Prevention of sudden death in patients with coronary artery disease: The multicenter unsustained tachycardia trial (MUSTT)

Alfred E. Buxton, John D. Fisher, Mark E. Josephson, Kerry L. Lee, David B. Pryor, Eric N. Prystowsky, Michael B. Simson, Lorenzo DiCarlo, Debra S. Echt, Douglas Packer, G. Stephen Greer, Mario Talajic, MUSTT Investigators the MUSTT Investigators

Research output: Contribution to journalArticle

130 Scopus citations

Abstract

This trial will significantly advance our understanding of the prognostic and therapeutic usefulness of electrophysiologic studies in patients with coronary artery disease. Several features of this trial are worth emphasizing. First, the protocol for performing programmed stimulation and serial drug testing is designed to mirror those currently in use by many practicing electrophysiologists. While practice patterns vary, the procedures used in the trial reflect what is considered "usual and standard" practice. Second, because half of the patients with inducible sustained ventricular tachycardia will be given no antiarrhythmic therapy, we will be able to ascertain the true risk of sudden death in this patient population without the influence of these agents. Third, this trial will assess the usefulness of a method of guiding antiarrhythmic therapy (electrophysiologic testing) to reduce mortality in this high-risk population. It will not evaluate the efficacy of a specific type of antiarrhythmic therapy.

Original languageEnglish (US)
Pages (from-to)215-226
Number of pages12
JournalProgress in Cardiovascular Diseases
Volume36
Issue number3
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Buxton, A. E., Fisher, J. D., Josephson, M. E., Lee, K. L., Pryor, D. B., Prystowsky, E. N., Simson, M. B., DiCarlo, L., Echt, D. S., Packer, D., Stephen Greer, G., Talajic, M., & the MUSTT Investigators, MUSTT. I. (1993). Prevention of sudden death in patients with coronary artery disease: The multicenter unsustained tachycardia trial (MUSTT). Progress in Cardiovascular Diseases, 36(3), 215-226. https://doi.org/10.1016/0033-0620(93)90015-6