Pressure dependency of canine intrarenal blood flow within the range of autoregulation

Lilach O Lerman, M. D. Bentley, M. J. Fiksen-Olsen, D. M. Strick, E. L. Ritman, J. C. Romero

Research output: Contribution to journalArticle

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Abstract

The mechanism of pressure-induced natriuresis remains controversial. To assess whether intracortical or medullary renal blood flows (RBF) change with changes in renal perfusion pressure (RPP), global and regional RBFs were measured using the dynamic spatial reconstructor, a fast computed tomography scanner, in eight anesthetized dogs (group B) within the range of RBF autoregulation (RPP of 153.5 and 114.4 mmHg). Similar measurements were obtained in seven control dogs (group A) in which RPP was not manipulated. In group B, only inner medullary perfusion decreased (from 0.84 to 0.51 ml/min per cm3 of tissue, P = 0.03) with reduction of RPP, whereas global renal, intracortical, and outer medullary perfusions remained unaltered. In group A there was no change in global or regional renal perfusion. The change in inner medullary perfusion in group B (-34.7%) was significantly different (P = 0.021) from that in group A (+27.4%). Global, cortical, and total medullary RBFs (ml/min) and volumes did not change in either group. These results suggest that with changes in RPP, the only detectable change in intrarenal perfusion occurs in the inner medulla.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume268
Issue number3 37-3
StatePublished - 1995

Fingerprint

autoregulation
blood flow
Canidae
Homeostasis
Perfusion
kidneys
Pressure
dogs
Kidney
Renal Circulation
X-Ray Computed Tomography Scanners
Dogs
Natriuresis
scanners
global change
computed tomography

Keywords

  • cortical blood flow
  • dynamic spatial reconstructor
  • medullary blood flow
  • renal blood flow
  • X-ray computed tomography

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physiology

Cite this

Pressure dependency of canine intrarenal blood flow within the range of autoregulation. / Lerman, Lilach O; Bentley, M. D.; Fiksen-Olsen, M. J.; Strick, D. M.; Ritman, E. L.; Romero, J. C.

In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology, Vol. 268, No. 3 37-3, 1995.

Research output: Contribution to journalArticle

Lerman, Lilach O ; Bentley, M. D. ; Fiksen-Olsen, M. J. ; Strick, D. M. ; Ritman, E. L. ; Romero, J. C. / Pressure dependency of canine intrarenal blood flow within the range of autoregulation. In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 1995 ; Vol. 268, No. 3 37-3.
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