Presence of simple renal cysts is associated with increased risk of aortic dissection: A common manifestation of connective tissue degeneration?

Eun Kyoung Kim, E. Ryoung Choi, Bong Gun Song, Shin Yi Jang, Sung Min Ko, Seung Hyuk Choi, Jidong Sung, Kiick Sung, Yeon Hyeon Choe, Jae Kuen Oh, Duk Kyung Kim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: Aortic dissection is a multifactorial disease whose primary pathology is connective tissue degeneration of the aorta's medial layer. It was hypothesised that the presence of renal cysts, another possible manifestation of connective tissue weakness, would be associated with increased risk of aortic dissection. Methods: The incidence of simple renal cysts on CT angiography in 518 patients with aortic dissection (AD group) and 1366 healthy subjects (control group) who underwent CT for routine health screening was compared. To reduce the effects of selection bias and confounding variables, data were adjusted by propensity score matching. Results: The prevalence of simple renal cysts was 37.8% in the AD group and 22.0% in the control group, a statistically significant difference (p<0.0001). The prevalence of renal cysts was even greater in patients with the following characteristics: intramural haematoma, type B dissection, normal blood pressure or advanced age. In the 311 matched cohorts after propensity score matching, the prevalence of simple renal cysts was still significantly higher in the AD group than in the control group (33.8% vs 25.7%, p=0.023). Multivariate analysis confirmed that the presence of renal cysts (OR 1.49, p=0.0245) could be a marker of having a common underlying mechanism with aortic dissection. Conclusion: Patients with aortic dissection have an increased burden of renal cysts compared with healthy controls. This finding suggests that the connective tissue weakness that predisposes patients to renal cysts may be associated with aortic dissection.

Original languageEnglish (US)
Pages (from-to)55-59
Number of pages5
JournalHeart
Volume97
Issue number1
DOIs
StatePublished - Jan 2011

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Connective Tissue
Dissection
Cysts
Kidney
Propensity Score
Control Groups
Confounding Factors (Epidemiology)
Selection Bias
Hematoma
Aorta
Healthy Volunteers
Multivariate Analysis
Pathology
Blood Pressure
Incidence
Health

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Presence of simple renal cysts is associated with increased risk of aortic dissection : A common manifestation of connective tissue degeneration? / Kim, Eun Kyoung; Choi, E. Ryoung; Song, Bong Gun; Jang, Shin Yi; Ko, Sung Min; Choi, Seung Hyuk; Sung, Jidong; Sung, Kiick; Choe, Yeon Hyeon; Oh, Jae Kuen; Kim, Duk Kyung.

In: Heart, Vol. 97, No. 1, 01.2011, p. 55-59.

Research output: Contribution to journalArticle

Kim, EK, Choi, ER, Song, BG, Jang, SY, Ko, SM, Choi, SH, Sung, J, Sung, K, Choe, YH, Oh, JK & Kim, DK 2011, 'Presence of simple renal cysts is associated with increased risk of aortic dissection: A common manifestation of connective tissue degeneration?', Heart, vol. 97, no. 1, pp. 55-59. https://doi.org/10.1136/hrt.2010.205328
Kim, Eun Kyoung ; Choi, E. Ryoung ; Song, Bong Gun ; Jang, Shin Yi ; Ko, Sung Min ; Choi, Seung Hyuk ; Sung, Jidong ; Sung, Kiick ; Choe, Yeon Hyeon ; Oh, Jae Kuen ; Kim, Duk Kyung. / Presence of simple renal cysts is associated with increased risk of aortic dissection : A common manifestation of connective tissue degeneration?. In: Heart. 2011 ; Vol. 97, No. 1. pp. 55-59.
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abstract = "Objective: Aortic dissection is a multifactorial disease whose primary pathology is connective tissue degeneration of the aorta's medial layer. It was hypothesised that the presence of renal cysts, another possible manifestation of connective tissue weakness, would be associated with increased risk of aortic dissection. Methods: The incidence of simple renal cysts on CT angiography in 518 patients with aortic dissection (AD group) and 1366 healthy subjects (control group) who underwent CT for routine health screening was compared. To reduce the effects of selection bias and confounding variables, data were adjusted by propensity score matching. Results: The prevalence of simple renal cysts was 37.8{\%} in the AD group and 22.0{\%} in the control group, a statistically significant difference (p<0.0001). The prevalence of renal cysts was even greater in patients with the following characteristics: intramural haematoma, type B dissection, normal blood pressure or advanced age. In the 311 matched cohorts after propensity score matching, the prevalence of simple renal cysts was still significantly higher in the AD group than in the control group (33.8{\%} vs 25.7{\%}, p=0.023). Multivariate analysis confirmed that the presence of renal cysts (OR 1.49, p=0.0245) could be a marker of having a common underlying mechanism with aortic dissection. Conclusion: Patients with aortic dissection have an increased burden of renal cysts compared with healthy controls. This finding suggests that the connective tissue weakness that predisposes patients to renal cysts may be associated with aortic dissection.",
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AU - Kim, Eun Kyoung

AU - Choi, E. Ryoung

AU - Song, Bong Gun

AU - Jang, Shin Yi

AU - Ko, Sung Min

AU - Choi, Seung Hyuk

AU - Sung, Jidong

AU - Sung, Kiick

AU - Choe, Yeon Hyeon

AU - Oh, Jae Kuen

AU - Kim, Duk Kyung

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N2 - Objective: Aortic dissection is a multifactorial disease whose primary pathology is connective tissue degeneration of the aorta's medial layer. It was hypothesised that the presence of renal cysts, another possible manifestation of connective tissue weakness, would be associated with increased risk of aortic dissection. Methods: The incidence of simple renal cysts on CT angiography in 518 patients with aortic dissection (AD group) and 1366 healthy subjects (control group) who underwent CT for routine health screening was compared. To reduce the effects of selection bias and confounding variables, data were adjusted by propensity score matching. Results: The prevalence of simple renal cysts was 37.8% in the AD group and 22.0% in the control group, a statistically significant difference (p<0.0001). The prevalence of renal cysts was even greater in patients with the following characteristics: intramural haematoma, type B dissection, normal blood pressure or advanced age. In the 311 matched cohorts after propensity score matching, the prevalence of simple renal cysts was still significantly higher in the AD group than in the control group (33.8% vs 25.7%, p=0.023). Multivariate analysis confirmed that the presence of renal cysts (OR 1.49, p=0.0245) could be a marker of having a common underlying mechanism with aortic dissection. Conclusion: Patients with aortic dissection have an increased burden of renal cysts compared with healthy controls. This finding suggests that the connective tissue weakness that predisposes patients to renal cysts may be associated with aortic dissection.

AB - Objective: Aortic dissection is a multifactorial disease whose primary pathology is connective tissue degeneration of the aorta's medial layer. It was hypothesised that the presence of renal cysts, another possible manifestation of connective tissue weakness, would be associated with increased risk of aortic dissection. Methods: The incidence of simple renal cysts on CT angiography in 518 patients with aortic dissection (AD group) and 1366 healthy subjects (control group) who underwent CT for routine health screening was compared. To reduce the effects of selection bias and confounding variables, data were adjusted by propensity score matching. Results: The prevalence of simple renal cysts was 37.8% in the AD group and 22.0% in the control group, a statistically significant difference (p<0.0001). The prevalence of renal cysts was even greater in patients with the following characteristics: intramural haematoma, type B dissection, normal blood pressure or advanced age. In the 311 matched cohorts after propensity score matching, the prevalence of simple renal cysts was still significantly higher in the AD group than in the control group (33.8% vs 25.7%, p=0.023). Multivariate analysis confirmed that the presence of renal cysts (OR 1.49, p=0.0245) could be a marker of having a common underlying mechanism with aortic dissection. Conclusion: Patients with aortic dissection have an increased burden of renal cysts compared with healthy controls. This finding suggests that the connective tissue weakness that predisposes patients to renal cysts may be associated with aortic dissection.

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