Pretreatment metabolic tumor volume as a prognostic factor in HPV-associated oropharyngeal cancer in the context of AJCC 8th edition staging

John M. Floberg, Todd A. DeWees, Re I. Chin, Adam A. Garsa, Farrokh Dehdashti, Brian Nussenbaum, Peter J. Oppelt, Douglas R. Adkins, Hiram A. Gay, Wade L. Thorstad

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: This study evaluates the prognostic significance of 18F-fluorodeoxyglucose-positron emission tomography ([F-18]FDG-PET)-derived metabolic tumor volume (MTV) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCCs) in the context of AJCC 8th edition staging. Methods: We performed a retrospective study of HPV-associated OPSCCs treated with postoperative or definitive radiation. The prognostic significance of pretreatment MTV for freedom from recurrence (FFR), freedom from distant metastasis (FFDM), and overall survival (OS) was determined using Kaplan-Meier analysis. Multivariate analysis (MVA) was performed using Cox regression. Results: In this 153-patient cohort, stratifying by the optimum MTV (24 cm3) was prognostic for FFR (P =.0002), FFDM (P =.001), and OS (P <.0001). Metabolic tumor volume (MTV) was prognostic of FFR in AJCC 8th edition stage I/II (P =.03), and stage III patients (P =.04). On multivariate analysis only MTV was a significant factor for OS. Conclusion: Metabolic tumor volume (MTV) is a significant prognostic factor in HPV-associated OPSCCs, independent of AJCC 8th edition stage.

Original languageEnglish (US)
Pages (from-to)2280-2287
Number of pages8
JournalHead and Neck
Volume40
Issue number10
DOIs
StatePublished - Oct 2018

Keywords

  • human papillomavirus (HPV)
  • metabolic tumor volume
  • oropharyngeal cancer
  • positron emission tomography
  • prognostic markers

ASJC Scopus subject areas

  • Otorhinolaryngology

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