Preliminary pneumoperitoneum facilitates transgastric access into the peritoneal cavity for natural orifice transluminal endoscopic surgery

A pilot study in a live porcine model

C. W. Ko, E. J. Shin, J. M. Buscaglia, J. O. Clarke, P. Magno, S. A. Giday, S. S C Chung, P. B. Cotton, C. J. Gostout, R. H. Hawes, P. J. Pasricha, A. N. Kalloo, S. V. Kantsevoy

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background and study aims: Safe entrance into the peritoneal cavity through the gastric wall is paramount for the successful clinical introduction of natural orifice transluminal endoscopic surgery (NOTES). The aim of the study was to develop alternative safe transgastric access to the peritoneal cavity. Patients and methods: We performed 11 survival experiments on 50-kg pigs. In sterile conditions, the abdominal wall was punctured with a Veress needle. The peritoneal cavity was insufflated with 2 L carbon dioxide (CO2. A sterile endoscope was introduced into the stomach through a sterile overtube; the gastric wall was punctured with a needle-knife; after balloon dilation of the puncture site, the endoscope was advanced into the peritoneal cavity. Peritoneoscopy with biopsies from abdominal wall, liver and omentum, was performed. The endoscope was withdrawn into the stomach. The animals were kept alive for 2 weeks and repeat endoscopy was followed by necropsy. Results: The pneumoperitoneum, easily created with the Veress needle, lifted the abdominal wall and made a CO2-filled space between the stomach and adjacent organs, facilitating gastric wall puncture and advancement of the endoscope into the peritoneal cavity. There were no hemodynamic changes or immediate or delayed complications related to pneumoperitoneum, transgastric access, or intraperitoneal manipulations. Follow-up endoscopy and necropsy revealed no problems or complications inside the stomach or peritoneal cavity. Conclusions: Creation of a preliminary pneumoperitoneum with a Veress needle facilitates gastric wall puncture and entrance into the peritoneal cavity without injury to adjacent organs, and can improve the safety of NOTES.

Original languageEnglish (US)
Pages (from-to)849-853
Number of pages5
JournalEndoscopy
Volume39
Issue number10
DOIs
StatePublished - Oct 2007

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Natural Orifice Endoscopic Surgery
Pneumoperitoneum
Peritoneal Cavity
Stomach
Swine
Endoscopes
Needles
Abdominal Wall
Punctures
Endoscopy
Omentum
Carbon Dioxide
Laparoscopy
Dilatation
Hemodynamics
Biopsy
Safety
Survival

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Preliminary pneumoperitoneum facilitates transgastric access into the peritoneal cavity for natural orifice transluminal endoscopic surgery : A pilot study in a live porcine model. / Ko, C. W.; Shin, E. J.; Buscaglia, J. M.; Clarke, J. O.; Magno, P.; Giday, S. A.; Chung, S. S C; Cotton, P. B.; Gostout, C. J.; Hawes, R. H.; Pasricha, P. J.; Kalloo, A. N.; Kantsevoy, S. V.

In: Endoscopy, Vol. 39, No. 10, 10.2007, p. 849-853.

Research output: Contribution to journalArticle

Ko, CW, Shin, EJ, Buscaglia, JM, Clarke, JO, Magno, P, Giday, SA, Chung, SSC, Cotton, PB, Gostout, CJ, Hawes, RH, Pasricha, PJ, Kalloo, AN & Kantsevoy, SV 2007, 'Preliminary pneumoperitoneum facilitates transgastric access into the peritoneal cavity for natural orifice transluminal endoscopic surgery: A pilot study in a live porcine model', Endoscopy, vol. 39, no. 10, pp. 849-853. https://doi.org/10.1055/s-2007-966844
Ko, C. W. ; Shin, E. J. ; Buscaglia, J. M. ; Clarke, J. O. ; Magno, P. ; Giday, S. A. ; Chung, S. S C ; Cotton, P. B. ; Gostout, C. J. ; Hawes, R. H. ; Pasricha, P. J. ; Kalloo, A. N. ; Kantsevoy, S. V. / Preliminary pneumoperitoneum facilitates transgastric access into the peritoneal cavity for natural orifice transluminal endoscopic surgery : A pilot study in a live porcine model. In: Endoscopy. 2007 ; Vol. 39, No. 10. pp. 849-853.
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abstract = "Background and study aims: Safe entrance into the peritoneal cavity through the gastric wall is paramount for the successful clinical introduction of natural orifice transluminal endoscopic surgery (NOTES). The aim of the study was to develop alternative safe transgastric access to the peritoneal cavity. Patients and methods: We performed 11 survival experiments on 50-kg pigs. In sterile conditions, the abdominal wall was punctured with a Veress needle. The peritoneal cavity was insufflated with 2 L carbon dioxide (CO2. A sterile endoscope was introduced into the stomach through a sterile overtube; the gastric wall was punctured with a needle-knife; after balloon dilation of the puncture site, the endoscope was advanced into the peritoneal cavity. Peritoneoscopy with biopsies from abdominal wall, liver and omentum, was performed. The endoscope was withdrawn into the stomach. The animals were kept alive for 2 weeks and repeat endoscopy was followed by necropsy. Results: The pneumoperitoneum, easily created with the Veress needle, lifted the abdominal wall and made a CO2-filled space between the stomach and adjacent organs, facilitating gastric wall puncture and advancement of the endoscope into the peritoneal cavity. There were no hemodynamic changes or immediate or delayed complications related to pneumoperitoneum, transgastric access, or intraperitoneal manipulations. Follow-up endoscopy and necropsy revealed no problems or complications inside the stomach or peritoneal cavity. Conclusions: Creation of a preliminary pneumoperitoneum with a Veress needle facilitates gastric wall puncture and entrance into the peritoneal cavity without injury to adjacent organs, and can improve the safety of NOTES.",
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AU - Ko, C. W.

AU - Shin, E. J.

AU - Buscaglia, J. M.

AU - Clarke, J. O.

AU - Magno, P.

AU - Giday, S. A.

AU - Chung, S. S C

AU - Cotton, P. B.

AU - Gostout, C. J.

AU - Hawes, R. H.

AU - Pasricha, P. J.

AU - Kalloo, A. N.

AU - Kantsevoy, S. V.

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N2 - Background and study aims: Safe entrance into the peritoneal cavity through the gastric wall is paramount for the successful clinical introduction of natural orifice transluminal endoscopic surgery (NOTES). The aim of the study was to develop alternative safe transgastric access to the peritoneal cavity. Patients and methods: We performed 11 survival experiments on 50-kg pigs. In sterile conditions, the abdominal wall was punctured with a Veress needle. The peritoneal cavity was insufflated with 2 L carbon dioxide (CO2. A sterile endoscope was introduced into the stomach through a sterile overtube; the gastric wall was punctured with a needle-knife; after balloon dilation of the puncture site, the endoscope was advanced into the peritoneal cavity. Peritoneoscopy with biopsies from abdominal wall, liver and omentum, was performed. The endoscope was withdrawn into the stomach. The animals were kept alive for 2 weeks and repeat endoscopy was followed by necropsy. Results: The pneumoperitoneum, easily created with the Veress needle, lifted the abdominal wall and made a CO2-filled space between the stomach and adjacent organs, facilitating gastric wall puncture and advancement of the endoscope into the peritoneal cavity. There were no hemodynamic changes or immediate or delayed complications related to pneumoperitoneum, transgastric access, or intraperitoneal manipulations. Follow-up endoscopy and necropsy revealed no problems or complications inside the stomach or peritoneal cavity. Conclusions: Creation of a preliminary pneumoperitoneum with a Veress needle facilitates gastric wall puncture and entrance into the peritoneal cavity without injury to adjacent organs, and can improve the safety of NOTES.

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