Abstract
In pithed guinea pigs, general characteristics and the origin of the pressor response to intravenous administration of 5-HT were analysed. The pressor effect of 5-HT (12-200 μg/kg) was prominent and dose-dependent. In animals pretreated with nicotine, reserpine, bretylium or 6-hydroxydopamine the pressor response was markedly diminished. The reduction of the pressor effect produced with bretylium or 6-hydroxydopamine was significantly smaller than that produced with reserpine. It is concluded that, in guinea pigs, unlike in rats, cats and dogs, the pressor response to 6-HT is in part due to the activation of both sympathetic ganglia and the adrenals followed by the release of catecholamines from sympathetic nerve terminals and the adrenal medulla.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 530-531 |
| Number of pages | 2 |
| Journal | IRCS Medical Science |
| Volume | 9 |
| Issue number | 6 |
| State | Published - 1981 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology