Prevalence of adverse effects in corticosteroid dependent asthmatics.

R. Fitzsimons, L. C. Grammer, J. M. Halwig, Timothy Aksamit, R. Patterson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Eighty-five corticosteroid dependent patients with respiratory diseases requiring alternate day prednisone were studied for certain adverse effects that have been reported to be associated with corticosteroid therapy. The mean age of the patients was 52 years, the average years of prednisone therapy was 5.3, and the mean dose of alternate day prednisone was 26.2 mg. In this group of 85 patients the prevalence of hypertension, peptic ulcer disease, pathologic fractures and psychosis was not statistically increased over that of the general population. None of the patients was diagnosed as having steroid-induced psychosis, pancreatitis or tuberculosis. One patient developed aseptic necrosis of the hip; however, she received daily prednisone for approximately 3.2 years before being converted to an alternate day schedule. Our results demonstrate that alternate day corticosteroid therapy can be used without significant risk of adverse effects in patients in whom it is essential for control of respiratory disease.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalNew England and regional allergy proceedings
Volume9
Issue number2
StatePublished - Mar 1988
Externally publishedYes

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Adrenal Cortex Hormones
Prednisone
Psychotic Disorders
Spontaneous Fractures
Peptic Ulcer
Pancreatitis
Hip
Appointments and Schedules
Tuberculosis
Necrosis
Therapeutics
Steroids
Hypertension
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fitzsimons, R., Grammer, L. C., Halwig, J. M., Aksamit, T., & Patterson, R. (1988). Prevalence of adverse effects in corticosteroid dependent asthmatics. New England and regional allergy proceedings, 9(2), 157-162.

Prevalence of adverse effects in corticosteroid dependent asthmatics. / Fitzsimons, R.; Grammer, L. C.; Halwig, J. M.; Aksamit, Timothy; Patterson, R.

In: New England and regional allergy proceedings, Vol. 9, No. 2, 03.1988, p. 157-162.

Research output: Contribution to journalArticle

Fitzsimons, R, Grammer, LC, Halwig, JM, Aksamit, T & Patterson, R 1988, 'Prevalence of adverse effects in corticosteroid dependent asthmatics.', New England and regional allergy proceedings, vol. 9, no. 2, pp. 157-162.
Fitzsimons, R. ; Grammer, L. C. ; Halwig, J. M. ; Aksamit, Timothy ; Patterson, R. / Prevalence of adverse effects in corticosteroid dependent asthmatics. In: New England and regional allergy proceedings. 1988 ; Vol. 9, No. 2. pp. 157-162.
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