TY - JOUR
T1 - Premature ovarian insufficiency
AU - Kapoor, Ekta
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/2
Y1 - 2023/2
N2 - Natural menopause typically occurs between the ages of 46–55 years. Premature ovarian insufficiency or premature menopause results from compromised ovarian follicular activity, occurring spontaneously or because of medical interventions, prior to the age of 40 years. The premature loss of estrogen leads to bothersome menopause symptoms and predisposes the women to multiple long-term health risks including a higher mortality risk. Hormone replacement therapy used until the natural age of menopause can help manage the symptoms effectively, and can mitigate the long-term risk of estrogen deprivation. However, hormone replacement therapy is underutilized in this population due to the inappropriate extrapolation of potential risks observed with hormone therapy use in women after natural menopause. There is a large unmet need for educating patients and providers regarding the impact of premature ovarian insufficiency and its appropriate management.
AB - Natural menopause typically occurs between the ages of 46–55 years. Premature ovarian insufficiency or premature menopause results from compromised ovarian follicular activity, occurring spontaneously or because of medical interventions, prior to the age of 40 years. The premature loss of estrogen leads to bothersome menopause symptoms and predisposes the women to multiple long-term health risks including a higher mortality risk. Hormone replacement therapy used until the natural age of menopause can help manage the symptoms effectively, and can mitigate the long-term risk of estrogen deprivation. However, hormone replacement therapy is underutilized in this population due to the inappropriate extrapolation of potential risks observed with hormone therapy use in women after natural menopause. There is a large unmet need for educating patients and providers regarding the impact of premature ovarian insufficiency and its appropriate management.
KW - Hormone replacement therapy
KW - Premature menopause
KW - Primary ovarian insufficiency
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U2 - 10.1016/j.coemr.2023.100435
DO - 10.1016/j.coemr.2023.100435
M3 - Review article
AN - SCOPUS:85148376792
SN - 2451-9650
VL - 28
JO - Current Opinion in Endocrine and Metabolic Research
JF - Current Opinion in Endocrine and Metabolic Research
M1 - 100435
ER -