Presence and expression of human herpesvirus 6 in peripheral blood mononuclear cells of s100-positive, t cell chronic lymphoproliferative disease

Daniel K. Braun, Philip E. Pellett, Curtis A. Hanson

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

S100-positive, T cell chronic lymphoproliferative disease (S100-CLPD) is a rare and aggressive hematologic disorder in which the cytoplasmic protein S100 is expressed at high levels in abnormal lymphocytes. Using a DNA probe specific for human herpesvirus 6 (HHV-6), 2 cases of S100-CLPD were examined by DNA and RNA hybridization analysis. The results indicated that HHV-6 DNA was present in uncultured peripheral blood mononuclear cells (PBMC) and that a 1.3-kb viral transcript was expressed in both cases. Analysis of flow-sorted PBMC from 1 case demonstrated that HHV-6 DNA was present exclusively in the S100-positive fraction. Studies using other HHV-6 DNA probes suggested infection with HHV-6 variant B in both cases. Hybridization studies using DNA from PBMC of 27 cases of T cell chronic lymphoproliferative disease of other types showed no evidence of HHV-6. These studies suggest a possible specific association of HHV-6 with the unusual disorder S100-CLPD.

Original languageEnglish (US)
Pages (from-to)1351-1355
Number of pages5
JournalJournal of Infectious Diseases
Volume171
Issue number5
DOIs
StatePublished - May 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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