Prevalence of hepatitis c in patients with idiopathic glomerulopathies in native and transplant kidneys

Fernando G Cosio, Zeidy Roche, Anil Agarwal, Michael E. Falkenhain, Daniel D. Sedmak, Ronald M. Ferguson

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Previous studies suggest that there is an association between hepatitis C (HCV) infection and glomerular diseases in native and transplanted kidneys. However, the data are controversial. To reexamine this issue, we determined the prevalence of serum anti-HCV antibodies in patients with glomerulopathies of native kidneys (n = 105) end in patients with acute and chronic transplant glomerulopathy (TxGN) (n=62). Compared with a control group of patients with diabetic nephropathy (n = 37, 0% HCV +), the prevalence of HCV antibodies was significantly higher in patients with focal glomerulosclerosis (FGS) (4 of 32, 13%, P = 0.04 by chi-square), but not in patients with membranous nephropathy (MGN) (1 of 19, 5%) or in patients with membranoproliferative glomerulonephritis (MPGN) (2 of 17, 12%). All of the patients with positive HCV serology had histories of intravenous (IV) drug use. Thus, HCV serology was negative in all of the patients with native glomerulopathies without histories of IV drug use. Compared with a group of 105 transplant patients without TxGN (1.8% HCV+), the prevalence of HCV antibodies was significantly higher in patients with acute (A)TxGN (12 or 41: 29%. P=0.0004) and in patients with chronic (C)TxGN (9 of 27: 33%, P=0.0004). Compared with controls, patients with ATxGN also had a significantly higher prevalence of serum immunoglobulin (Ig) M antibodies to cytomegalovirus (CMV) (3% and 26% of patients, respectively, P = 0.0004}. However, there were no statistical associations between HCV and CMV serologies. These results do not support the postulate that HCV infection is associated with idiopathic native glomerulopathies; instead, the data suggest that the presence of HCV positivity in these patients can be explained by the inclusion of patients with a history of IV drug use. In contrast, these studies demonstrate for the first time an association between HCV infection and transplant glomerulopathies.

Original languageEnglish (US)
Pages (from-to)752-758
Number of pages7
JournalAmerican Journal of Kidney Diseases
Volume28
Issue number5
StatePublished - Nov 1996
Externally publishedYes

Fingerprint

Hepatitis
Transplants
Kidney
Hepatitis C Antibodies
Serology
Cytomegalovirus
Infection
Pharmaceutical Preparations
Membranoproliferative Glomerulonephritis
Focal Segmental Glomerulosclerosis
Membranous Glomerulonephritis
Diabetic Nephropathies
Hepatitis C
Serum
Immunoglobulin M

Keywords

  • glomerulonephritis
  • Hepatitis C
  • transplantation

ASJC Scopus subject areas

  • Nephrology

Cite this

Cosio, F. G., Roche, Z., Agarwal, A., Falkenhain, M. E., Sedmak, D. D., & Ferguson, R. M. (1996). Prevalence of hepatitis c in patients with idiopathic glomerulopathies in native and transplant kidneys. American Journal of Kidney Diseases, 28(5), 752-758.

Prevalence of hepatitis c in patients with idiopathic glomerulopathies in native and transplant kidneys. / Cosio, Fernando G; Roche, Zeidy; Agarwal, Anil; Falkenhain, Michael E.; Sedmak, Daniel D.; Ferguson, Ronald M.

In: American Journal of Kidney Diseases, Vol. 28, No. 5, 11.1996, p. 752-758.

Research output: Contribution to journalArticle

Cosio, FG, Roche, Z, Agarwal, A, Falkenhain, ME, Sedmak, DD & Ferguson, RM 1996, 'Prevalence of hepatitis c in patients with idiopathic glomerulopathies in native and transplant kidneys', American Journal of Kidney Diseases, vol. 28, no. 5, pp. 752-758.
Cosio FG, Roche Z, Agarwal A, Falkenhain ME, Sedmak DD, Ferguson RM. Prevalence of hepatitis c in patients with idiopathic glomerulopathies in native and transplant kidneys. American Journal of Kidney Diseases. 1996 Nov;28(5):752-758.
Cosio, Fernando G ; Roche, Zeidy ; Agarwal, Anil ; Falkenhain, Michael E. ; Sedmak, Daniel D. ; Ferguson, Ronald M. / Prevalence of hepatitis c in patients with idiopathic glomerulopathies in native and transplant kidneys. In: American Journal of Kidney Diseases. 1996 ; Vol. 28, No. 5. pp. 752-758.
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abstract = "Previous studies suggest that there is an association between hepatitis C (HCV) infection and glomerular diseases in native and transplanted kidneys. However, the data are controversial. To reexamine this issue, we determined the prevalence of serum anti-HCV antibodies in patients with glomerulopathies of native kidneys (n = 105) end in patients with acute and chronic transplant glomerulopathy (TxGN) (n=62). Compared with a control group of patients with diabetic nephropathy (n = 37, 0{\%} HCV +), the prevalence of HCV antibodies was significantly higher in patients with focal glomerulosclerosis (FGS) (4 of 32, 13{\%}, P = 0.04 by chi-square), but not in patients with membranous nephropathy (MGN) (1 of 19, 5{\%}) or in patients with membranoproliferative glomerulonephritis (MPGN) (2 of 17, 12{\%}). All of the patients with positive HCV serology had histories of intravenous (IV) drug use. Thus, HCV serology was negative in all of the patients with native glomerulopathies without histories of IV drug use. Compared with a group of 105 transplant patients without TxGN (1.8{\%} HCV+), the prevalence of HCV antibodies was significantly higher in patients with acute (A)TxGN (12 or 41: 29{\%}. P=0.0004) and in patients with chronic (C)TxGN (9 of 27: 33{\%}, P=0.0004). Compared with controls, patients with ATxGN also had a significantly higher prevalence of serum immunoglobulin (Ig) M antibodies to cytomegalovirus (CMV) (3{\%} and 26{\%} of patients, respectively, P = 0.0004}. However, there were no statistical associations between HCV and CMV serologies. These results do not support the postulate that HCV infection is associated with idiopathic native glomerulopathies; instead, the data suggest that the presence of HCV positivity in these patients can be explained by the inclusion of patients with a history of IV drug use. In contrast, these studies demonstrate for the first time an association between HCV infection and transplant glomerulopathies.",
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