Prevalence of Nephrolithiasis in Patients with Chronic Liver Disease: A Case-Control Study

Ivan Porter, William C. Palmer, Alexander Parker, David O. Hodge, Nancy N. Diehl, William E Haley

Research output: Contribution to journalArticle

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Abstract

Background and aims: Nephrolithiasis is known to be associated with several systemic diseases including chronic kidney disease and renal failure, which can also occur as a complication of chronic liver disease (CLD). This study aimed to assess the prevalence of nephrolithiasis in patients with CLD. Methods: A short survey was completed by 198 patients with CLD and 322 controls matched by age, sex, and state of residence. A primary diagnosis of liver disease was confirmed with health record review. Results: The median age of the liver disease group was 63 years and 128 (65%) were male; the median age of the control group was 63 and 199 (63%) were male. Body mass index was higher in the liver disease group (27.8 vs 26.7, P <. .01). The most common liver disease diagnosis was hepatitis C (60 [30%]) followed by alcoholic cirrhosis (42 [21.2%]). The self-reported prevalence of nephrolithiasis in the liver disease group was 26%, compared to 14% in the control group (P <. .01). This association remained significant after adjusting for age, sex, body mass index, and family history of kidney stones or liver disease. Conclusions: In this case-control, survey-based study, the prevalence of nephrolithiasis was 2 times higher in patients with CLD.

Original languageEnglish (US)
JournalJournal of Clinical and Experimental Hepatology
DOIs
StateAccepted/In press - Jan 1 2018

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Nephrolithiasis
Case-Control Studies
Liver Diseases
Chronic Disease
Chronic Kidney Failure
Body Mass Index
Alcoholic Liver Cirrhosis
Control Groups
Kidney Calculi
Kidney Diseases
Hepatitis C
Chronic Renal Insufficiency
Age Groups
Cross-Sectional Studies

Keywords

  • Hepatic failure
  • Steatohepatitis
  • Urolithiasis

ASJC Scopus subject areas

  • Hepatology

Cite this

Prevalence of Nephrolithiasis in Patients with Chronic Liver Disease : A Case-Control Study. / Porter, Ivan; Palmer, William C.; Parker, Alexander; Hodge, David O.; Diehl, Nancy N.; Haley, William E.

In: Journal of Clinical and Experimental Hepatology, 01.01.2018.

Research output: Contribution to journalArticle

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abstract = "Background and aims: Nephrolithiasis is known to be associated with several systemic diseases including chronic kidney disease and renal failure, which can also occur as a complication of chronic liver disease (CLD). This study aimed to assess the prevalence of nephrolithiasis in patients with CLD. Methods: A short survey was completed by 198 patients with CLD and 322 controls matched by age, sex, and state of residence. A primary diagnosis of liver disease was confirmed with health record review. Results: The median age of the liver disease group was 63 years and 128 (65{\%}) were male; the median age of the control group was 63 and 199 (63{\%}) were male. Body mass index was higher in the liver disease group (27.8 vs 26.7, P <. .01). The most common liver disease diagnosis was hepatitis C (60 [30{\%}]) followed by alcoholic cirrhosis (42 [21.2{\%}]). The self-reported prevalence of nephrolithiasis in the liver disease group was 26{\%}, compared to 14{\%} in the control group (P <. .01). This association remained significant after adjusting for age, sex, body mass index, and family history of kidney stones or liver disease. Conclusions: In this case-control, survey-based study, the prevalence of nephrolithiasis was 2 times higher in patients with CLD.",
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