Prevalence and spectrum of T-cell lymphoproliferative disorders in patients with Hypereosinophilia: A reference laboratory experience

Min Shi, Karen L. Rech, Gregory E. Otteson, Pedro Horna, Horatiu Olteanu, Animesh Pardanani, Dong Chen, Dragan Jevremovic

Research output: Contribution to journalReview article

Abstract

Hypereosinophilia (HE) is defined as persistently elevated absolute eosinophil count (AEC) ≥ 1.5 × 109/L, which can be due to a variety of underlying causes. In this study, we investigated the prevalence and spectrum of T-cell lymphoproliferative disorders in 124 consecutive patients with HE by flow cytometric immunophenotyping. Available medical records, pathology reports and T-cell receptor (TCR) gene rearrangement were reviewed. Fifteen patients (12%) with HE had abnormal T-cell populations that were initially detected by flow cytometry. The presence of immunophenotypically abnormal T cells was not associated with higher AEC or higher absolute lymphocyte count levels, in comparison to those without abnormal T cells. Molecular studies concordantly identified a clonal TCR gene rearrangement in 8 of 10 cases tested. Based on the combination of clinical presentation, morphologic findings and laboratory studies, seven patients were diagnosed with the lymphocytic variant of hypereosinophilic syndrome and five with overt T-cell lymphoma (4 peripheral T-cell lymphoma NOS, 1 primary cutaneous T-cell lymphoma). The remaining three had an unknown diagnosis due to lack of information and additional workup would be warranted. These findings underscore the importance of flow cytometry as a screening tool to identify T-cell lymphoproliferative disorders in patients with HE.

Original languageEnglish (US)
Article number151412
JournalAnnals of Diagnostic Pathology
Volume44
DOIs
StatePublished - Feb 2020

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Lymphoproliferative Disorders
T-Lymphocytes
T-Lymphocyte Gene Rearrangement
T-Cell Receptor Genes
Eosinophils
Flow Cytometry
Peripheral T-Cell Lymphoma
Hypereosinophilic Syndrome
Cutaneous T-Cell Lymphoma
Immunophenotyping
T-Cell Lymphoma
Lymphocyte Count
Medical Records
Pathology
Population

Keywords

  • Flow cytometry
  • Hypereosinophilia
  • T-cell lymphoproliferative disorder

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Prevalence and spectrum of T-cell lymphoproliferative disorders in patients with Hypereosinophilia : A reference laboratory experience. / Shi, Min; Rech, Karen L.; Otteson, Gregory E.; Horna, Pedro; Olteanu, Horatiu; Pardanani, Animesh; Chen, Dong; Jevremovic, Dragan.

In: Annals of Diagnostic Pathology, Vol. 44, 151412, 02.2020.

Research output: Contribution to journalReview article

Shi, Min ; Rech, Karen L. ; Otteson, Gregory E. ; Horna, Pedro ; Olteanu, Horatiu ; Pardanani, Animesh ; Chen, Dong ; Jevremovic, Dragan. / Prevalence and spectrum of T-cell lymphoproliferative disorders in patients with Hypereosinophilia : A reference laboratory experience. In: Annals of Diagnostic Pathology. 2020 ; Vol. 44.
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