Prevention of sudden death in patients with coronary artery disease: The multicenter unsustained tachycardia trial (MUSTT)

Alfred E. Buxton; John D. Fisher; Mark E. Josephson; Kerry L. Lee; David B. Pryor; Eric N. Prystowsky; Michael B. Simson; Lorenzo DiCarlo; Debra S. Echt; Douglas Packer; G. Stephen Greer; Mario Talajic; MUSTT Investigators the MUSTT Investigators

doi:10.1016/0033-0620(93)90015-6

Prevention of sudden death in patients with coronary artery disease: The multicenter unsustained tachycardia trial (MUSTT)

Alfred E. Buxton, John D. Fisher, Mark E. Josephson, Kerry L. Lee, David B. Pryor, Eric N. Prystowsky, Michael B. Simson, Lorenzo DiCarlo, Debra S. Echt, Douglas Packer, G. Stephen Greer, Mario Talajic, MUSTT Investigators the MUSTT Investigators

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

133 Scopus citations

Abstract

This trial will significantly advance our understanding of the prognostic and therapeutic usefulness of electrophysiologic studies in patients with coronary artery disease. Several features of this trial are worth emphasizing. First, the protocol for performing programmed stimulation and serial drug testing is designed to mirror those currently in use by many practicing electrophysiologists. While practice patterns vary, the procedures used in the trial reflect what is considered "usual and standard" practice. Second, because half of the patients with inducible sustained ventricular tachycardia will be given no antiarrhythmic therapy, we will be able to ascertain the true risk of sudden death in this patient population without the influence of these agents. Third, this trial will assess the usefulness of a method of guiding antiarrhythmic therapy (electrophysiologic testing) to reduce mortality in this high-risk population. It will not evaluate the efficacy of a specific type of antiarrhythmic therapy.

Original language	English (US)
Pages (from-to)	215-226
Number of pages	12
Journal	Progress in Cardiovascular Diseases
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/0033-0620(93)90015-6
State	Published - 1993

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/0033-0620(93)90015-6

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Buxton, A. E., Fisher, J. D., Josephson, M. E., Lee, K. L., Pryor, D. B., Prystowsky, E. N., Simson, M. B., DiCarlo, L., Echt, D. S., Packer, D., Stephen Greer, G., Talajic, M., & the MUSTT Investigators, MUSTT. I. (1993). Prevention of sudden death in patients with coronary artery disease: The multicenter unsustained tachycardia trial (MUSTT). Progress in Cardiovascular Diseases, 36(3), 215-226. https://doi.org/10.1016/0033-0620(93)90015-6

Buxton, AE, Fisher, JD, Josephson, ME, Lee, KL, Pryor, DB, Prystowsky, EN, Simson, MB, DiCarlo, L, Echt, DS, Packer, D, Stephen Greer, G, Talajic, M & the MUSTT Investigators, MUSTTI 1993, 'Prevention of sudden death in patients with coronary artery disease: The multicenter unsustained tachycardia trial (MUSTT)', Progress in Cardiovascular Diseases, vol. 36, no. 3, pp. 215-226. https://doi.org/10.1016/0033-0620(93)90015-6

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abstract = "This trial will significantly advance our understanding of the prognostic and therapeutic usefulness of electrophysiologic studies in patients with coronary artery disease. Several features of this trial are worth emphasizing. First, the protocol for performing programmed stimulation and serial drug testing is designed to mirror those currently in use by many practicing electrophysiologists. While practice patterns vary, the procedures used in the trial reflect what is considered {"}usual and standard{"} practice. Second, because half of the patients with inducible sustained ventricular tachycardia will be given no antiarrhythmic therapy, we will be able to ascertain the true risk of sudden death in this patient population without the influence of these agents. Third, this trial will assess the usefulness of a method of guiding antiarrhythmic therapy (electrophysiologic testing) to reduce mortality in this high-risk population. It will not evaluate the efficacy of a specific type of antiarrhythmic therapy.",

author = "Buxton, {Alfred E.} and Fisher, {John D.} and Josephson, {Mark E.} and Lee, {Kerry L.} and Pryor, {David B.} and Prystowsky, {Eric N.} and Simson, {Michael B.} and Lorenzo DiCarlo and Echt, {Debra S.} and Douglas Packer and {Stephen Greer}, G. and Mario Talajic and {the MUSTT Investigators}, {MUSTT Investigators}",

note = "Funding Information: Supported by grants from the Nationul Heart. Lung and Blood Institute, Bethesda, MD. No. UOI HL 45700.OlA I. and No. UOI HL 45726OIAI.",

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doi = "10.1016/0033-0620(93)90015-6",

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AU - Stephen Greer, G.

AU - Talajic, Mario

AU - the MUSTT Investigators, MUSTT Investigators

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Prevention of sudden death in patients with coronary artery disease: The multicenter unsustained tachycardia trial (MUSTT)

Abstract

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