Primary central nervous system lymphoma can be histologically diagnosed after previous corticosteroid use: A pilot study to determine whether corticosteroids prevent the diagnosis of primary central nervous system lymphoma

Alyx B. Porter; Caterina Giannini; Timothy Kaufmann; Claudia F. Lucchinetti; Wenting Wu; Paul A. Decker; John L.D. Atkinson; Brian Patrick O'Neill

doi:10.1002/ana.21366

Primary central nervous system lymphoma can be histologically diagnosed after previous corticosteroid use: A pilot study to determine whether corticosteroids prevent the diagnosis of primary central nervous system lymphoma

Alyx B. Porter, Caterina Giannini, Timothy Kaufmann, Claudia F. Lucchinetti, Wenting Wu, Paul A. Decker, John L.D. Atkinson, Brian Patrick O'Neill

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

The objective is to determine whether corticosteroid administration before biopsy prevents histopathological diagnosis of primary central nervous system lymphoma (PCNSL). A retrospective review was performed of immunocompetent PCNSL patients from 1985 to 2005. A total of 109 patients was identified. Sixty-eight (63.6%) patients received corticosteroids before diagnosis. Thirteen patients (of 109; 12%) had undergone repeat brain biopsy to confirm PCNSL. These included 8 (of 68) patients who had received corticosteroids (12%), and 5 (of 39) who had not (13%) (p = 1.0). The majority of PCNSL patients who received corticosteroids before diagnosis did not experience significant radiographic change or require second biopsy for diagnosis.

Original language	English (US)
Pages (from-to)	662-667
Number of pages	6
Journal	Annals of neurology
Volume	63
Issue number	5
DOIs	https://doi.org/10.1002/ana.21366
State	Published - May 2008

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Porter, A. B., Giannini, C., Kaufmann, T., Lucchinetti, C. F., Wu, W., Decker, P. A., Atkinson, J. L. D., & O'Neill, B. P. (2008). Primary central nervous system lymphoma can be histologically diagnosed after previous corticosteroid use: A pilot study to determine whether corticosteroids prevent the diagnosis of primary central nervous system lymphoma. Annals of neurology, 63(5), 662-667. https://doi.org/10.1002/ana.21366

Primary central nervous system lymphoma can be histologically diagnosed after previous corticosteroid use: A pilot study to determine whether corticosteroids prevent the diagnosis of primary central nervous system lymphoma. / Porter, Alyx B.; Giannini, Caterina ; Kaufmann, Timothy et al.
In: Annals of neurology, Vol. 63, No. 5, 05.2008, p. 662-667.

Research output: Contribution to journal › Article › peer-review

Porter, AB , Giannini, C , Kaufmann, T , Lucchinetti, CF, Wu, W, Decker, PA, Atkinson, JLD & O'Neill, BP 2008, 'Primary central nervous system lymphoma can be histologically diagnosed after previous corticosteroid use: A pilot study to determine whether corticosteroids prevent the diagnosis of primary central nervous system lymphoma', Annals of neurology, vol. 63, no. 5, pp. 662-667. https://doi.org/10.1002/ana.21366

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abstract = "The objective is to determine whether corticosteroid administration before biopsy prevents histopathological diagnosis of primary central nervous system lymphoma (PCNSL). A retrospective review was performed of immunocompetent PCNSL patients from 1985 to 2005. A total of 109 patients was identified. Sixty-eight (63.6%) patients received corticosteroids before diagnosis. Thirteen patients (of 109; 12%) had undergone repeat brain biopsy to confirm PCNSL. These included 8 (of 68) patients who had received corticosteroids (12%), and 5 (of 39) who had not (13%) (p = 1.0). The majority of PCNSL patients who received corticosteroids before diagnosis did not experience significant radiographic change or require second biopsy for diagnosis.",

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Primary central nervous system lymphoma can be histologically diagnosed after previous corticosteroid use: A pilot study to determine whether corticosteroids prevent the diagnosis of primary central nervous system lymphoma

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