Prevalence of erythrocyte haemoglobin H inclusions in unselected patients with clonal myeloid disorders

David P. Steensma, Julie C. Porcher, Curtis A. Hanson, Cynthia L. Lathrop, James D. Hoyer, Terra A. Lasho, Ayalew Tefferi, Douglas R. Higgs

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Patients with clonal myeloid disorders, especially myelodysplastic syndromes (MDS), may acquire α-thalassaemia. To estimate the prevalence of this erythrocyte phenotype, we examined brilliant cresyl blue-stained blood smears from 201 patients with neoplastic myeloid disorders and 282 controls (195 non-clonal anaemia, 62 with medical illnesses without anaemia and 25 healthy persons). Haemoglobin H inclusions were detected in 8/100 patients with MDS (8%) and 2/81 (2.5%) patients with myeloproliferative disorders, but in none of the acute leukaemia patients or controls. We conclude that the emergence of thalassaemic clones may be relatively common in the disordered marrow milieu of MDS.

Original languageEnglish (US)
Pages (from-to)439-442
Number of pages4
JournalBritish journal of haematology
Volume139
Issue number3
DOIs
StatePublished - Nov 2007

Keywords

  • ATRX
  • Clonal evolution
  • Haemoglobin H
  • Myelodysplastic syndromes
  • Myeloproliferative disorders

ASJC Scopus subject areas

  • Hematology

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