TY - JOUR
T1 - Primary and recurrent early stage laryngeal cancer
T2 - Preliminary results of 2-[fluorine 18]fluoro-2-deoxy-D-glucose pet imaging
AU - Lowe, Val J.
AU - Kim, Han
AU - Boyd, James H.
AU - Elsenbeis, John F.
AU - Dunphy, Frank R.
AU - Fletcher, James W.
PY - 1999/9
Y1 - 1999/9
N2 - PURPOSE: To evaluate the effectiveness of 2-[fluorine 18]fluoro-2-deoxy- D-glucose (FDG) positron emission tomography (PET) in the identification of early stage (T1-T2) primary and recurrent laryngeal cancer. MATERIALS AND METHODS: Twelve patients with T1 or T2 laryngeal cancer underwent imaging prospectively with PET. Seven patients had new disease, and five had recurrent disease. All patients underwent imaging prior to planned therapy and tissue biopsy. PET images were evaluated by using standardized uptake ratios and visual analysis. RESULTS: Histopathologic evidence of early stage cancer was documented in the 12 patients. One had a carcinoma in situ, nine had T1 tumors, and two had T2 tumors. Of the 12 patients, 10 had vocal cord tumors, one had a hypopharyngeal tumor, and one had a preepiglottic tumor. Eleven (92%) patients with early stage cancer had standardized uptake ratios indicative of malignancy (mean, 4.6; SD, 1.8; 95% CI, 1.2; range, 2.8-7.6). One had false-negative results (standardized uptake ratio = 2.3). Nine underwent CT, and results in the larynx were normal in seven and abnormal in two. CONCLUSION: FDG PET can be used to identify primary and recurrent early stage laryngeal cancer. It may be useful for follow-up after therapy.
AB - PURPOSE: To evaluate the effectiveness of 2-[fluorine 18]fluoro-2-deoxy- D-glucose (FDG) positron emission tomography (PET) in the identification of early stage (T1-T2) primary and recurrent laryngeal cancer. MATERIALS AND METHODS: Twelve patients with T1 or T2 laryngeal cancer underwent imaging prospectively with PET. Seven patients had new disease, and five had recurrent disease. All patients underwent imaging prior to planned therapy and tissue biopsy. PET images were evaluated by using standardized uptake ratios and visual analysis. RESULTS: Histopathologic evidence of early stage cancer was documented in the 12 patients. One had a carcinoma in situ, nine had T1 tumors, and two had T2 tumors. Of the 12 patients, 10 had vocal cord tumors, one had a hypopharyngeal tumor, and one had a preepiglottic tumor. Eleven (92%) patients with early stage cancer had standardized uptake ratios indicative of malignancy (mean, 4.6; SD, 1.8; 95% CI, 1.2; range, 2.8-7.6). One had false-negative results (standardized uptake ratio = 2.3). Nine underwent CT, and results in the larynx were normal in seven and abnormal in two. CONCLUSION: FDG PET can be used to identify primary and recurrent early stage laryngeal cancer. It may be useful for follow-up after therapy.
KW - Emission CT (ECT), comparative studies
KW - Fluorine, radioactive
KW - Head and neck neoplasms
KW - Head and neck neoplasms, emission CT (ECT)
KW - Larynx, neoplasms
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U2 - 10.1148/radiology.212.3.r99se26799
DO - 10.1148/radiology.212.3.r99se26799
M3 - Article
C2 - 10478249
AN - SCOPUS:0032826578
VL - 212
SP - 799
EP - 802
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 3
ER -