Prevalence, pathophysiology, and treatment of patients with asthma and gastroesophageal reflux disease

Jeffrey A. Alexander, Loren W. Hunt, Ashok M. Patel

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

About one third of the US adult population experiences symptoms of gastroesophageal reflux on a monthly basis. Asthma is present in about 5% of the same population. This article reviews and summarizes the literature in the following areas: (1) prevalence of gastroesophageal reflux disease (GERD) in asthmatic patients based on clinical symptoms, endoscopic esophagitis, and 24-hour ambulatory esophageal pH recordings; (2) proposed pathophysiologic mechanisms linking the 2 diseases; and (3) medical and surgical treatment trial results of antireflux therapy for asthmatic patients. Asthmatic patients appear to have an increased prevalence of GERD symptoms and 24-hour esophageal acid exposure. The clinical management of these patients remains controversial. Common management approaches to GERD in asthmatic patients include medical therapy with a proton pump inhibitor and/or antireflux surgery, which improve asthma symptoms in many patients but minimally affect pulmonary function.

Original languageEnglish (US)
Pages (from-to)1055-1063
Number of pages9
JournalMayo Clinic proceedings
Volume75
Issue number10
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Medicine(all)

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