Prevention of collagen induced arthritis in mice by treatment with an antibody directed against the t cell receptor αbeta; framework

Kevin G. Moder, Harvinder S. Luthra, Ralph Kubo, Marie Griffiths, Chella S. David

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Collagen induced arthritis (CIA) is an animal model of inflammatory polyarthritis. Type II collagen is the major matrix protein of hyaline cartilage. Susceptibility to CIA is linked to the Major Histocompatibility Complex Class II genes but the presence of T cells expressing specific variable beta (Vβ) chain of their T cell receptor (TCR) is also required. Pretreatment with the monoclonal antibody H57-597 directed against the TCR αbeta; framework prevented the onset of arthritis in the majority of animals. The depletion of the T cell population did not lead to any apparent health problems. These experiments demonstrate the important role of the αbeta; T cell and its receptors in the CIA model. Further, anti-TCR αbeta; antibodies may be of value in the therapy of autoreactive disorders.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalAutoimmunity
Volume11
Issue number4
DOIs
StatePublished - 1992

Fingerprint

Experimental Arthritis
T-Cell Antigen Receptor
Antibodies
Arthritis
Hyaline Cartilage
T-Lymphocytes
MHC Class II Genes
Collagen Type II
Major Histocompatibility Complex
Animal Models
Monoclonal Antibodies
Health
Population
Proteins
Therapeutics

Keywords

  • Collagen induced arthritis
  • Immunotherapy
  • Monoclonal antibody
  • Rheumatoid arthritis
  • T cell receptor
  • αbeta; framework

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Prevention of collagen induced arthritis in mice by treatment with an antibody directed against the t cell receptor αbeta; framework. / Moder, Kevin G.; Luthra, Harvinder S.; Kubo, Ralph; Griffiths, Marie; David, Chella S.

In: Autoimmunity, Vol. 11, No. 4, 1992, p. 219-224.

Research output: Contribution to journalArticle

Moder, Kevin G. ; Luthra, Harvinder S. ; Kubo, Ralph ; Griffiths, Marie ; David, Chella S. / Prevention of collagen induced arthritis in mice by treatment with an antibody directed against the t cell receptor αbeta; framework. In: Autoimmunity. 1992 ; Vol. 11, No. 4. pp. 219-224.
@article{f6f4193c7519406f8760f1bf95eda896,
title = "Prevention of collagen induced arthritis in mice by treatment with an antibody directed against the t cell receptor αbeta; framework",
abstract = "Collagen induced arthritis (CIA) is an animal model of inflammatory polyarthritis. Type II collagen is the major matrix protein of hyaline cartilage. Susceptibility to CIA is linked to the Major Histocompatibility Complex Class II genes but the presence of T cells expressing specific variable beta (Vβ) chain of their T cell receptor (TCR) is also required. Pretreatment with the monoclonal antibody H57-597 directed against the TCR αbeta; framework prevented the onset of arthritis in the majority of animals. The depletion of the T cell population did not lead to any apparent health problems. These experiments demonstrate the important role of the αbeta; T cell and its receptors in the CIA model. Further, anti-TCR αbeta; antibodies may be of value in the therapy of autoreactive disorders.",
keywords = "Collagen induced arthritis, Immunotherapy, Monoclonal antibody, Rheumatoid arthritis, T cell receptor, αbeta; framework",
author = "Moder, {Kevin G.} and Luthra, {Harvinder S.} and Ralph Kubo and Marie Griffiths and David, {Chella S.}",
year = "1992",
doi = "10.3109/08916939209035158",
language = "English (US)",
volume = "11",
pages = "219--224",
journal = "Autoimmunity",
issn = "0891-6934",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Prevention of collagen induced arthritis in mice by treatment with an antibody directed against the t cell receptor αbeta; framework

AU - Moder, Kevin G.

AU - Luthra, Harvinder S.

AU - Kubo, Ralph

AU - Griffiths, Marie

AU - David, Chella S.

PY - 1992

Y1 - 1992

N2 - Collagen induced arthritis (CIA) is an animal model of inflammatory polyarthritis. Type II collagen is the major matrix protein of hyaline cartilage. Susceptibility to CIA is linked to the Major Histocompatibility Complex Class II genes but the presence of T cells expressing specific variable beta (Vβ) chain of their T cell receptor (TCR) is also required. Pretreatment with the monoclonal antibody H57-597 directed against the TCR αbeta; framework prevented the onset of arthritis in the majority of animals. The depletion of the T cell population did not lead to any apparent health problems. These experiments demonstrate the important role of the αbeta; T cell and its receptors in the CIA model. Further, anti-TCR αbeta; antibodies may be of value in the therapy of autoreactive disorders.

AB - Collagen induced arthritis (CIA) is an animal model of inflammatory polyarthritis. Type II collagen is the major matrix protein of hyaline cartilage. Susceptibility to CIA is linked to the Major Histocompatibility Complex Class II genes but the presence of T cells expressing specific variable beta (Vβ) chain of their T cell receptor (TCR) is also required. Pretreatment with the monoclonal antibody H57-597 directed against the TCR αbeta; framework prevented the onset of arthritis in the majority of animals. The depletion of the T cell population did not lead to any apparent health problems. These experiments demonstrate the important role of the αbeta; T cell and its receptors in the CIA model. Further, anti-TCR αbeta; antibodies may be of value in the therapy of autoreactive disorders.

KW - Collagen induced arthritis

KW - Immunotherapy

KW - Monoclonal antibody

KW - Rheumatoid arthritis

KW - T cell receptor

KW - αbeta; framework

UR - http://www.scopus.com/inward/record.url?scp=0026608474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026608474&partnerID=8YFLogxK

U2 - 10.3109/08916939209035158

DO - 10.3109/08916939209035158

M3 - Article

C2 - 1533796

AN - SCOPUS:0026608474

VL - 11

SP - 219

EP - 224

JO - Autoimmunity

JF - Autoimmunity

SN - 0891-6934

IS - 4

ER -