In pithed guinea pigs, general characteristics and the origin of the pressor response to intravenous administration of 5-HT were analysed. The pressor effect of 5-HT (12-200 μg/kg) was prominent and dose-dependent. In animals pretreated with nicotine, reserpine, bretylium or 6-hydroxydopamine the pressor response was markedly diminished. The reduction of the pressor effect produced with bretylium or 6-hydroxydopamine was significantly smaller than that produced with reserpine. It is concluded that, in guinea pigs, unlike in rats, cats and dogs, the pressor response to 6-HT is in part due to the activation of both sympathetic ganglia and the adrenals followed by the release of catecholamines from sympathetic nerve terminals and the adrenal medulla.
|Original language||English (US)|
|Number of pages||2|
|Journal||IRCS Medical Science|
|State||Published - Jan 1 1981|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)