Prevalence, pathophysiology, and treatment of patients with asthma and gastroesophageal reflux disease

Jeffrey A. Alexander, Loren W. Hunt, Ashok M. Patel

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

About one third of the US adult population experiences symptoms of gastroesophageal reflux on a monthly basis. Asthma is present in about 5% of the same population. This article reviews and summarizes the literature in the following areas: (1) prevalence of gastroesophageal reflux disease (GERD) in asthmatic patients based on clinical symptoms, endoscopic esophagitis, and 24-hour ambulatory esophageal pH recordings; (2) proposed pathophysiologic mechanisms linking the 2 diseases; and (3) medical and surgical treatment trial results of antireflux therapy for asthmatic patients. Asthmatic patients appear to have an increased prevalence of GERD symptoms and 24-hour esophageal acid exposure. The clinical management of these patients remains controversial. Common management approaches to GERD in asthmatic patients include medical therapy with a proton pump inhibitor and/or antireflux surgery, which improve asthma symptoms in many patients but minimally affect pulmonary function.

Original languageEnglish (US)
Pages (from-to)1055-1063
Number of pages9
JournalMayo Clinic Proceedings
Volume75
Issue number10
StatePublished - 2000

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Gastroesophageal Reflux
Asthma
Therapeutics
Esophageal pH Monitoring
Esophagitis
Proton Pump Inhibitors
Population
Lung
Acids

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prevalence, pathophysiology, and treatment of patients with asthma and gastroesophageal reflux disease. / Alexander, Jeffrey A.; Hunt, Loren W.; Patel, Ashok M.

In: Mayo Clinic Proceedings, Vol. 75, No. 10, 2000, p. 1055-1063.

Research output: Contribution to journalReview article

Alexander, Jeffrey A. ; Hunt, Loren W. ; Patel, Ashok M. / Prevalence, pathophysiology, and treatment of patients with asthma and gastroesophageal reflux disease. In: Mayo Clinic Proceedings. 2000 ; Vol. 75, No. 10. pp. 1055-1063.
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