Prenatal or Perinatal Injury? Diagnosing the Cortically Blind Infant

Mai Lan Ho, Sasha A. Mansukhani, Michael C. Brodsky

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Purpose: To document the association of prenatal brain disruption with secondary perinatal distress in children diagnosed as having cortical visual impairment (CVI). Design: Retrospective case series. Methods: Eight children with severe CVI and clinical history of perinatal events were included. Case histories and neuroimaging studies were reviewed. The main outcome measures were perinatal history, visual and neurologic findings, and magnetic resonance (MR) imaging. Results: In our patient cohort, MR imaging showed signs of cortical dysgenesis leading to congenital brain malformations such as polymicrogyria consistent with a prenatal timing of CNS injury. Although subcortical white matter changes were common, signs of watershed injury to the visual cortex were absent, suggesting that the visual loss was attributable to a prenatal etiology with secondary birth complications. Conclusion: Some children with CVI and a history of perinatal distress have prenatal dysgenesis of the developing brain. Therefore, a clinical history of perinatal hypoxia-ischemia is nonspecific and merits neuroimaging to identify antecedent brain malformations and timing of injury, which can influence patient diagnosis and management.

Original languageEnglish (US)
Pages (from-to)56-62
Number of pages7
JournalAmerican journal of ophthalmology
Volume211
DOIs
StatePublished - Mar 2020

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Prenatal or Perinatal Injury? Diagnosing the Cortically Blind Infant'. Together they form a unique fingerprint.

Cite this