Preoperative assessment as a predictor of mortality and morbidity after lung resection

J. Markos, B. P. Mullan, D. R. Hillman, A. W. Musk, V. F. Antico, F. T. Lovegrove, M. J. Carter, K. E. Finucane

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367 Scopus citations

Abstract

To refine the functional guidelines for operability for lung resection, we prospectively studied 55 consecutive patients with suspected lung malignancy thought to be surgically resectable. Lung function and exercise capacity were measured preoperatively and at 3 and 12 months postoperatively. Preoperative pulmonary scintigraphy was used to calculate the contribution to overall function by the affected lung or lobe and to predict postoperative lung function. Pneumonectomy was performed in 18 patients, lobectomy in 29, and thoracotomy without resection in six. No surgery was attempted in two patients who were considered functionally inoperable. Cardiopulmonary complications developed in 16 patients within 30 days of surgery, including three deaths. The predictions of postoperative function correlated well with the measured values at 3 months. For FEV1, r = 0.51 in pneumonectomy (p < 0.05) and 0.89 in lobectomy (p < 0.001). Predicted postoperative FEV1 (FEV1-ppo), diffusing capacity (DL(CO)), predicted postoperative DL(CO) (DL(CO)-ppo) and exercise-induced arterial O2 desaturation (ΔSa(O2)) were predictive of postoperative complications including death and respiratory failure. In patients who underwent pneumonectomy, the best predictor of death was FEV1-ppo. The predictions were enhanced by expressing the value as a percentage of the predicted normal value (% pred) rather than in absolute units. For the entire surgical group a FEV1-ppo ≥ 40% pred was associated with no postoperative mortality (n = 47), whereas a value < 40% pred was associated with a 50% mortality (n = 6), suggesting that resection is feasible when FEV1-ppo is ≥ 40% pred. When it is < 40% pred, DL(CO), DL(CO)-ppo, and ΔSa(O2) appear to be useful in further assessing the risks of surgery.

Original languageEnglish (US)
Pages (from-to)902-910
Number of pages9
JournalAmerican Review of Respiratory Disease
Volume139
Issue number4 I
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Markos, J., Mullan, B. P., Hillman, D. R., Musk, A. W., Antico, V. F., Lovegrove, F. T., Carter, M. J., & Finucane, K. E. (1989). Preoperative assessment as a predictor of mortality and morbidity after lung resection. American Review of Respiratory Disease, 139(4 I), 902-910. https://doi.org/10.1164/ajrccm/139.4.902