Presence of monoclonal free light chains in the serum predicts risk of progression in monoclonal gammopathy of undetermined significance

S. Vincent Rajkumar; Robert A. Kyle; Terry M. Therneau; Raynell J. Clark; Arthur R. Bradwell; L. Joseph Melton; Dirk R. Larson; Matthew F. Plevak; Jerry A. Katzmann

doi:10.1111/j.1365-2141.2004.05169.x

Presence of monoclonal free light chains in the serum predicts risk of progression in monoclonal gammopathy of undetermined significance

S. Vincent Rajkumar, Robert A. Kyle, Terry M. Therneau, Raynell J. Clark, Arthur R. Bradwell, L. Joseph Melton, Dirk R. Larson, Matthew F. Plevak, Jerry A. Katzmann

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60 Scopus citations

Abstract

We hypothesized that the presence of monoclonal free light chains (FLC) in the serum of patients with monoclonal gammopathy of undetermined significance (MGUS) is a marker of clonal evolution and a risk factor for progression. Forty-seven patients with MGUS and documented progression to myeloma or related malignancy were compared with 50 age- and gender-matched patients with MGUS and no evidence of progression after 5 or more years of follow-up. The presence of an abnormal kappa/lambda FLC ratio in the serum was associated with a higher risk of MGUS progression (relative risk 2.5; 95% confidence interval: 1.6-4.0; P < 0.001).

Original language	English (US)
Pages (from-to)	308-310
Number of pages	3
Journal	British journal of haematology
Volume	127
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2141.2004.05169.x
State	Published - Nov 2004

Keywords

Kappa light chains
Kappa/lambda free light chain ratio
Lambda light chains
Monoclonal gammopathy of undetermined significance
Progression

ASJC Scopus subject areas

Hematology

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10.1111/j.1365-2141.2004.05169.x

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Rajkumar, S. V., Kyle, R. A., Therneau, T. M., Clark, R. J., Bradwell, A. R., Melton, L. J., Larson, D. R., Plevak, M. F., & Katzmann, J. A. (2004). Presence of monoclonal free light chains in the serum predicts risk of progression in monoclonal gammopathy of undetermined significance. British journal of haematology, 127(3), 308-310. https://doi.org/10.1111/j.1365-2141.2004.05169.x

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title = "Presence of monoclonal free light chains in the serum predicts risk of progression in monoclonal gammopathy of undetermined significance",

abstract = "We hypothesized that the presence of monoclonal free light chains (FLC) in the serum of patients with monoclonal gammopathy of undetermined significance (MGUS) is a marker of clonal evolution and a risk factor for progression. Forty-seven patients with MGUS and documented progression to myeloma or related malignancy were compared with 50 age- and gender-matched patients with MGUS and no evidence of progression after 5 or more years of follow-up. The presence of an abnormal kappa/lambda FLC ratio in the serum was associated with a higher risk of MGUS progression (relative risk 2.5; 95% confidence interval: 1.6-4.0; P < 0.001).",

keywords = "Kappa light chains, Kappa/lambda free light chain ratio, Lambda light chains, Monoclonal gammopathy of undetermined significance, Progression",

author = "Rajkumar, {S. Vincent} and Kyle, {Robert A.} and Therneau, {Terry M.} and Clark, {Raynell J.} and Bradwell, {Arthur R.} and Melton, {L. Joseph} and Larson, {Dirk R.} and Plevak, {Matthew F.} and Katzmann, {Jerry A.}",

year = "2004",

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doi = "10.1111/j.1365-2141.2004.05169.x",

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AU - Rajkumar, S. Vincent

AU - Kyle, Robert A.

AU - Therneau, Terry M.

AU - Clark, Raynell J.

AU - Bradwell, Arthur R.

AU - Melton, L. Joseph

AU - Larson, Dirk R.

AU - Plevak, Matthew F.

AU - Katzmann, Jerry A.

PY - 2004/11

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AB - We hypothesized that the presence of monoclonal free light chains (FLC) in the serum of patients with monoclonal gammopathy of undetermined significance (MGUS) is a marker of clonal evolution and a risk factor for progression. Forty-seven patients with MGUS and documented progression to myeloma or related malignancy were compared with 50 age- and gender-matched patients with MGUS and no evidence of progression after 5 or more years of follow-up. The presence of an abnormal kappa/lambda FLC ratio in the serum was associated with a higher risk of MGUS progression (relative risk 2.5; 95% confidence interval: 1.6-4.0; P < 0.001).

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KW - Kappa/lambda free light chain ratio

KW - Lambda light chains

KW - Monoclonal gammopathy of undetermined significance

KW - Progression

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Presence of monoclonal free light chains in the serum predicts risk of progression in monoclonal gammopathy of undetermined significance

Abstract

Keywords

ASJC Scopus subject areas

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