Primary biliary cirrhosis: Dutch application of the Mayo Model before and after orthotopic liver transplantation

Gooitzen M. Van Dam, Bart W. Verbaan, Terry M. Therneau, E. Rolland Dickson, Michael Malinchoc, Paul A. Murtaugh, Johannus R. Huizenga, Chris H. Gips

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background/Aims: A retrospective study of primary biliary cirrhosis (PBC) was performed to study the Original Mayo Model for predicting survival by a Dutch data-set of patients, presentation of disease progression assessment of liver transplantation, prediction of post-transplantation survival; and the addition of two laboratory variables to the Original Mayo Model. Materials and Methods: Survival of 83 patients, 37 of whom underwent transplantation, were studied. Mean follow-up was 6.0 ± 0.45 SEM years. Risk score at diagnosis, platelet count, and serum sodium were analyzed in a Cox model. Results: The Original Mayo Model estimated survival for low-, medium-, and high-risk groups accurately and it also presented disease progression. Baseline Mayo risk score in a Cox model had a regression coefficient of 1.01, indicating an excellent predictor p < 0.0001. Platelet count was a predictor of survival (p < 0.002) whereas serum sodium did not (p = 0.67). A new model combined of the Original Mayo risk score and platelet count predicted survival in high-risk patients somewhat better compared to the Original Mayo Model. With both models, liver transplantation had a significant beneficial effect on survival (p < 0.001). The scores revealed no significant influence (p = 0.47) for overall post-transplantation survival. Conclusions: The Original Mayo Model remains the model of choice for patients with PBC for prognostication, from 3-8 years, is a useful tool in the assessment of liver transplantation but not an indicator of post-transplantation survival. Platelet count showed to have additional prognostic value. A new model combined of platelet count and the Original Mayo risk score did predict survival in high-risk groups slightly better compared to the Original Mayo Model.

Original languageEnglish (US)
Pages (from-to)732-743
Number of pages12
JournalHepato-Gastroenterology
Volume44
Issue number15
StatePublished - Jul 17 1997

Keywords

  • Disease progression
  • Original Mayo Model
  • Platelet count
  • Primary Biliary Cirrhosis
  • Prognosis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Van Dam, G. M., Verbaan, B. W., Therneau, T. M., Dickson, E. R., Malinchoc, M., Murtaugh, P. A., Huizenga, J. R., & Gips, C. H. (1997). Primary biliary cirrhosis: Dutch application of the Mayo Model before and after orthotopic liver transplantation. Hepato-Gastroenterology, 44(15), 732-743.