Prevalence of abnormal liver function tests in celiac disease and the effect of a gluten-free diet in the US Population

Natalia E. Castillo, Rohini R. Vanga, Thimmaiah G. Theethira, Alberto Rubio-Tapia, Joseph A Murray, Javier Villafuerte, Alan Bonder, Rupa Mukherjee, Joshua Hansen, Melinda Dennis, Ciaran P. Kelly, Daniel A. Leffler

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

OBJECTIVES: Guidelines recommend routine screening of liver function tests (LFTs) in patients diagnosed with celiac disease (CD). However, little is known about the prevalence of liver disorders in CD outside of Europe. Our aims were to estimate the prevalence of LFT abnormalities in CD and to evaluate the effect of a gluten-free diet (GFD) on LFTs. METHODS: Adult patients with biopsy-proven CD were identified from a prospectively maintained database and matched with healthy controls. LFT levels for women and men were defined as abnormal based on the Third National Health and Nutrition Examination Survey (NHANES III) criteria. Data on demographics, coexisting liver diseases, and laboratory work-ups including aspartate transaminase (AST) and alanine transaminase (ALT) values at the time of diagnosis and on a GFD were recorded. Subsequently, data from this cohort were compared with data from 7,789 individuals participating in the National Health and Nutrition Examination Survey, 2009-2010. Univariate logistic regression, Wilcoxon signed-ranks, Student's t-test, χ 2, and Fischer's exact test were used for statistical analysis. RESULTS: In 463 CD patients with ALT or AST levels at the time of CD diagnosis, 40.6% had elevated LFTs compared with 24.2% of treated CD patients (P

Original languageEnglish (US)
Pages (from-to)1216-1222
Number of pages7
JournalAmerican Journal of Gastroenterology
Volume110
Issue number8
DOIs
StatePublished - Aug 13 2015

ASJC Scopus subject areas

  • Gastroenterology

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    Castillo, N. E., Vanga, R. R., Theethira, T. G., Rubio-Tapia, A., Murray, J. A., Villafuerte, J., Bonder, A., Mukherjee, R., Hansen, J., Dennis, M., Kelly, C. P., & Leffler, D. A. (2015). Prevalence of abnormal liver function tests in celiac disease and the effect of a gluten-free diet in the US Population. American Journal of Gastroenterology, 110(8), 1216-1222. https://doi.org/10.1038/ajg.2015.192