Preoperative N-terminal pro-B type natriuretic peptide level can predict the regression of left ventricular mass after valvular surgery in patients with chronic severe mitral regurgitation: One-year follow-up

Bong Gun Song, Sung Ji Park, Eun Seok Jeon, Soo Hee Choi, Young Keun On, Jin Oh Choi, Sang Chol Lee, Seung Woo Park, Duk Kyung Kim, Jae K. Oh, Ki Ick Sung, Pyo Won Park

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Abstract

Background: The aim of this study was to investigate preoperative clinical and echocardiographic characteristics and N-terminal pro-B type natriuretic peptide (NT-proBNP) levels as prognostic factors for regression of the left ventricular (LV) mass after valvular surgery in patients with chronic severe mitral regurgitation (MR). Methods: One hundred seventeen patients undergoing surgery for chronic severe MR were included. Plasma NT-proBNP measurements and echocardiography were performed preoperatively, immediately postoperatively, and at six and 12 months after surgery. Any regression of the LV mass was evaluated by echocardiography. Results: During follow-up, 90 patients (77%) were classified as an LV mass regression group (LVMR), defined as having a postoperative reduction in LV mass indexed against body surface area (LVMI). The remaining 27 (23%) patients were classified as NON-LVMR. The LVMR group was younger (p = 0.029) and had significantly lower ratios of patients with hypertension (p = 0.045) and diuretic use (p = 0.005) than the NON-LVMR group. They also had lower levels of NT-proBNP (median: 446.4 pg/ml versus 1394.0 pg/ml, p = 0.001). In multivariate analysis, higher preoperative NT-proBNP levels were independent predictors of no significant regression of the LV mass (odds ratio = 1.731, 95% confidence intervals 1.052-2.844, p = 0.010). Conclusions: A lower preoperative NT-proBNP level predicted the regression of LV mass after valvular surgery in patients with chronic severe MR. This measure could be used as a biomarker for predicting the postoperative course in such patients.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalInternational Journal of Cardiology
Volume145
Issue number2
DOIs
StatePublished - Nov 19 2010

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Keywords

  • Left ventricular mass
  • Left ventricular remodeling
  • Mitral regurgitation
  • Mitral valve surgery
  • NT-proBNP

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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