Pretransplant serum troponin levels are highly predictive of patient and graft survival following liver transplantation

Kymberly D.S. Watt, Elizabeth Coss, Rachel A. Pedersen, Ross Dierkhising, Julie K. Heimbach, Michael R. Charlton

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Optimizing the utility of liver transplantation requires the identification of factors that confer increased risk of posttransplant mortality. Elevated serum troponin (TN) levels are strongly predictive of posttransplant mortality after kidney transplantation. We sought to determine whether pretransplant TN levels were predictive of mortality and graft loss after liver transplantation in 236 liver transplant recipients from 1998 to 2001 with 8.2 years of follow-up. Elevated TN levels [hazard ratio (HR) = 2.19, P = 0.004] and a pretransplant history of cardiovascular disease (CVD; HR = 1.90, P = 0.031) were predictive of patient mortality. Elevated TN levels (HR = 2.44, P < 0.001), a history of CVD (HR = 1.83, P = 0.031), and a combination of elevated TN levels and CVD (HR = 2.75, P = 0.027) were associated with increased graft loss. Multivariate analysis confirmed TN and CVD as independent predictors of mortality and graft loss. CVD (HR = 2.39, P = 0.032) and a combination of elevated TN levels and a history of CVD (HR = 6.67, P < 0.001) were predictive of graft loss within 1 year. Age, smoking, diabetes, hypertension, obesity, creatinine levels, and Model for End-Stage Liver Disease scores were not predictive of posttransplant mortality or graft loss. In summary, elevated pretransplant serum TN levels are strongly predictive of mortality and graft loss after liver transplantation and may be helpful in risk stratification of potential liver transplant recipients.

Original languageEnglish (US)
Pages (from-to)990-998
Number of pages9
JournalLiver Transplantation
Volume16
Issue number8
DOIs
StatePublished - Aug 1 2010

ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation

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    Watt, K. D. S., Coss, E., Pedersen, R. A., Dierkhising, R., Heimbach, J. K., & Charlton, M. R. (2010). Pretransplant serum troponin levels are highly predictive of patient and graft survival following liver transplantation. Liver Transplantation, 16(8), 990-998. https://doi.org/10.1002/lt.22102