Prevalence of cerebral cavernous malformations associated with developmental venous anomalies increases with age

Waleed Brinjikji, Ali El Rida El-Masri, John T. Wald, Kelly Flemming, Giuseppe Lanzino

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Background and purpose: To test the hypothesis that the prevalence of cerebral cavernous malformation (CCM) associated with developmental venous anomalies (DVAs) increases with age, we studied the age-related prevalence of DVA-associated CCM among patients with DVAs. Materials and methods: Patients with DVAs on contrast-enhanced MRI exams performed over a 2-year period were included in this study. A single neuroradiologist reviewed all imaging exams for the presence of CCMs. Baseline demographic data collected included age, gender, presence of CNS neoplasm, history of cranial radiation, and history of seizure. Patients were divided into age groups based on decade of life. Cochran-Armitage trend tests were performed to determine if increasing age was associated with CCM prevalence. Results: A total of 1689 patients with DVAs identified on contrast-enhanced MRI were included. Of these patients, 116 (6.9%) had a cavernous malformation associated with the DVA. There was a significant positive association between age and the prevalence of DVA-associated CCM (P = 0.002). The prevalence of DVA-associated CCM was 0.8% for the 0–10 age group, 1.6% for the 11–20 age group, 7.5% for the 21–30 age group, 9.5% for the 31–40 age group, 6.1% for the 41–50 age group, 6.3% for the 51–60 age group, 7.4% for the 61–70 age group, and 11.6% for the >70 age group (P < .0001). Conclusions: Our study demonstrated an age-related increase in prevalence of DVA-associated cavernous malformations among patients with DVAs. These findings suggest that DVA-associated cavernous malformations are acquired lesions.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalChild's Nervous System
StateAccepted/In press - Jun 22 2017


  • Cavernous malformation
  • De novo
  • Developmental venous anomaly
  • Natural history
  • Vascular malformation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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