Prematurity and fetal lung response after tracheal occlusion in fetuses with severe congenital diaphragmatic hernia

Nicolas Sananes, Carlota Rodo, Jose Luis Peiro, Ingrid Schwach Werneck Britto, Haleh Sangi-Haghpeykar, Romain Favre, Arnaud Joal, Adrien Gaudineau, Marcos Marques da Silva, Uenis Tannuri, Marcelo Zugaib, Elena Carreras, Rodrigo Ruano

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To evaluate the independent association of fetal pulmonary response and prematurity to postnatal outcomes after fetal tracheal occlusion for congenital diaphragmatic hernia. Methods: Fetal pulmonary response, prematurity (<37 weeks at delivery) and extreme prematurity (<32 weeks at delivery) were evaluated and compared between survivors and non-survivors at 6 months of life. Multivariable analysis was conducted with generalized linear mixed models for variables significantly associated with survival in univariate analysis. Results: Eighty-four infants were included, of whom 40 survived (47.6%) and 44 died (52.4%). Univariate analysis demonstrated that survival was associated with greater lung response (p=0.006), and the absence of extreme preterm delivery (p=0.044). In multivariable analysis, greater pulmonary response after FETO was an independent predictor of survival (aOR 1.87, 95% CI 1.08–3.33, p=0.023), whereas the presence of extreme prematurity was not statistically associated with mortality after controlling for fetal pulmonary response (aOR 0.52, 95% CI 0.12–2.30, p=0.367). Conclusion: Fetal pulmonary response after FETO is the most important factor associated with survival, independently from the gestational age at delivery.

Original languageEnglish (US)
Pages (from-to)3030-3034
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume29
Issue number18
DOIs
StatePublished - Sep 16 2016
Externally publishedYes

Fingerprint

Fetus
Lung
Survival
Survival Analysis
Gestational Age
Survivors
Congenital Diaphragmatic Hernias
Linear Models
Mortality

Keywords

  • Congenital diaphragmatic hernia
  • fetal lung
  • fetal surgery
  • fetoscopy
  • lung-to-head ratio
  • prematurity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Prematurity and fetal lung response after tracheal occlusion in fetuses with severe congenital diaphragmatic hernia. / Sananes, Nicolas; Rodo, Carlota; Peiro, Jose Luis; Britto, Ingrid Schwach Werneck; Sangi-Haghpeykar, Haleh; Favre, Romain; Joal, Arnaud; Gaudineau, Adrien; Silva, Marcos Marques da; Tannuri, Uenis; Zugaib, Marcelo; Carreras, Elena; Ruano, Rodrigo.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 29, No. 18, 16.09.2016, p. 3030-3034.

Research output: Contribution to journalArticle

Sananes, N, Rodo, C, Peiro, JL, Britto, ISW, Sangi-Haghpeykar, H, Favre, R, Joal, A, Gaudineau, A, Silva, MMD, Tannuri, U, Zugaib, M, Carreras, E & Ruano, R 2016, 'Prematurity and fetal lung response after tracheal occlusion in fetuses with severe congenital diaphragmatic hernia', Journal of Maternal-Fetal and Neonatal Medicine, vol. 29, no. 18, pp. 3030-3034. https://doi.org/10.3109/14767058.2015.1114080
Sananes, Nicolas ; Rodo, Carlota ; Peiro, Jose Luis ; Britto, Ingrid Schwach Werneck ; Sangi-Haghpeykar, Haleh ; Favre, Romain ; Joal, Arnaud ; Gaudineau, Adrien ; Silva, Marcos Marques da ; Tannuri, Uenis ; Zugaib, Marcelo ; Carreras, Elena ; Ruano, Rodrigo. / Prematurity and fetal lung response after tracheal occlusion in fetuses with severe congenital diaphragmatic hernia. In: Journal of Maternal-Fetal and Neonatal Medicine. 2016 ; Vol. 29, No. 18. pp. 3030-3034.
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