Preoperative Radiation for Soft Tissue Sarcomas: How Much Is Needed?

Safia K. Ahmed, Ivy A. Petersen

Research output: Contribution to journalReview articlepeer-review

Abstract

Preoperative radiation therapy is an important component of curative treatment for extremity and superficial trunk soft tissue sarcomas. It has traditionally been delivered to a dose of 50 Gy in 2 Gy fractions over 5 weeks. With significant advances in the multidisciplinary approach to soft tissue sarcomas, preoperative radiation therapy may be omitted for certain cases, delivered over a shortened period of time (1–3 weeks), deintensified for myxoid liposarcomas, or combined with systemic therapy to improve the therapeutic ratio. This article reviews the innovative preoperative radiation therapy strategies currently used to treat extremity and superficial trunk soft tissue sarcomas.

Original languageEnglish (US)
Pages (from-to)68-77
Number of pages10
JournalCurrent treatment options in oncology
Volume23
Issue number1
DOIs
StatePublished - Jan 2022

Keywords

  • Combination therapy
  • Dose deintensification
  • Hypofractionation
  • Omission of radiation therapy
  • Preoperative radiation therapy
  • Soft tissue sarcoma

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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