Prevalence of potential risk factors for stroke assessed by transesophageal echocardiography and carotid ultrasonography: The SPARC study

Irene Meissner, Jack P. Whisnant, Buoy K. Khandheria, Peter C. Spittell, W. Michael O'Fallon, Roess D. Pascoe, Maurice E Sarano, James B. Seward, Jody L. Covalt, Jorean D. Sicks, David O. Wiebers

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283 Citations (Scopus)

Abstract

Objective: The SPARC (Stroke Prevention: Assessment of Risk in a Community) study was designed to identify risk factors for stroke and cardiovascular disease using transesophageal echocardiography and carotid ultrasonography. This protocol was undertaken to establish a cohort in which putative risk factors for stroke were identified so that subsequent follow-up could discern the roles these risk factors play in stroke incidence. Subjects and Methods: This was a prospective, population-based study. A randomly selected cohort comprised 1475 Olmsted County, Minnesota, residents aged 45 years or older, of whom 588 agreed to participate. Transesophageal echocardiography and carotid ultrasonography were used for evaluation of the subjects. Prevalences of various cardiovascular and cerebrovascular conditions were determined. Results: Transesophageal echocardiography was successfully completed in 581 subjects. The prevalence (±SE) of patent foramen ovale was 25.6% (±1.9%), and that of atrial septal aneurysm was 2.2% (±0.6%). The prevalence of aortic atherosclerosis increased with age and was most common in the descending aorta, particularly in subjects 75 to 84 years old. The prevalence of strands on native valve was 46.4% (±2.2%). Carotid ultrasonography data for 567 participants revealed minimal atherosclerotic disease. Most subjects had minimal or mild carotid occlusive disease. The prevalence of moderate (50%-79%) and severe (80%-99%) stenosis was 7.7% (±1.1%) and 0.3% (±0.2%), respectively. Conclusions: This prospective study defines the prevalence of multiple potential cardiovascular and cerebrovascular risk factors, providing population-based data for ongoing follow-up of the risk of stroke.

Original languageEnglish (US)
Pages (from-to)862-869
Number of pages8
JournalMayo Clinic Proceedings
Volume74
Issue number9
StatePublished - 1999

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Transesophageal Echocardiography
Ultrasonography
Stroke
Patent Foramen Ovale
Thoracic Aorta
Population
Aneurysm
Atherosclerosis
Pathologic Constriction
Cardiovascular Diseases
Prospective Studies
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Meissner, I., Whisnant, J. P., Khandheria, B. K., Spittell, P. C., Michael O'Fallon, W., Pascoe, R. D., ... Wiebers, D. O. (1999). Prevalence of potential risk factors for stroke assessed by transesophageal echocardiography and carotid ultrasonography: The SPARC study. Mayo Clinic Proceedings, 74(9), 862-869.

Prevalence of potential risk factors for stroke assessed by transesophageal echocardiography and carotid ultrasonography : The SPARC study. / Meissner, Irene; Whisnant, Jack P.; Khandheria, Buoy K.; Spittell, Peter C.; Michael O'Fallon, W.; Pascoe, Roess D.; Sarano, Maurice E; Seward, James B.; Covalt, Jody L.; Sicks, Jorean D.; Wiebers, David O.

In: Mayo Clinic Proceedings, Vol. 74, No. 9, 1999, p. 862-869.

Research output: Contribution to journalArticle

Meissner, I, Whisnant, JP, Khandheria, BK, Spittell, PC, Michael O'Fallon, W, Pascoe, RD, Sarano, ME, Seward, JB, Covalt, JL, Sicks, JD & Wiebers, DO 1999, 'Prevalence of potential risk factors for stroke assessed by transesophageal echocardiography and carotid ultrasonography: The SPARC study', Mayo Clinic Proceedings, vol. 74, no. 9, pp. 862-869.
Meissner, Irene ; Whisnant, Jack P. ; Khandheria, Buoy K. ; Spittell, Peter C. ; Michael O'Fallon, W. ; Pascoe, Roess D. ; Sarano, Maurice E ; Seward, James B. ; Covalt, Jody L. ; Sicks, Jorean D. ; Wiebers, David O. / Prevalence of potential risk factors for stroke assessed by transesophageal echocardiography and carotid ultrasonography : The SPARC study. In: Mayo Clinic Proceedings. 1999 ; Vol. 74, No. 9. pp. 862-869.
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abstract = "Objective: The SPARC (Stroke Prevention: Assessment of Risk in a Community) study was designed to identify risk factors for stroke and cardiovascular disease using transesophageal echocardiography and carotid ultrasonography. This protocol was undertaken to establish a cohort in which putative risk factors for stroke were identified so that subsequent follow-up could discern the roles these risk factors play in stroke incidence. Subjects and Methods: This was a prospective, population-based study. A randomly selected cohort comprised 1475 Olmsted County, Minnesota, residents aged 45 years or older, of whom 588 agreed to participate. Transesophageal echocardiography and carotid ultrasonography were used for evaluation of the subjects. Prevalences of various cardiovascular and cerebrovascular conditions were determined. Results: Transesophageal echocardiography was successfully completed in 581 subjects. The prevalence (±SE) of patent foramen ovale was 25.6{\%} (±1.9{\%}), and that of atrial septal aneurysm was 2.2{\%} (±0.6{\%}). The prevalence of aortic atherosclerosis increased with age and was most common in the descending aorta, particularly in subjects 75 to 84 years old. The prevalence of strands on native valve was 46.4{\%} (±2.2{\%}). Carotid ultrasonography data for 567 participants revealed minimal atherosclerotic disease. Most subjects had minimal or mild carotid occlusive disease. The prevalence of moderate (50{\%}-79{\%}) and severe (80{\%}-99{\%}) stenosis was 7.7{\%} (±1.1{\%}) and 0.3{\%} (±0.2{\%}), respectively. Conclusions: This prospective study defines the prevalence of multiple potential cardiovascular and cerebrovascular risk factors, providing population-based data for ongoing follow-up of the risk of stroke.",
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T2 - The SPARC study

AU - Meissner, Irene

AU - Whisnant, Jack P.

AU - Khandheria, Buoy K.

AU - Spittell, Peter C.

AU - Michael O'Fallon, W.

AU - Pascoe, Roess D.

AU - Sarano, Maurice E

AU - Seward, James B.

AU - Covalt, Jody L.

AU - Sicks, Jorean D.

AU - Wiebers, David O.

PY - 1999

Y1 - 1999

N2 - Objective: The SPARC (Stroke Prevention: Assessment of Risk in a Community) study was designed to identify risk factors for stroke and cardiovascular disease using transesophageal echocardiography and carotid ultrasonography. This protocol was undertaken to establish a cohort in which putative risk factors for stroke were identified so that subsequent follow-up could discern the roles these risk factors play in stroke incidence. Subjects and Methods: This was a prospective, population-based study. A randomly selected cohort comprised 1475 Olmsted County, Minnesota, residents aged 45 years or older, of whom 588 agreed to participate. Transesophageal echocardiography and carotid ultrasonography were used for evaluation of the subjects. Prevalences of various cardiovascular and cerebrovascular conditions were determined. Results: Transesophageal echocardiography was successfully completed in 581 subjects. The prevalence (±SE) of patent foramen ovale was 25.6% (±1.9%), and that of atrial septal aneurysm was 2.2% (±0.6%). The prevalence of aortic atherosclerosis increased with age and was most common in the descending aorta, particularly in subjects 75 to 84 years old. The prevalence of strands on native valve was 46.4% (±2.2%). Carotid ultrasonography data for 567 participants revealed minimal atherosclerotic disease. Most subjects had minimal or mild carotid occlusive disease. The prevalence of moderate (50%-79%) and severe (80%-99%) stenosis was 7.7% (±1.1%) and 0.3% (±0.2%), respectively. Conclusions: This prospective study defines the prevalence of multiple potential cardiovascular and cerebrovascular risk factors, providing population-based data for ongoing follow-up of the risk of stroke.

AB - Objective: The SPARC (Stroke Prevention: Assessment of Risk in a Community) study was designed to identify risk factors for stroke and cardiovascular disease using transesophageal echocardiography and carotid ultrasonography. This protocol was undertaken to establish a cohort in which putative risk factors for stroke were identified so that subsequent follow-up could discern the roles these risk factors play in stroke incidence. Subjects and Methods: This was a prospective, population-based study. A randomly selected cohort comprised 1475 Olmsted County, Minnesota, residents aged 45 years or older, of whom 588 agreed to participate. Transesophageal echocardiography and carotid ultrasonography were used for evaluation of the subjects. Prevalences of various cardiovascular and cerebrovascular conditions were determined. Results: Transesophageal echocardiography was successfully completed in 581 subjects. The prevalence (±SE) of patent foramen ovale was 25.6% (±1.9%), and that of atrial septal aneurysm was 2.2% (±0.6%). The prevalence of aortic atherosclerosis increased with age and was most common in the descending aorta, particularly in subjects 75 to 84 years old. The prevalence of strands on native valve was 46.4% (±2.2%). Carotid ultrasonography data for 567 participants revealed minimal atherosclerotic disease. Most subjects had minimal or mild carotid occlusive disease. The prevalence of moderate (50%-79%) and severe (80%-99%) stenosis was 7.7% (±1.1%) and 0.3% (±0.2%), respectively. Conclusions: This prospective study defines the prevalence of multiple potential cardiovascular and cerebrovascular risk factors, providing population-based data for ongoing follow-up of the risk of stroke.

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