Pretreatment metabolic tumor volume as a prognostic factor in HPV-associated oropharyngeal cancer in the context of AJCC 8th edition staging

John M. Floberg, Todd DeWees, Re I. Chin, Adam A. Garsa, Farrokh Dehdashti, Brian Nussenbaum, Peter J. Oppelt, Douglas R. Adkins, Hiram A. Gay, Wade L. Thorstad

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: This study evaluates the prognostic significance of 18F-fluorodeoxyglucose-positron emission tomography ([F-18]FDG-PET)-derived metabolic tumor volume (MTV) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCCs) in the context of AJCC 8th edition staging. Methods: We performed a retrospective study of HPV-associated OPSCCs treated with postoperative or definitive radiation. The prognostic significance of pretreatment MTV for freedom from recurrence (FFR), freedom from distant metastasis (FFDM), and overall survival (OS) was determined using Kaplan-Meier analysis. Multivariate analysis (MVA) was performed using Cox regression. Results: In this 153-patient cohort, stratifying by the optimum MTV (24 cm3) was prognostic for FFR (P = .0002), FFDM (P = .001), and OS (P < .0001). Metabolic tumor volume (MTV) was prognostic of FFR in AJCC 8th edition stage I/II (P = .03), and stage III patients (P = .04). On multivariate analysis only MTV was a significant factor for OS. Conclusion: Metabolic tumor volume (MTV) is a significant prognostic factor in HPV-associated OPSCCs, independent of AJCC 8th edition stage.

Original languageEnglish (US)
JournalHead and Neck
DOIs
StateAccepted/In press - Jan 1 2018

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Oropharyngeal Neoplasms
Tumor Burden
Squamous Cell Carcinoma
Recurrence
Survival
Multivariate Analysis
Neoplasm Metastasis
Fluorodeoxyglucose F18
Kaplan-Meier Estimate
Positron-Emission Tomography
Retrospective Studies
Radiation

Keywords

  • Human papillomavirus (HPV)
  • Metabolic tumor volume
  • Oropharyngeal cancer
  • Positron emission tomography
  • Prognostic markers

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Pretreatment metabolic tumor volume as a prognostic factor in HPV-associated oropharyngeal cancer in the context of AJCC 8th edition staging. / Floberg, John M.; DeWees, Todd; Chin, Re I.; Garsa, Adam A.; Dehdashti, Farrokh; Nussenbaum, Brian; Oppelt, Peter J.; Adkins, Douglas R.; Gay, Hiram A.; Thorstad, Wade L.

In: Head and Neck, 01.01.2018.

Research output: Contribution to journalArticle

Floberg, John M. ; DeWees, Todd ; Chin, Re I. ; Garsa, Adam A. ; Dehdashti, Farrokh ; Nussenbaum, Brian ; Oppelt, Peter J. ; Adkins, Douglas R. ; Gay, Hiram A. ; Thorstad, Wade L. / Pretreatment metabolic tumor volume as a prognostic factor in HPV-associated oropharyngeal cancer in the context of AJCC 8th edition staging. In: Head and Neck. 2018.
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abstract = "Background: This study evaluates the prognostic significance of 18F-fluorodeoxyglucose-positron emission tomography ([F-18]FDG-PET)-derived metabolic tumor volume (MTV) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCCs) in the context of AJCC 8th edition staging. Methods: We performed a retrospective study of HPV-associated OPSCCs treated with postoperative or definitive radiation. The prognostic significance of pretreatment MTV for freedom from recurrence (FFR), freedom from distant metastasis (FFDM), and overall survival (OS) was determined using Kaplan-Meier analysis. Multivariate analysis (MVA) was performed using Cox regression. Results: In this 153-patient cohort, stratifying by the optimum MTV (24 cm3) was prognostic for FFR (P = .0002), FFDM (P = .001), and OS (P < .0001). Metabolic tumor volume (MTV) was prognostic of FFR in AJCC 8th edition stage I/II (P = .03), and stage III patients (P = .04). On multivariate analysis only MTV was a significant factor for OS. Conclusion: Metabolic tumor volume (MTV) is a significant prognostic factor in HPV-associated OPSCCs, independent of AJCC 8th edition stage.",
keywords = "Human papillomavirus (HPV), Metabolic tumor volume, Oropharyngeal cancer, Positron emission tomography, Prognostic markers",
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AU - Floberg, John M.

AU - DeWees, Todd

AU - Chin, Re I.

AU - Garsa, Adam A.

AU - Dehdashti, Farrokh

AU - Nussenbaum, Brian

AU - Oppelt, Peter J.

AU - Adkins, Douglas R.

AU - Gay, Hiram A.

AU - Thorstad, Wade L.

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N2 - Background: This study evaluates the prognostic significance of 18F-fluorodeoxyglucose-positron emission tomography ([F-18]FDG-PET)-derived metabolic tumor volume (MTV) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCCs) in the context of AJCC 8th edition staging. Methods: We performed a retrospective study of HPV-associated OPSCCs treated with postoperative or definitive radiation. The prognostic significance of pretreatment MTV for freedom from recurrence (FFR), freedom from distant metastasis (FFDM), and overall survival (OS) was determined using Kaplan-Meier analysis. Multivariate analysis (MVA) was performed using Cox regression. Results: In this 153-patient cohort, stratifying by the optimum MTV (24 cm3) was prognostic for FFR (P = .0002), FFDM (P = .001), and OS (P < .0001). Metabolic tumor volume (MTV) was prognostic of FFR in AJCC 8th edition stage I/II (P = .03), and stage III patients (P = .04). On multivariate analysis only MTV was a significant factor for OS. Conclusion: Metabolic tumor volume (MTV) is a significant prognostic factor in HPV-associated OPSCCs, independent of AJCC 8th edition stage.

AB - Background: This study evaluates the prognostic significance of 18F-fluorodeoxyglucose-positron emission tomography ([F-18]FDG-PET)-derived metabolic tumor volume (MTV) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCCs) in the context of AJCC 8th edition staging. Methods: We performed a retrospective study of HPV-associated OPSCCs treated with postoperative or definitive radiation. The prognostic significance of pretreatment MTV for freedom from recurrence (FFR), freedom from distant metastasis (FFDM), and overall survival (OS) was determined using Kaplan-Meier analysis. Multivariate analysis (MVA) was performed using Cox regression. Results: In this 153-patient cohort, stratifying by the optimum MTV (24 cm3) was prognostic for FFR (P = .0002), FFDM (P = .001), and OS (P < .0001). Metabolic tumor volume (MTV) was prognostic of FFR in AJCC 8th edition stage I/II (P = .03), and stage III patients (P = .04). On multivariate analysis only MTV was a significant factor for OS. Conclusion: Metabolic tumor volume (MTV) is a significant prognostic factor in HPV-associated OPSCCs, independent of AJCC 8th edition stage.

KW - Human papillomavirus (HPV)

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KW - Oropharyngeal cancer

KW - Positron emission tomography

KW - Prognostic markers

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