Prevalence and outcome of thrombotic and embolic complications in adults after Fontan operation

Alexander Egbe, Heidi M. Connolly, Talha Niaz, Vidhushei Yogeswaran, Nathaniel W. Taggart, Muhammad Yasir Qureshi, Joseph T. Poterucha, Arooj Razzaq Khan, David J. Driscoll

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20 Scopus citations

Abstract

There are limited studies of thrombotic and embolic complications (TEC) in the adult Fontan population. The purpose of the study was to determine the prevalence, risk factors, and outcomes of TECs in this population. Methods Retrospective review of adults with a previous Fontan operation, with follow-up at Mayo Clinic, 1994-2014. Systemic TEC was defined as intracardiac thrombus, ischemic stroke, or systemic arterial embolus. Nonsystemic TEC was defined as Fontan conduit/right atrial thrombus or pulmonary embolus. Results We identified 387 patients with a mean (SD) age of 28 (7) years and a mean follow-up of 8 (2) years. An atriopulmonary connection (APC) was done for 286 patients (74%). Atrial arrhythmias were present in 278 (72%). There were 121 TECs (systemic n = 36, nonsystemic n = 85) in 98 patients (25%). Risk factors for systemic TEC were atrial arrhythmia (hazard ratio 2.28, P = .001) and APC (hazard ratio 1.98, P = .02); nonsystemic TEC also had similar risk factors. All 98 patients received warfarin. Warfarin was discontinued in 10 of 98 because of bleeding, and 8 of these 10 subsequently had a second TEC. Among the 82 patients who had follow-up imaging, 16 (20%) had resolution of thrombus. In total, 24 of 98 patients had a second TEC, most of whom had inadequate anticoagulation. Conclusions Thrombotic and embolic complication was not uncommon; risk factors for TEC were APC and atrial arrhythmias. Most patients were treated successfully with warfarin alone. A second TEC occurred in most patients whose anticoagulation was discontinued because of bleeding events.

Original languageEnglish (US)
Pages (from-to)10-17
Number of pages8
JournalAmerican Heart Journal
Volume183
DOIs
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Egbe, A., Connolly, H. M., Niaz, T., Yogeswaran, V., Taggart, N. W., Qureshi, M. Y., Poterucha, J. T., Khan, A. R., & Driscoll, D. J. (2017). Prevalence and outcome of thrombotic and embolic complications in adults after Fontan operation. American Heart Journal, 183, 10-17. https://doi.org/10.1016/j.ahj.2016.09.014