Preoperative motor strength and time to surgery are the most important predictors of improvement in foot drop due to degenerative lumbar disease

Mohamed MacKi, Sbaa Syeda, Panagiotis Kerezoudis, Ziya L. Gokaslan, Ali Bydon, Mohamad Bydon

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective Palsy of dorsiflexion, or foot drop, may be due to degenerative lumbar disease and amenable to posterior spinal decompression. The objective of this study is to measure prognostic factors of and time to foot drop improvement after posterior lumbar decompression. Methods We retrospectively reviewed 71 patients undergoing first-time, posterior lumbar decompression for foot drop due to degenerative spinal disease. Patient sex, age, comorbidities (Charlson Comorbidity Index), preoperative anterior tibialis strength (manual muscle testing, MMT), and duration of foot drop were ascertained from clinical notes. Prognostic factors affecting foot drop improvement were calculated with a discrete time proportional hazards model, in which follow-up times and outcome measures were binned into six time intervals: 1 week, 6 weeks, 3 months, 6 months, 1 year, and ≥ 1 year. Results Of the 71 patients, the mean age was 54.6 ± 16.0 years, and 66.2% (n = 47) were males. The mean Charlson Comorbidity Index was 2.42. During a mean follow-up of 30.4 months, dorsiflexion function improved postoperatively in 73.2% (n = 52) of patients. The median time to surgery from onset of foot drop was within 6 weeks, and the median preoperative MMT strength of patients with foot drop improvement was 3. Following a discrete-time proportional hazards model, duration of anterior tibialis palsy (HR = 0.67, P = 0.004) and preoperative muscle strength (HR = 1.10, P = 0.010) were significant predictors of foot drop improvement. Following an adjusted Kaplan-Meier analysis, the median time to foot drop improvement was within 6 weeks of surgical intervention. Conclusions Preoperative muscle strength and palsy duration were statistically significant predictors of foot drop improvement. Furthermore, the median time to improvement was 6 weeks.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalJournal of the Neurological Sciences
Volume361
DOIs
StatePublished - Feb 15 2016

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Foot
Muscle Strength
Decompression
Paralysis
Comorbidity
Proportional Hazards Models
Spinal Diseases
Kaplan-Meier Estimate
Outcome Assessment (Health Care)

Keywords

  • Degenerative lumbar disease
  • Foot drop
  • Motor strength improvement
  • Spine surgery

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Preoperative motor strength and time to surgery are the most important predictors of improvement in foot drop due to degenerative lumbar disease. / MacKi, Mohamed; Syeda, Sbaa; Kerezoudis, Panagiotis; Gokaslan, Ziya L.; Bydon, Ali; Bydon, Mohamad.

In: Journal of the Neurological Sciences, Vol. 361, 15.02.2016, p. 133-136.

Research output: Contribution to journalArticle

MacKi, Mohamed ; Syeda, Sbaa ; Kerezoudis, Panagiotis ; Gokaslan, Ziya L. ; Bydon, Ali ; Bydon, Mohamad. / Preoperative motor strength and time to surgery are the most important predictors of improvement in foot drop due to degenerative lumbar disease. In: Journal of the Neurological Sciences. 2016 ; Vol. 361. pp. 133-136.
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abstract = "Objective Palsy of dorsiflexion, or foot drop, may be due to degenerative lumbar disease and amenable to posterior spinal decompression. The objective of this study is to measure prognostic factors of and time to foot drop improvement after posterior lumbar decompression. Methods We retrospectively reviewed 71 patients undergoing first-time, posterior lumbar decompression for foot drop due to degenerative spinal disease. Patient sex, age, comorbidities (Charlson Comorbidity Index), preoperative anterior tibialis strength (manual muscle testing, MMT), and duration of foot drop were ascertained from clinical notes. Prognostic factors affecting foot drop improvement were calculated with a discrete time proportional hazards model, in which follow-up times and outcome measures were binned into six time intervals: 1 week, 6 weeks, 3 months, 6 months, 1 year, and ≥ 1 year. Results Of the 71 patients, the mean age was 54.6 ± 16.0 years, and 66.2{\%} (n = 47) were males. The mean Charlson Comorbidity Index was 2.42. During a mean follow-up of 30.4 months, dorsiflexion function improved postoperatively in 73.2{\%} (n = 52) of patients. The median time to surgery from onset of foot drop was within 6 weeks, and the median preoperative MMT strength of patients with foot drop improvement was 3. Following a discrete-time proportional hazards model, duration of anterior tibialis palsy (HR = 0.67, P = 0.004) and preoperative muscle strength (HR = 1.10, P = 0.010) were significant predictors of foot drop improvement. Following an adjusted Kaplan-Meier analysis, the median time to foot drop improvement was within 6 weeks of surgical intervention. Conclusions Preoperative muscle strength and palsy duration were statistically significant predictors of foot drop improvement. Furthermore, the median time to improvement was 6 weeks.",
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AU - Bydon, Ali

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N2 - Objective Palsy of dorsiflexion, or foot drop, may be due to degenerative lumbar disease and amenable to posterior spinal decompression. The objective of this study is to measure prognostic factors of and time to foot drop improvement after posterior lumbar decompression. Methods We retrospectively reviewed 71 patients undergoing first-time, posterior lumbar decompression for foot drop due to degenerative spinal disease. Patient sex, age, comorbidities (Charlson Comorbidity Index), preoperative anterior tibialis strength (manual muscle testing, MMT), and duration of foot drop were ascertained from clinical notes. Prognostic factors affecting foot drop improvement were calculated with a discrete time proportional hazards model, in which follow-up times and outcome measures were binned into six time intervals: 1 week, 6 weeks, 3 months, 6 months, 1 year, and ≥ 1 year. Results Of the 71 patients, the mean age was 54.6 ± 16.0 years, and 66.2% (n = 47) were males. The mean Charlson Comorbidity Index was 2.42. During a mean follow-up of 30.4 months, dorsiflexion function improved postoperatively in 73.2% (n = 52) of patients. The median time to surgery from onset of foot drop was within 6 weeks, and the median preoperative MMT strength of patients with foot drop improvement was 3. Following a discrete-time proportional hazards model, duration of anterior tibialis palsy (HR = 0.67, P = 0.004) and preoperative muscle strength (HR = 1.10, P = 0.010) were significant predictors of foot drop improvement. Following an adjusted Kaplan-Meier analysis, the median time to foot drop improvement was within 6 weeks of surgical intervention. Conclusions Preoperative muscle strength and palsy duration were statistically significant predictors of foot drop improvement. Furthermore, the median time to improvement was 6 weeks.

AB - Objective Palsy of dorsiflexion, or foot drop, may be due to degenerative lumbar disease and amenable to posterior spinal decompression. The objective of this study is to measure prognostic factors of and time to foot drop improvement after posterior lumbar decompression. Methods We retrospectively reviewed 71 patients undergoing first-time, posterior lumbar decompression for foot drop due to degenerative spinal disease. Patient sex, age, comorbidities (Charlson Comorbidity Index), preoperative anterior tibialis strength (manual muscle testing, MMT), and duration of foot drop were ascertained from clinical notes. Prognostic factors affecting foot drop improvement were calculated with a discrete time proportional hazards model, in which follow-up times and outcome measures were binned into six time intervals: 1 week, 6 weeks, 3 months, 6 months, 1 year, and ≥ 1 year. Results Of the 71 patients, the mean age was 54.6 ± 16.0 years, and 66.2% (n = 47) were males. The mean Charlson Comorbidity Index was 2.42. During a mean follow-up of 30.4 months, dorsiflexion function improved postoperatively in 73.2% (n = 52) of patients. The median time to surgery from onset of foot drop was within 6 weeks, and the median preoperative MMT strength of patients with foot drop improvement was 3. Following a discrete-time proportional hazards model, duration of anterior tibialis palsy (HR = 0.67, P = 0.004) and preoperative muscle strength (HR = 1.10, P = 0.010) were significant predictors of foot drop improvement. Following an adjusted Kaplan-Meier analysis, the median time to foot drop improvement was within 6 weeks of surgical intervention. Conclusions Preoperative muscle strength and palsy duration were statistically significant predictors of foot drop improvement. Furthermore, the median time to improvement was 6 weeks.

KW - Degenerative lumbar disease

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KW - Motor strength improvement

KW - Spine surgery

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