Pressure dependency of canine intrarenal blood flow within the range of autoregulation

L. O. Lerman, M. D. Bentley, M. J. Fiksen-Olsen, D. M. Strick, E. L. Ritman, J. C. Romero

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The mechanism of pressure-induced natriuresis remains controversial. To assess whether intracortical or medullary renal blood flows (RBF) change with changes in renal perfusion pressure (RPP), global and regional RBFs were measured using the dynamic spatial reconstructor, a fast computed tomography scanner, in eight anesthetized dogs (group B) within the range of RBF autoregulation (RPP of 153.5 and 114.4 mmHg). Similar measurements were obtained in seven control dogs (group A) in which RPP was not manipulated. In group B, only inner medullary perfusion decreased (from 0.84 to 0.51 ml/min per cm3 of tissue, P = 0.03) with reduction of RPP, whereas global renal, intracortical, and outer medullary perfusions remained unaltered. In group A there was no change in global or regional renal perfusion. The change in inner medullary perfusion in group B (-34.7%) was significantly different (P = 0.021) from that in group A (+27.4%). Global, cortical, and total medullary RBFs (ml/min) and volumes did not change in either group. These results suggest that with changes in RPP, the only detectable change in intrarenal perfusion occurs in the inner medulla.

Original languageEnglish (US)
Pages (from-to)F404-F409
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume268
Issue number3 37-3
DOIs
StatePublished - 1995

Keywords

  • X-ray computed tomography
  • cortical blood flow
  • dynamic spatial reconstructor
  • medullary blood flow
  • renal blood flow

ASJC Scopus subject areas

  • Physiology

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