Prevention of acute respiratory distress syndrome

Sonal Rachmale, Guangxi Li, Ognjen Gajic

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are characterized by rapid-onset respiratory failure after a variety of direct and indirect insults to the parenchyma or vasculature of the lungs. Abundant research has led to improvements in supportive care, but mortality from ALI/ARDS remains substantial. Surprisingly, little research has been done on ALI/ARDS prevention and patients at risk are often studied late into the course of the illness, after admission to intensive care unit. Early detection of at-risk patients is crucial for implementing preventive and therapeutic strategies early in the course. The mechanisms of ALI/ARDS offer an array of possible targets for prevention. Epidemiologic studies suggest a protective role of early treatment of shock and infection, avoidance of tidal hyperventilation, and minimizing plasma transfusion from alloimmunized donors. While systemic steroid administration has a limited role, promising novel pharmacoprevention strategies include antiplatelet agents, systemic and inhaled anticoagulants, inhaled steroids, and systemic administration of antioxidants and HMG-CoA reductase inhibitors. Here, we review recent advances in prevention of ALI/ARDS.

Original languageEnglish (US)
Pages (from-to)300-304
Number of pages5
JournalClinical Pulmonary Medicine
Volume18
Issue number6
DOIs
StatePublished - Nov 1 2011

Keywords

  • Acute respiratory distress syndrome
  • acute lung injury
  • prevention

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'Prevention of acute respiratory distress syndrome'. Together they form a unique fingerprint.

  • Cite this