Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children: A cohort study

Riten Kumar, Vilmarie Rodriguez, Jane M S Matsumoto, Shakila P. Khan, Amy L. Weaver, Robert D. McBane, Timothy J. Beebe, John A. Heit

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: While post thrombotic syndrome (PTS) is increasingly recognized as a frequent and potentially serious complication of deep vein thrombosis (DVT) in children, limited information is available regarding predictors of PTS. Methods: Using the Mayo Clinic Master Diagnostic Index, all pediatric patients (age 0 to 18 years) with a potential DVT based on ICD-8 codes over the 15-year period, 1995 to 2009 were identified. A validated PTS survey instrument was mailed to eligible patients followed by a second mailing and three reminder phone calls for non-responders. Baseline clinical and radiographic characteristics were abstracted from patient medical records and tested as potential predictors of PTS using logistic regression. Associations were summarized by calculating odds ratios (OR) and corresponding 95% confidence intervals. Results: Ninety patients agreed to participate. The mean age (±SD) at DVT diagnosis and survey completion were 12.8 (±6.1) and 19.3 (±7.7) years, respectively. Fifty three respondents (59%) reported mild PTS whereas 12 (13%) reported moderate-to-severe PTS. Pain (34%) and dilated blood vessels (40%) were the most frequent PTS symptom and sign, respectively. On multivariate analysis, predictors of PTS included duration between incident DVT and survey completion (OR 1.75; 95% CI: 1.08 - 2.84) and number of thrombosed vein segments (OR 1.40; 95% CI: 1.05 - 1.86). Conclusion: Over 70% of children with DVT report subsequent symptoms or signs of PTS, though only 13% report clinically significant, moderate-to-severe PTS. Number of thrombosed vein segments at diagnosis and time duration between incident DVT and survey completion were independent predictors of PTS.

Original languageEnglish (US)
Pages (from-to)347-351
Number of pages5
JournalThrombosis Research
Volume135
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Venous Thrombosis
Cohort Studies
Odds Ratio
Signs and Symptoms
Veins
Thrombosis
International Classification of Diseases
Medical Records
Blood Vessels
Multivariate Analysis
Logistic Models
Surveys and Questionnaires
Confidence Intervals
Pediatrics
Pain

Keywords

  • Deep vein thrombosis
  • Post thrombotic syndrome

ASJC Scopus subject areas

  • Hematology

Cite this

Kumar, R., Rodriguez, V., Matsumoto, J. M. S., Khan, S. P., Weaver, A. L., McBane, R. D., ... Heit, J. A. (2015). Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children: A cohort study. Thrombosis Research, 135(2), 347-351. https://doi.org/10.1016/j.thromres.2014.12.005

Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children : A cohort study. / Kumar, Riten; Rodriguez, Vilmarie; Matsumoto, Jane M S; Khan, Shakila P.; Weaver, Amy L.; McBane, Robert D.; Beebe, Timothy J.; Heit, John A.

In: Thrombosis Research, Vol. 135, No. 2, 01.02.2015, p. 347-351.

Research output: Contribution to journalArticle

Kumar, R, Rodriguez, V, Matsumoto, JMS, Khan, SP, Weaver, AL, McBane, RD, Beebe, TJ & Heit, JA 2015, 'Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children: A cohort study', Thrombosis Research, vol. 135, no. 2, pp. 347-351. https://doi.org/10.1016/j.thromres.2014.12.005
Kumar, Riten ; Rodriguez, Vilmarie ; Matsumoto, Jane M S ; Khan, Shakila P. ; Weaver, Amy L. ; McBane, Robert D. ; Beebe, Timothy J. ; Heit, John A. / Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children : A cohort study. In: Thrombosis Research. 2015 ; Vol. 135, No. 2. pp. 347-351.
@article{ea6e5b67c2174317bc72df2f8863e344,
title = "Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children: A cohort study",
abstract = "Background: While post thrombotic syndrome (PTS) is increasingly recognized as a frequent and potentially serious complication of deep vein thrombosis (DVT) in children, limited information is available regarding predictors of PTS. Methods: Using the Mayo Clinic Master Diagnostic Index, all pediatric patients (age 0 to 18 years) with a potential DVT based on ICD-8 codes over the 15-year period, 1995 to 2009 were identified. A validated PTS survey instrument was mailed to eligible patients followed by a second mailing and three reminder phone calls for non-responders. Baseline clinical and radiographic characteristics were abstracted from patient medical records and tested as potential predictors of PTS using logistic regression. Associations were summarized by calculating odds ratios (OR) and corresponding 95{\%} confidence intervals. Results: Ninety patients agreed to participate. The mean age (±SD) at DVT diagnosis and survey completion were 12.8 (±6.1) and 19.3 (±7.7) years, respectively. Fifty three respondents (59{\%}) reported mild PTS whereas 12 (13{\%}) reported moderate-to-severe PTS. Pain (34{\%}) and dilated blood vessels (40{\%}) were the most frequent PTS symptom and sign, respectively. On multivariate analysis, predictors of PTS included duration between incident DVT and survey completion (OR 1.75; 95{\%} CI: 1.08 - 2.84) and number of thrombosed vein segments (OR 1.40; 95{\%} CI: 1.05 - 1.86). Conclusion: Over 70{\%} of children with DVT report subsequent symptoms or signs of PTS, though only 13{\%} report clinically significant, moderate-to-severe PTS. Number of thrombosed vein segments at diagnosis and time duration between incident DVT and survey completion were independent predictors of PTS.",
keywords = "Deep vein thrombosis, Post thrombotic syndrome",
author = "Riten Kumar and Vilmarie Rodriguez and Matsumoto, {Jane M S} and Khan, {Shakila P.} and Weaver, {Amy L.} and McBane, {Robert D.} and Beebe, {Timothy J.} and Heit, {John A.}",
year = "2015",
month = "2",
day = "1",
doi = "10.1016/j.thromres.2014.12.005",
language = "English (US)",
volume = "135",
pages = "347--351",
journal = "Thrombosis Research",
issn = "0049-3848",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children

T2 - A cohort study

AU - Kumar, Riten

AU - Rodriguez, Vilmarie

AU - Matsumoto, Jane M S

AU - Khan, Shakila P.

AU - Weaver, Amy L.

AU - McBane, Robert D.

AU - Beebe, Timothy J.

AU - Heit, John A.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Background: While post thrombotic syndrome (PTS) is increasingly recognized as a frequent and potentially serious complication of deep vein thrombosis (DVT) in children, limited information is available regarding predictors of PTS. Methods: Using the Mayo Clinic Master Diagnostic Index, all pediatric patients (age 0 to 18 years) with a potential DVT based on ICD-8 codes over the 15-year period, 1995 to 2009 were identified. A validated PTS survey instrument was mailed to eligible patients followed by a second mailing and three reminder phone calls for non-responders. Baseline clinical and radiographic characteristics were abstracted from patient medical records and tested as potential predictors of PTS using logistic regression. Associations were summarized by calculating odds ratios (OR) and corresponding 95% confidence intervals. Results: Ninety patients agreed to participate. The mean age (±SD) at DVT diagnosis and survey completion were 12.8 (±6.1) and 19.3 (±7.7) years, respectively. Fifty three respondents (59%) reported mild PTS whereas 12 (13%) reported moderate-to-severe PTS. Pain (34%) and dilated blood vessels (40%) were the most frequent PTS symptom and sign, respectively. On multivariate analysis, predictors of PTS included duration between incident DVT and survey completion (OR 1.75; 95% CI: 1.08 - 2.84) and number of thrombosed vein segments (OR 1.40; 95% CI: 1.05 - 1.86). Conclusion: Over 70% of children with DVT report subsequent symptoms or signs of PTS, though only 13% report clinically significant, moderate-to-severe PTS. Number of thrombosed vein segments at diagnosis and time duration between incident DVT and survey completion were independent predictors of PTS.

AB - Background: While post thrombotic syndrome (PTS) is increasingly recognized as a frequent and potentially serious complication of deep vein thrombosis (DVT) in children, limited information is available regarding predictors of PTS. Methods: Using the Mayo Clinic Master Diagnostic Index, all pediatric patients (age 0 to 18 years) with a potential DVT based on ICD-8 codes over the 15-year period, 1995 to 2009 were identified. A validated PTS survey instrument was mailed to eligible patients followed by a second mailing and three reminder phone calls for non-responders. Baseline clinical and radiographic characteristics were abstracted from patient medical records and tested as potential predictors of PTS using logistic regression. Associations were summarized by calculating odds ratios (OR) and corresponding 95% confidence intervals. Results: Ninety patients agreed to participate. The mean age (±SD) at DVT diagnosis and survey completion were 12.8 (±6.1) and 19.3 (±7.7) years, respectively. Fifty three respondents (59%) reported mild PTS whereas 12 (13%) reported moderate-to-severe PTS. Pain (34%) and dilated blood vessels (40%) were the most frequent PTS symptom and sign, respectively. On multivariate analysis, predictors of PTS included duration between incident DVT and survey completion (OR 1.75; 95% CI: 1.08 - 2.84) and number of thrombosed vein segments (OR 1.40; 95% CI: 1.05 - 1.86). Conclusion: Over 70% of children with DVT report subsequent symptoms or signs of PTS, though only 13% report clinically significant, moderate-to-severe PTS. Number of thrombosed vein segments at diagnosis and time duration between incident DVT and survey completion were independent predictors of PTS.

KW - Deep vein thrombosis

KW - Post thrombotic syndrome

UR - http://www.scopus.com/inward/record.url?scp=84921547268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921547268&partnerID=8YFLogxK

U2 - 10.1016/j.thromres.2014.12.005

DO - 10.1016/j.thromres.2014.12.005

M3 - Article

C2 - 25528070

AN - SCOPUS:84921547268

VL - 135

SP - 347

EP - 351

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

IS - 2

ER -