Patrick}",
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AU - Giannini, Caterina

AU - Kaufmann, Timothy J

AU - Lucchinetti, Claudia F

AU - Wu, Wenting

AU - Decker, Paul A.

AU - Atkinson, John L D

AU - O'Neill, Brian Patrick

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