Pretreatment cognitive performance predicts survival in patients with leptomeningeal disease

Audrey M. Sherman, Kurt Jaeckle, Christina A. Meyers

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

BACKGROUND. Leptomeningeal disease (LMD) involves the spread of malignant cells from solid tumors to the cerebrospinal fluid or to the leptomeninges. LMD has a very poor prognosis and it is difficult to diagnose and follow with traditional diagnostic tools. The purposes of this study were to characterize cognitive functioning of LMD patients before treatment and to determine if measurement of cognitive functioning could be used to predict survival time. METHODS. Thirty-seven subjects with LMD were administered the Mattis Dementia Rating Scale (DRS) before they received treatment and statistical analyses were performed. RESULTS. The Conceptualization subtest of the DRS was the most sensitive to disease course. It was the only individual subtest to predict survival and it was the most impaired subtest across individual subjects. These results support earlier findings of a frontal-subcortical pattern of dysfunction in LMD patients. Cognitive performance at time of LMD diagnosis predicts survival time. Age and clinical status, two factors often correlated with survival in the cancer literature, did not predict survival time for our LMD population. In addition, there were no correlations between survival time and previous medical history or demographic factors. CONCLUSIONS. Neuropsychological assessment appears to be a valuable tool both for tracking disease course over time and for predicting survival of patients.

Original languageEnglish (US)
Pages (from-to)1311-1316
Number of pages6
JournalCancer
Volume95
Issue number6
DOIs
StatePublished - Sep 15 2002

Fingerprint

Survival
Dementia
Cerebrospinal Fluid
Neoplasms
Demography
Therapeutics
Population

Keywords

  • Cognitive patterns
  • Interleukin-2
  • Leptomeningeal disease
  • Neuropsychology

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pretreatment cognitive performance predicts survival in patients with leptomeningeal disease. / Sherman, Audrey M.; Jaeckle, Kurt; Meyers, Christina A.

In: Cancer, Vol. 95, No. 6, 15.09.2002, p. 1311-1316.

Research output: Contribution to journalArticle

Sherman, Audrey M. ; Jaeckle, Kurt ; Meyers, Christina A. / Pretreatment cognitive performance predicts survival in patients with leptomeningeal disease. In: Cancer. 2002 ; Vol. 95, No. 6. pp. 1311-1316.
@article{2a59c6b9b3af447d9090ebfab8336613,
title = "Pretreatment cognitive performance predicts survival in patients with leptomeningeal disease",
abstract = "BACKGROUND. Leptomeningeal disease (LMD) involves the spread of malignant cells from solid tumors to the cerebrospinal fluid or to the leptomeninges. LMD has a very poor prognosis and it is difficult to diagnose and follow with traditional diagnostic tools. The purposes of this study were to characterize cognitive functioning of LMD patients before treatment and to determine if measurement of cognitive functioning could be used to predict survival time. METHODS. Thirty-seven subjects with LMD were administered the Mattis Dementia Rating Scale (DRS) before they received treatment and statistical analyses were performed. RESULTS. The Conceptualization subtest of the DRS was the most sensitive to disease course. It was the only individual subtest to predict survival and it was the most impaired subtest across individual subjects. These results support earlier findings of a frontal-subcortical pattern of dysfunction in LMD patients. Cognitive performance at time of LMD diagnosis predicts survival time. Age and clinical status, two factors often correlated with survival in the cancer literature, did not predict survival time for our LMD population. In addition, there were no correlations between survival time and previous medical history or demographic factors. CONCLUSIONS. Neuropsychological assessment appears to be a valuable tool both for tracking disease course over time and for predicting survival of patients.",
keywords = "Cognitive patterns, Interleukin-2, Leptomeningeal disease, Neuropsychology",
author = "Sherman, {Audrey M.} and Kurt Jaeckle and Meyers, {Christina A.}",
year = "2002",
month = "9",
day = "15",
doi = "10.1002/cncr.10816",
language = "English (US)",
volume = "95",
pages = "1311--1316",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Pretreatment cognitive performance predicts survival in patients with leptomeningeal disease

AU - Sherman, Audrey M.

AU - Jaeckle, Kurt

AU - Meyers, Christina A.

PY - 2002/9/15

Y1 - 2002/9/15

N2 - BACKGROUND. Leptomeningeal disease (LMD) involves the spread of malignant cells from solid tumors to the cerebrospinal fluid or to the leptomeninges. LMD has a very poor prognosis and it is difficult to diagnose and follow with traditional diagnostic tools. The purposes of this study were to characterize cognitive functioning of LMD patients before treatment and to determine if measurement of cognitive functioning could be used to predict survival time. METHODS. Thirty-seven subjects with LMD were administered the Mattis Dementia Rating Scale (DRS) before they received treatment and statistical analyses were performed. RESULTS. The Conceptualization subtest of the DRS was the most sensitive to disease course. It was the only individual subtest to predict survival and it was the most impaired subtest across individual subjects. These results support earlier findings of a frontal-subcortical pattern of dysfunction in LMD patients. Cognitive performance at time of LMD diagnosis predicts survival time. Age and clinical status, two factors often correlated with survival in the cancer literature, did not predict survival time for our LMD population. In addition, there were no correlations between survival time and previous medical history or demographic factors. CONCLUSIONS. Neuropsychological assessment appears to be a valuable tool both for tracking disease course over time and for predicting survival of patients.

AB - BACKGROUND. Leptomeningeal disease (LMD) involves the spread of malignant cells from solid tumors to the cerebrospinal fluid or to the leptomeninges. LMD has a very poor prognosis and it is difficult to diagnose and follow with traditional diagnostic tools. The purposes of this study were to characterize cognitive functioning of LMD patients before treatment and to determine if measurement of cognitive functioning could be used to predict survival time. METHODS. Thirty-seven subjects with LMD were administered the Mattis Dementia Rating Scale (DRS) before they received treatment and statistical analyses were performed. RESULTS. The Conceptualization subtest of the DRS was the most sensitive to disease course. It was the only individual subtest to predict survival and it was the most impaired subtest across individual subjects. These results support earlier findings of a frontal-subcortical pattern of dysfunction in LMD patients. Cognitive performance at time of LMD diagnosis predicts survival time. Age and clinical status, two factors often correlated with survival in the cancer literature, did not predict survival time for our LMD population. In addition, there were no correlations between survival time and previous medical history or demographic factors. CONCLUSIONS. Neuropsychological assessment appears to be a valuable tool both for tracking disease course over time and for predicting survival of patients.

KW - Cognitive patterns

KW - Interleukin-2

KW - Leptomeningeal disease

KW - Neuropsychology

UR - http://www.scopus.com/inward/record.url?scp=0037105558&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037105558&partnerID=8YFLogxK

U2 - 10.1002/cncr.10816

DO - 10.1002/cncr.10816

M3 - Article

C2 - 12216100

AN - SCOPUS:0037105558

VL - 95

SP - 1311

EP - 1316

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 6

ER -