Presence of monoclonal free light chains in the serum predicts risk of progression in monoclonal gammopathy of undetermined significance

S Vincent Rajkumar, Robert A. Kyle, Terry M Therneau, Raynell J. Clark, Arthur R. Bradwell, L. Joseph Melton, Dirk R. Larson, Matthew F. Plevak, Jerry A. Katzmann

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

We hypothesized that the presence of monoclonal free light chains (FLC) in the serum of patients with monoclonal gammopathy of undetermined significance (MGUS) is a marker of clonal evolution and a risk factor for progression. Forty-seven patients with MGUS and documented progression to myeloma or related malignancy were compared with 50 age- and gender-matched patients with MGUS and no evidence of progression after 5 or more years of follow-up. The presence of an abnormal kappa/lambda FLC ratio in the serum was associated with a higher risk of MGUS progression (relative risk 2.5; 95% confidence interval: 1.6-4.0; P < 0.001).

Original languageEnglish (US)
Pages (from-to)308-310
Number of pages3
JournalBritish Journal of Haematology
Volume127
Issue number3
DOIs
StatePublished - Nov 2004

Fingerprint

Monoclonal Gammopathy of Undetermined Significance
Light
Serum
Clonal Evolution
Confidence Intervals
Neoplasms

Keywords

  • Kappa light chains
  • Kappa/lambda free light chain ratio
  • Lambda light chains
  • Monoclonal gammopathy of undetermined significance
  • Progression

ASJC Scopus subject areas

  • Hematology

Cite this

Presence of monoclonal free light chains in the serum predicts risk of progression in monoclonal gammopathy of undetermined significance. / Rajkumar, S Vincent; Kyle, Robert A.; Therneau, Terry M; Clark, Raynell J.; Bradwell, Arthur R.; Melton, L. Joseph; Larson, Dirk R.; Plevak, Matthew F.; Katzmann, Jerry A.

In: British Journal of Haematology, Vol. 127, No. 3, 11.2004, p. 308-310.

Research output: Contribution to journalArticle

Rajkumar, S Vincent ; Kyle, Robert A. ; Therneau, Terry M ; Clark, Raynell J. ; Bradwell, Arthur R. ; Melton, L. Joseph ; Larson, Dirk R. ; Plevak, Matthew F. ; Katzmann, Jerry A. / Presence of monoclonal free light chains in the serum predicts risk of progression in monoclonal gammopathy of undetermined significance. In: British Journal of Haematology. 2004 ; Vol. 127, No. 3. pp. 308-310.
@article{de5457adff5b470db73fe098a8284847,
title = "Presence of monoclonal free light chains in the serum predicts risk of progression in monoclonal gammopathy of undetermined significance",
abstract = "We hypothesized that the presence of monoclonal free light chains (FLC) in the serum of patients with monoclonal gammopathy of undetermined significance (MGUS) is a marker of clonal evolution and a risk factor for progression. Forty-seven patients with MGUS and documented progression to myeloma or related malignancy were compared with 50 age- and gender-matched patients with MGUS and no evidence of progression after 5 or more years of follow-up. The presence of an abnormal kappa/lambda FLC ratio in the serum was associated with a higher risk of MGUS progression (relative risk 2.5; 95{\%} confidence interval: 1.6-4.0; P < 0.001).",
keywords = "Kappa light chains, Kappa/lambda free light chain ratio, Lambda light chains, Monoclonal gammopathy of undetermined significance, Progression",
author = "Rajkumar, {S Vincent} and Kyle, {Robert A.} and Therneau, {Terry M} and Clark, {Raynell J.} and Bradwell, {Arthur R.} and Melton, {L. Joseph} and Larson, {Dirk R.} and Plevak, {Matthew F.} and Katzmann, {Jerry A.}",
year = "2004",
month = "11",
doi = "10.1111/j.1365-2141.2004.05169.x",
language = "English (US)",
volume = "127",
pages = "308--310",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Presence of monoclonal free light chains in the serum predicts risk of progression in monoclonal gammopathy of undetermined significance

AU - Rajkumar, S Vincent

AU - Kyle, Robert A.

AU - Therneau, Terry M

AU - Clark, Raynell J.

AU - Bradwell, Arthur R.

AU - Melton, L. Joseph

AU - Larson, Dirk R.

AU - Plevak, Matthew F.

AU - Katzmann, Jerry A.

PY - 2004/11

Y1 - 2004/11

N2 - We hypothesized that the presence of monoclonal free light chains (FLC) in the serum of patients with monoclonal gammopathy of undetermined significance (MGUS) is a marker of clonal evolution and a risk factor for progression. Forty-seven patients with MGUS and documented progression to myeloma or related malignancy were compared with 50 age- and gender-matched patients with MGUS and no evidence of progression after 5 or more years of follow-up. The presence of an abnormal kappa/lambda FLC ratio in the serum was associated with a higher risk of MGUS progression (relative risk 2.5; 95% confidence interval: 1.6-4.0; P < 0.001).

AB - We hypothesized that the presence of monoclonal free light chains (FLC) in the serum of patients with monoclonal gammopathy of undetermined significance (MGUS) is a marker of clonal evolution and a risk factor for progression. Forty-seven patients with MGUS and documented progression to myeloma or related malignancy were compared with 50 age- and gender-matched patients with MGUS and no evidence of progression after 5 or more years of follow-up. The presence of an abnormal kappa/lambda FLC ratio in the serum was associated with a higher risk of MGUS progression (relative risk 2.5; 95% confidence interval: 1.6-4.0; P < 0.001).

KW - Kappa light chains

KW - Kappa/lambda free light chain ratio

KW - Lambda light chains

KW - Monoclonal gammopathy of undetermined significance

KW - Progression

UR - http://www.scopus.com/inward/record.url?scp=7944231889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7944231889&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2141.2004.05169.x

DO - 10.1111/j.1365-2141.2004.05169.x

M3 - Article

VL - 127

SP - 308

EP - 310

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 3

ER -