Prevention of colorectal cancer in inflammatory bowel disease: Value of screening and 5-aminosalicylates

Pia Munkholm, Edward Vincent Loftus, Jr, Anke Reinacher-Schick, Asher Kornbluth, Ulrich Mittmann, Burak Esendal

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Colorectal cancer is a serious complication of inflammatory bowel disease. Given this fact, it is necessary to examine the opportunities for current and future approaches to colorectal cancer prevention. The value of surveillance colonoscopy and chemoprevention of colorectal cancer with 5′- aminosalicylic acid has been evalu-ated in the recent literature. The current state of knowledge in the epidemiology of and new approaches to the prevention of cancer and dysplasia in inflammatory bowel disease were reviewed. It is concluded that there is significant preclinical and clinical evidence to suggest that 5-aminosalicylate drugs reduce the risk of colorectal neoplasia. However, the minimal dosage to achieve this chemopreventive effect remains unclear. There is also indirect evidence to suggest that surveillance colonoscopy is beneficial for patients with inflammatory bowel disease, particularly in those with long-standing pancolitis or primary sclerosing cholangitis-associated inflammatory bowel disease. However, definitive proof from prospective clinical trials is not available.

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalDigestion
Volume73
Issue number1
DOIs
StatePublished - Apr 2006

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Keywords

  • 5-Aminosalicylates
  • Colorectal cancer, prevention
  • Inflammatory bowel disease

ASJC Scopus subject areas

  • Gastroenterology

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