Preoperative and perioperative predictors of the need for renal replacement therapy after orthotopic liver transplantation

Edmund Q. Sanchez, Thomas A. Gonwa, Marlon F. Levy, Robert M. Goldstein, Martin Mai, Steven R. Hays, Larry B. Melton, Giovanna Saracino, Goran B. Klintmalm

Research output: Contribution to journalArticle

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Abstract

Background. Acute renal failure developing after orthotopic liver transplantation (OLTx) requiring renal replacement heralds a poor prognosis. Our center has previously reported a 1-year survival of only 41.8%. We undertook this study to determine whether we could identify preoperative and perioperative factors that would predict which patients are at risk. Methods. OLTxs performed between January 1, 1996, and December 31, 2001, were included in our retrospective database review. Combined kidney-liver transplants or patients with preoperative renal replacement therapy (RRT) were excluded. A total of 724 OLTxs were studied, which were divided into group I: no RRT, n=637; group II: hemodialysis only post-OLTx, n=17; and group III: continuous RRT post-OLTx, n=70. Univariate and stepwise logistic multivariate analyses were performed. Results. Preoperative serum creatinine greater than 1.9 mg/dL (odds ratio [OR] 3.57), preoperative blood urea nitrogen greater than 27 mg/dL (OR 2.68), intensive care unit stay more than 3 days (OR 10.23), and Model for End-Stage Liver Disease score greater than 21 (OR 2.5) were significant. A clinical prediction model was constructed: probability of requiring dialysis posttransplant=(-2.4586+1.2726 [creatinine >1.9] + 0.9858 [blood urea nitrogen >27] + 0.4574 [Model for End-Stage Liver Disease score >21] + 1.1625 [intensive care unit days >3]). A clinical prediction rule for patients with a score greater than 0.12 was applied to OLTx recipients who underwent transplantation in 2002. A total of 15 of 20 patients who received RRT and 111 of 121 who did not were correctly classified with the model. Conclusions. This model allowed us to identify patients at high risk for developing the need for RRT postoperatively. Strategies for these patients to prevent or ameliorate acute renal failure and reduce the need for RRT postoperatively are needed.

Original languageEnglish (US)
Pages (from-to)1048-1054
Number of pages7
JournalTransplantation
Volume78
Issue number7
DOIs
StatePublished - Oct 15 2004

Fingerprint

Renal Replacement Therapy
Liver Transplantation
Odds Ratio
End Stage Liver Disease
Blood Urea Nitrogen
Acute Kidney Injury
Intensive Care Units
Creatinine
Kidney
Decision Support Techniques
Renal Dialysis
Dialysis
Multivariate Analysis
Transplantation
Databases
Transplants
Survival
Liver
Serum

Keywords

  • Liver transplantation
  • Renal failure

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Preoperative and perioperative predictors of the need for renal replacement therapy after orthotopic liver transplantation. / Sanchez, Edmund Q.; Gonwa, Thomas A.; Levy, Marlon F.; Goldstein, Robert M.; Mai, Martin; Hays, Steven R.; Melton, Larry B.; Saracino, Giovanna; Klintmalm, Goran B.

In: Transplantation, Vol. 78, No. 7, 15.10.2004, p. 1048-1054.

Research output: Contribution to journalArticle

Sanchez, EQ, Gonwa, TA, Levy, MF, Goldstein, RM, Mai, M, Hays, SR, Melton, LB, Saracino, G & Klintmalm, GB 2004, 'Preoperative and perioperative predictors of the need for renal replacement therapy after orthotopic liver transplantation', Transplantation, vol. 78, no. 7, pp. 1048-1054. https://doi.org/10.1097/01.TP.0000137176.95730.5B
Sanchez, Edmund Q. ; Gonwa, Thomas A. ; Levy, Marlon F. ; Goldstein, Robert M. ; Mai, Martin ; Hays, Steven R. ; Melton, Larry B. ; Saracino, Giovanna ; Klintmalm, Goran B. / Preoperative and perioperative predictors of the need for renal replacement therapy after orthotopic liver transplantation. In: Transplantation. 2004 ; Vol. 78, No. 7. pp. 1048-1054.
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abstract = "Background. Acute renal failure developing after orthotopic liver transplantation (OLTx) requiring renal replacement heralds a poor prognosis. Our center has previously reported a 1-year survival of only 41.8{\%}. We undertook this study to determine whether we could identify preoperative and perioperative factors that would predict which patients are at risk. Methods. OLTxs performed between January 1, 1996, and December 31, 2001, were included in our retrospective database review. Combined kidney-liver transplants or patients with preoperative renal replacement therapy (RRT) were excluded. A total of 724 OLTxs were studied, which were divided into group I: no RRT, n=637; group II: hemodialysis only post-OLTx, n=17; and group III: continuous RRT post-OLTx, n=70. Univariate and stepwise logistic multivariate analyses were performed. Results. Preoperative serum creatinine greater than 1.9 mg/dL (odds ratio [OR] 3.57), preoperative blood urea nitrogen greater than 27 mg/dL (OR 2.68), intensive care unit stay more than 3 days (OR 10.23), and Model for End-Stage Liver Disease score greater than 21 (OR 2.5) were significant. A clinical prediction model was constructed: probability of requiring dialysis posttransplant=(-2.4586+1.2726 [creatinine >1.9] + 0.9858 [blood urea nitrogen >27] + 0.4574 [Model for End-Stage Liver Disease score >21] + 1.1625 [intensive care unit days >3]). A clinical prediction rule for patients with a score greater than 0.12 was applied to OLTx recipients who underwent transplantation in 2002. A total of 15 of 20 patients who received RRT and 111 of 121 who did not were correctly classified with the model. Conclusions. This model allowed us to identify patients at high risk for developing the need for RRT postoperatively. Strategies for these patients to prevent or ameliorate acute renal failure and reduce the need for RRT postoperatively are needed.",
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T1 - Preoperative and perioperative predictors of the need for renal replacement therapy after orthotopic liver transplantation

AU - Sanchez, Edmund Q.

AU - Gonwa, Thomas A.

AU - Levy, Marlon F.

AU - Goldstein, Robert M.

AU - Mai, Martin

AU - Hays, Steven R.

AU - Melton, Larry B.

AU - Saracino, Giovanna

AU - Klintmalm, Goran B.

PY - 2004/10/15

Y1 - 2004/10/15

N2 - Background. Acute renal failure developing after orthotopic liver transplantation (OLTx) requiring renal replacement heralds a poor prognosis. Our center has previously reported a 1-year survival of only 41.8%. We undertook this study to determine whether we could identify preoperative and perioperative factors that would predict which patients are at risk. Methods. OLTxs performed between January 1, 1996, and December 31, 2001, were included in our retrospective database review. Combined kidney-liver transplants or patients with preoperative renal replacement therapy (RRT) were excluded. A total of 724 OLTxs were studied, which were divided into group I: no RRT, n=637; group II: hemodialysis only post-OLTx, n=17; and group III: continuous RRT post-OLTx, n=70. Univariate and stepwise logistic multivariate analyses were performed. Results. Preoperative serum creatinine greater than 1.9 mg/dL (odds ratio [OR] 3.57), preoperative blood urea nitrogen greater than 27 mg/dL (OR 2.68), intensive care unit stay more than 3 days (OR 10.23), and Model for End-Stage Liver Disease score greater than 21 (OR 2.5) were significant. A clinical prediction model was constructed: probability of requiring dialysis posttransplant=(-2.4586+1.2726 [creatinine >1.9] + 0.9858 [blood urea nitrogen >27] + 0.4574 [Model for End-Stage Liver Disease score >21] + 1.1625 [intensive care unit days >3]). A clinical prediction rule for patients with a score greater than 0.12 was applied to OLTx recipients who underwent transplantation in 2002. A total of 15 of 20 patients who received RRT and 111 of 121 who did not were correctly classified with the model. Conclusions. This model allowed us to identify patients at high risk for developing the need for RRT postoperatively. Strategies for these patients to prevent or ameliorate acute renal failure and reduce the need for RRT postoperatively are needed.

AB - Background. Acute renal failure developing after orthotopic liver transplantation (OLTx) requiring renal replacement heralds a poor prognosis. Our center has previously reported a 1-year survival of only 41.8%. We undertook this study to determine whether we could identify preoperative and perioperative factors that would predict which patients are at risk. Methods. OLTxs performed between January 1, 1996, and December 31, 2001, were included in our retrospective database review. Combined kidney-liver transplants or patients with preoperative renal replacement therapy (RRT) were excluded. A total of 724 OLTxs were studied, which were divided into group I: no RRT, n=637; group II: hemodialysis only post-OLTx, n=17; and group III: continuous RRT post-OLTx, n=70. Univariate and stepwise logistic multivariate analyses were performed. Results. Preoperative serum creatinine greater than 1.9 mg/dL (odds ratio [OR] 3.57), preoperative blood urea nitrogen greater than 27 mg/dL (OR 2.68), intensive care unit stay more than 3 days (OR 10.23), and Model for End-Stage Liver Disease score greater than 21 (OR 2.5) were significant. A clinical prediction model was constructed: probability of requiring dialysis posttransplant=(-2.4586+1.2726 [creatinine >1.9] + 0.9858 [blood urea nitrogen >27] + 0.4574 [Model for End-Stage Liver Disease score >21] + 1.1625 [intensive care unit days >3]). A clinical prediction rule for patients with a score greater than 0.12 was applied to OLTx recipients who underwent transplantation in 2002. A total of 15 of 20 patients who received RRT and 111 of 121 who did not were correctly classified with the model. Conclusions. This model allowed us to identify patients at high risk for developing the need for RRT postoperatively. Strategies for these patients to prevent or ameliorate acute renal failure and reduce the need for RRT postoperatively are needed.

KW - Liver transplantation

KW - Renal failure

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