Prevalence of monoclonal gammopathy of undetermined significance

Robert A. Kyle, Terry M Therneau, S Vincent Rajkumar, Dirk R. Larson, Matthew F. Plevak, Janice R. Offord, Angela Dispenzieri, Jerry A. Katzmann, L. Joseph Melton

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Abstract

BACKGROUND: The prevalence of monoclonal gammopathy of undetermined significance (MGUS), a premalignant plasma-cell disorder, among persons 50 years of age or older has not been accurately determined. We used sensitive laboratory techniques to ascertain the prevalence of MGUS in a large population in a well-defined geographic area. METHODS: We identified all living residents of Olmsted County, Minnesota, as of January 1, 1995. We obtained serum that remained after the performance of routine clinical tests at Mayo Clinic or asked subjects for whom such serum was unavailable to provide a sample. Agarose-gel electrophoresis was performed on all serum samples, and any serum sample with a discrete band of monoclonal protein or thought to have a localized band was subjected to immunofixation. RESULTS: Serum samples were obtained from 21,463 of the 28,038 enumerated residents 50 years of age or older (76.6 percent). MGUS was identified in 694 (3.2 percent) of these persons. Age-adjusted rates were higher in men than in women (4.0 percent vs. 2.7 percent, P<0.001). The prevalence of MGUS was 5.3 percent among persons 70 years of age or older and 7.5 percent among those 85 years of age or older. The concentration of monoclonal immunoglobulin was less than 1.0 g per deciliter in 63.5 percent and at least 2.0 g per deciliter in only 4.5 percent of 694 persons. The concentration of uninvolved immunoglobulins was reduced in 27.7 percent of 447 persons tested, and 21.5 percent of 79 tested had a monoclonal urinary light chain. CONCLUSIONS: Among residents of Olmsted County, Minnesota, MGUS was found in 3.2 percent of persons 50 years of age or older and 5.3 percent of persons 70 years of age or older.

Original languageEnglish (US)
Pages (from-to)1362-1369
Number of pages8
JournalNew England Journal of Medicine
Volume354
Issue number13
DOIs
StatePublished - Mar 30 2006

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Monoclonal Gammopathy of Undetermined Significance
Serum
Immunoglobulins
Agar Gel Electrophoresis
Plasma Cells
Light

ASJC Scopus subject areas

  • Medicine(all)

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Prevalence of monoclonal gammopathy of undetermined significance. / Kyle, Robert A.; Therneau, Terry M; Rajkumar, S Vincent; Larson, Dirk R.; Plevak, Matthew F.; Offord, Janice R.; Dispenzieri, Angela; Katzmann, Jerry A.; Melton, L. Joseph.

In: New England Journal of Medicine, Vol. 354, No. 13, 30.03.2006, p. 1362-1369.

Research output: Contribution to journalArticle

Kyle, RA, Therneau, TM, Rajkumar, SV, Larson, DR, Plevak, MF, Offord, JR, Dispenzieri, A, Katzmann, JA & Melton, LJ 2006, 'Prevalence of monoclonal gammopathy of undetermined significance', New England Journal of Medicine, vol. 354, no. 13, pp. 1362-1369. https://doi.org/10.1056/NEJMoa054494
Kyle, Robert A. ; Therneau, Terry M ; Rajkumar, S Vincent ; Larson, Dirk R. ; Plevak, Matthew F. ; Offord, Janice R. ; Dispenzieri, Angela ; Katzmann, Jerry A. ; Melton, L. Joseph. / Prevalence of monoclonal gammopathy of undetermined significance. In: New England Journal of Medicine. 2006 ; Vol. 354, No. 13. pp. 1362-1369.
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AU - Kyle, Robert A.

AU - Therneau, Terry M

AU - Rajkumar, S Vincent

AU - Larson, Dirk R.

AU - Plevak, Matthew F.

AU - Offord, Janice R.

AU - Dispenzieri, Angela

AU - Katzmann, Jerry A.

AU - Melton, L. Joseph

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N2 - BACKGROUND: The prevalence of monoclonal gammopathy of undetermined significance (MGUS), a premalignant plasma-cell disorder, among persons 50 years of age or older has not been accurately determined. We used sensitive laboratory techniques to ascertain the prevalence of MGUS in a large population in a well-defined geographic area. METHODS: We identified all living residents of Olmsted County, Minnesota, as of January 1, 1995. We obtained serum that remained after the performance of routine clinical tests at Mayo Clinic or asked subjects for whom such serum was unavailable to provide a sample. Agarose-gel electrophoresis was performed on all serum samples, and any serum sample with a discrete band of monoclonal protein or thought to have a localized band was subjected to immunofixation. RESULTS: Serum samples were obtained from 21,463 of the 28,038 enumerated residents 50 years of age or older (76.6 percent). MGUS was identified in 694 (3.2 percent) of these persons. Age-adjusted rates were higher in men than in women (4.0 percent vs. 2.7 percent, P<0.001). The prevalence of MGUS was 5.3 percent among persons 70 years of age or older and 7.5 percent among those 85 years of age or older. The concentration of monoclonal immunoglobulin was less than 1.0 g per deciliter in 63.5 percent and at least 2.0 g per deciliter in only 4.5 percent of 694 persons. The concentration of uninvolved immunoglobulins was reduced in 27.7 percent of 447 persons tested, and 21.5 percent of 79 tested had a monoclonal urinary light chain. CONCLUSIONS: Among residents of Olmsted County, Minnesota, MGUS was found in 3.2 percent of persons 50 years of age or older and 5.3 percent of persons 70 years of age or older.

AB - BACKGROUND: The prevalence of monoclonal gammopathy of undetermined significance (MGUS), a premalignant plasma-cell disorder, among persons 50 years of age or older has not been accurately determined. We used sensitive laboratory techniques to ascertain the prevalence of MGUS in a large population in a well-defined geographic area. METHODS: We identified all living residents of Olmsted County, Minnesota, as of January 1, 1995. We obtained serum that remained after the performance of routine clinical tests at Mayo Clinic or asked subjects for whom such serum was unavailable to provide a sample. Agarose-gel electrophoresis was performed on all serum samples, and any serum sample with a discrete band of monoclonal protein or thought to have a localized band was subjected to immunofixation. RESULTS: Serum samples were obtained from 21,463 of the 28,038 enumerated residents 50 years of age or older (76.6 percent). MGUS was identified in 694 (3.2 percent) of these persons. Age-adjusted rates were higher in men than in women (4.0 percent vs. 2.7 percent, P<0.001). The prevalence of MGUS was 5.3 percent among persons 70 years of age or older and 7.5 percent among those 85 years of age or older. The concentration of monoclonal immunoglobulin was less than 1.0 g per deciliter in 63.5 percent and at least 2.0 g per deciliter in only 4.5 percent of 694 persons. The concentration of uninvolved immunoglobulins was reduced in 27.7 percent of 447 persons tested, and 21.5 percent of 79 tested had a monoclonal urinary light chain. CONCLUSIONS: Among residents of Olmsted County, Minnesota, MGUS was found in 3.2 percent of persons 50 years of age or older and 5.3 percent of persons 70 years of age or older.

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