Pretransplant risk score for new-onset diabetes after kidney transplantation

Harini M Chakkera, E. Jennifer Weil, Christine M. Swanson, Amylou Dueck, Raymond L. Heilman, Kunam Sudhakar Reddy, Khaled Hamawi, Hasan Khamash, Adyr A. Moss, David C. Mulligan, Nitin Katariya, William C. Knowler

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

OBJECTIVE - New-onset diabetes after kidney transplantation (NODAT) has adverse clinical and economic implications. A risk score for NODAT could help identify research subjects for intervention studies. RESEARCH DESIGN AND METHODS - We conducted a single-center retrospective cohort study using pretransplant clinical and laboratory measurements to construct a risk score for NODAT. NODAT was defined by hemoglobin A 1c (HbA 1c) ≥6.5%, fasting serum glucose ≥126mg/dL, or prescribed therapy for diabetes within 1 year posttransplant. Three multivariate logistic regression models were constructed: 1) standard model, with both continuous and discrete variables; 2) dichotomous model, with continuous variables dichotomized at clinically relevant cut points; and 3) summary score defined as the sum of the points accrued using the terms from the dichotomous model. RESULTS - A total of 316 subjects had seven pretransplant variables with P < 0.10 in univariate logistic regression analyses (age, planned corticosteroid therapy posttransplant, prescription for gout medicine, BMI, fasting glucose and triglycerides, and family history of type 2 diabetes) that were selected for multivariate models. Areas under receiver operating curves for all three models were similar (0.72, 0.71, and 0.70). A simple risk score calculated as the sum of points from the seven variables performed as well as the other two models in identifying risk of NODAT. CONCLUSIONS - A risk score computed from seven simple pretransplant variables can identify risk of NODAT.

Original languageEnglish (US)
Pages (from-to)2141-2145
Number of pages5
JournalDiabetes Care
Volume34
Issue number10
DOIs
StatePublished - Oct 2011

Fingerprint

Kidney Transplantation
Logistic Models
Fasting
Research Subjects
Hemoglobin A
Glucose
Gout
Type 2 Diabetes Mellitus
Prescriptions
Adrenal Cortex Hormones
Triglycerides
Cohort Studies
Research Design
Retrospective Studies
Regression Analysis
Economics
Medicine
Therapeutics
Serum

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Pretransplant risk score for new-onset diabetes after kidney transplantation. / Chakkera, Harini M; Weil, E. Jennifer; Swanson, Christine M.; Dueck, Amylou; Heilman, Raymond L.; Reddy, Kunam Sudhakar; Hamawi, Khaled; Khamash, Hasan; Moss, Adyr A.; Mulligan, David C.; Katariya, Nitin; Knowler, William C.

In: Diabetes Care, Vol. 34, No. 10, 10.2011, p. 2141-2145.

Research output: Contribution to journalArticle

Chakkera, HM, Weil, EJ, Swanson, CM, Dueck, A, Heilman, RL, Reddy, KS, Hamawi, K, Khamash, H, Moss, AA, Mulligan, DC, Katariya, N & Knowler, WC 2011, 'Pretransplant risk score for new-onset diabetes after kidney transplantation', Diabetes Care, vol. 34, no. 10, pp. 2141-2145. https://doi.org/10.2337/dc11-0752
Chakkera, Harini M ; Weil, E. Jennifer ; Swanson, Christine M. ; Dueck, Amylou ; Heilman, Raymond L. ; Reddy, Kunam Sudhakar ; Hamawi, Khaled ; Khamash, Hasan ; Moss, Adyr A. ; Mulligan, David C. ; Katariya, Nitin ; Knowler, William C. / Pretransplant risk score for new-onset diabetes after kidney transplantation. In: Diabetes Care. 2011 ; Vol. 34, No. 10. pp. 2141-2145.
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