Prevention of glucocorticoid morbidity in giant cell arteritis

Frank Buttgereit, Eric Lawrence Matteson, Christian Dejaco, Bhaskar Dasgupta

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Glucocorticoids are the mainstay of treatment for GCA. Patients often require long-term treatment that may be associated with numerous adverse effects, depending on the dose and the duration of treatment. Trends in recent decades for glucocorticoid use in GCA suggest increasing cumulative doses and longer exposures. Common adverse events (AEs) reported in glucocorticoid-treated GCA patients include osteoporosis, hypercholesterolaemia, hypertension, posterior subcapsular cataract, infections, diabetes mellitus, Cushingoid appearance, adrenal insufficiency and aseptic necrosis of bone. AEs considered most worrisome by patients and rheumatologists include weight gain, psychological effects, osteoporosis, cardiometabolic complications and infections. The challenge is to maximize the benefit-risk ratio by giving the maximum glucocorticoid treatment necessary to control GCA initially and then to prevent relapse but to give the minimum treatment possible to avoid glucocorticoid-related AEs. We discuss the safety issues associated with long-term glucocorticoid use in patients with GCA and strategies for preventing glucocorticoid-related morbidity.

Original languageEnglish (US)
Pages (from-to)ii11-ii21
JournalRheumatology (United Kingdom)
Volume57
DOIs
StatePublished - Feb 1 2018
Externally publishedYes

Keywords

  • Adverse events
  • Giant cell arteritis
  • Glucocorticoids
  • Morbidity

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Prevention of glucocorticoid morbidity in giant cell arteritis'. Together they form a unique fingerprint.

  • Cite this