Prevalence and clinical outcomes of patients with multiple potential causes of syncope

Lin Y. Chen, Bernard J. Gersh, David O. Hodge, Wouter Wieling, Stephen C. Hammill, Win Kuang Shen

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Objective: To determine the prevalence, predictors, and prognosis of patients with multiple potential causes of syncope. Patients and Methods: This is a retrospective cohort study with prospective follow-up of consecutive patients with syncope of uncertain cause who were referred to the electrophysiology service for syncope evaluation from January 1, 1996, through December 31, 1998. The main outcome measures were prevalence of multiple potential causes of syncope, survival of patients with multiple potential causes of syncope compared with survival of patients with a single cause, and clinical predictors of multiple potential causes of syncope. Results: A total of 987 patients were studied (mean ± SD age, 58.0±21.4 years; male, 550 [55.7%]). Multiple potential causes were present in 182 patients (18.4%). Patients with multiple potential causes of syncope had a lower survival rate at 4 years, 73.1% (95% confidence interval, 64.6%-82.8%), vs those with a single cause, 89.3% (95% confidence interval, 86.4%-92.2%) (P<.001). Multivariate predictors of multiple potential causes were older age, atrial fibrillation, use of cardiac medications, and New York Heart Association classification II, III, and IV. Conclusion: Of the patients evaluated for syncope, 18.4% had multiple potential causes. The presence of multiple potential causes was an independent predictor of increased mortality among patients with syncope.

Original languageEnglish (US)
Pages (from-to)414-420
Number of pages7
JournalMayo Clinic Proceedings
Volume78
Issue number4
StatePublished - Apr 1 2003

Fingerprint

Syncope
Confidence Intervals
Survival
Electrophysiology
Atrial Fibrillation
Cohort Studies
Survival Rate
Retrospective Studies
Outcome Assessment (Health Care)
Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chen, L. Y., Gersh, B. J., Hodge, D. O., Wieling, W., Hammill, S. C., & Shen, W. K. (2003). Prevalence and clinical outcomes of patients with multiple potential causes of syncope. Mayo Clinic Proceedings, 78(4), 414-420.

Prevalence and clinical outcomes of patients with multiple potential causes of syncope. / Chen, Lin Y.; Gersh, Bernard J.; Hodge, David O.; Wieling, Wouter; Hammill, Stephen C.; Shen, Win Kuang.

In: Mayo Clinic Proceedings, Vol. 78, No. 4, 01.04.2003, p. 414-420.

Research output: Contribution to journalArticle

Chen, LY, Gersh, BJ, Hodge, DO, Wieling, W, Hammill, SC & Shen, WK 2003, 'Prevalence and clinical outcomes of patients with multiple potential causes of syncope', Mayo Clinic Proceedings, vol. 78, no. 4, pp. 414-420.
Chen LY, Gersh BJ, Hodge DO, Wieling W, Hammill SC, Shen WK. Prevalence and clinical outcomes of patients with multiple potential causes of syncope. Mayo Clinic Proceedings. 2003 Apr 1;78(4):414-420.
Chen, Lin Y. ; Gersh, Bernard J. ; Hodge, David O. ; Wieling, Wouter ; Hammill, Stephen C. ; Shen, Win Kuang. / Prevalence and clinical outcomes of patients with multiple potential causes of syncope. In: Mayo Clinic Proceedings. 2003 ; Vol. 78, No. 4. pp. 414-420.
@article{40ffb6595cdc42f895359225337fb91b,
title = "Prevalence and clinical outcomes of patients with multiple potential causes of syncope",
abstract = "Objective: To determine the prevalence, predictors, and prognosis of patients with multiple potential causes of syncope. Patients and Methods: This is a retrospective cohort study with prospective follow-up of consecutive patients with syncope of uncertain cause who were referred to the electrophysiology service for syncope evaluation from January 1, 1996, through December 31, 1998. The main outcome measures were prevalence of multiple potential causes of syncope, survival of patients with multiple potential causes of syncope compared with survival of patients with a single cause, and clinical predictors of multiple potential causes of syncope. Results: A total of 987 patients were studied (mean ± SD age, 58.0±21.4 years; male, 550 [55.7{\%}]). Multiple potential causes were present in 182 patients (18.4{\%}). Patients with multiple potential causes of syncope had a lower survival rate at 4 years, 73.1{\%} (95{\%} confidence interval, 64.6{\%}-82.8{\%}), vs those with a single cause, 89.3{\%} (95{\%} confidence interval, 86.4{\%}-92.2{\%}) (P<.001). Multivariate predictors of multiple potential causes were older age, atrial fibrillation, use of cardiac medications, and New York Heart Association classification II, III, and IV. Conclusion: Of the patients evaluated for syncope, 18.4{\%} had multiple potential causes. The presence of multiple potential causes was an independent predictor of increased mortality among patients with syncope.",
author = "Chen, {Lin Y.} and Gersh, {Bernard J.} and Hodge, {David O.} and Wouter Wieling and Hammill, {Stephen C.} and Shen, {Win Kuang}",
year = "2003",
month = "4",
day = "1",
language = "English (US)",
volume = "78",
pages = "414--420",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "4",

}

TY - JOUR

T1 - Prevalence and clinical outcomes of patients with multiple potential causes of syncope

AU - Chen, Lin Y.

AU - Gersh, Bernard J.

AU - Hodge, David O.

AU - Wieling, Wouter

AU - Hammill, Stephen C.

AU - Shen, Win Kuang

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Objective: To determine the prevalence, predictors, and prognosis of patients with multiple potential causes of syncope. Patients and Methods: This is a retrospective cohort study with prospective follow-up of consecutive patients with syncope of uncertain cause who were referred to the electrophysiology service for syncope evaluation from January 1, 1996, through December 31, 1998. The main outcome measures were prevalence of multiple potential causes of syncope, survival of patients with multiple potential causes of syncope compared with survival of patients with a single cause, and clinical predictors of multiple potential causes of syncope. Results: A total of 987 patients were studied (mean ± SD age, 58.0±21.4 years; male, 550 [55.7%]). Multiple potential causes were present in 182 patients (18.4%). Patients with multiple potential causes of syncope had a lower survival rate at 4 years, 73.1% (95% confidence interval, 64.6%-82.8%), vs those with a single cause, 89.3% (95% confidence interval, 86.4%-92.2%) (P<.001). Multivariate predictors of multiple potential causes were older age, atrial fibrillation, use of cardiac medications, and New York Heart Association classification II, III, and IV. Conclusion: Of the patients evaluated for syncope, 18.4% had multiple potential causes. The presence of multiple potential causes was an independent predictor of increased mortality among patients with syncope.

AB - Objective: To determine the prevalence, predictors, and prognosis of patients with multiple potential causes of syncope. Patients and Methods: This is a retrospective cohort study with prospective follow-up of consecutive patients with syncope of uncertain cause who were referred to the electrophysiology service for syncope evaluation from January 1, 1996, through December 31, 1998. The main outcome measures were prevalence of multiple potential causes of syncope, survival of patients with multiple potential causes of syncope compared with survival of patients with a single cause, and clinical predictors of multiple potential causes of syncope. Results: A total of 987 patients were studied (mean ± SD age, 58.0±21.4 years; male, 550 [55.7%]). Multiple potential causes were present in 182 patients (18.4%). Patients with multiple potential causes of syncope had a lower survival rate at 4 years, 73.1% (95% confidence interval, 64.6%-82.8%), vs those with a single cause, 89.3% (95% confidence interval, 86.4%-92.2%) (P<.001). Multivariate predictors of multiple potential causes were older age, atrial fibrillation, use of cardiac medications, and New York Heart Association classification II, III, and IV. Conclusion: Of the patients evaluated for syncope, 18.4% had multiple potential causes. The presence of multiple potential causes was an independent predictor of increased mortality among patients with syncope.

UR - http://www.scopus.com/inward/record.url?scp=0037377787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037377787&partnerID=8YFLogxK

M3 - Article

C2 - 12683693

AN - SCOPUS:0037377787

VL - 78

SP - 414

EP - 420

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 4

ER -