Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy)

J. J. Hauw, S. E. Daniel, Dennis W Dickson, D. S. Horoupian, K. Jellinger, P. L. Lantos, A. McKee, M. Tabaton, I. Litvan

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Abstract

We present the preliminary neuropathologic criteria for progressive supranuclear palsy (PSP) as proposed at a workshop held at the National Institutes of Health, Bethesda, MD, April 24 and 25, 1993. The criteria distinguish typical, atypical, and combined PSP. A semiquantitative distribution of neurofibrillary tangles is the basis for the diagnosis of PSP. A high density of neurofibrillary tangles and neuropil threads in the basal ganglia and brainstem is crucial for the diagnosis of typical PSP. Tau- positive astrocytes or their processes in areas of involvement help to confirm the diagnosis. Atypical cases of PSP are variants in which the severity or distribution of abnormalities deviates from the typical pattern. Criteria excluding the diagnosis of typical and atypical PSP are large or numerous infarcts, marked diffuse or focal atrophy, Lewy bodies, changes diagnostic of Alzheimer's disease, oligodendroglial argyrophilic inclusions, Pick bodies, diffuse spongiosis, and prion protein-positive amyloid plaques. The diagnosis of combined PSP is proposed when other neurologic disorders exist concomitantly with PSP.

Original languageEnglish (US)
Pages (from-to)2015-2019
Number of pages5
JournalNeurology
Volume44
Issue number11
StatePublished - Nov 1994
Externally publishedYes

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National Institute of Neurological Disorders and Stroke
Progressive Supranuclear Palsy
Neurofibrillary Tangles
Neuropil Threads
Lewy Bodies
Inclusion Bodies
Amyloid Plaques
National Institutes of Health (U.S.)
Basal Ganglia
Nervous System Diseases
Astrocytes
Brain Stem
Atrophy
Alzheimer Disease
Education
Progressive supranuclear palsy atypical

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hauw, J. J., Daniel, S. E., Dickson, D. W., Horoupian, D. S., Jellinger, K., Lantos, P. L., ... Litvan, I. (1994). Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). Neurology, 44(11), 2015-2019.

Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). / Hauw, J. J.; Daniel, S. E.; Dickson, Dennis W; Horoupian, D. S.; Jellinger, K.; Lantos, P. L.; McKee, A.; Tabaton, M.; Litvan, I.

In: Neurology, Vol. 44, No. 11, 11.1994, p. 2015-2019.

Research output: Contribution to journalArticle

Hauw, JJ, Daniel, SE, Dickson, DW, Horoupian, DS, Jellinger, K, Lantos, PL, McKee, A, Tabaton, M & Litvan, I 1994, 'Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy)', Neurology, vol. 44, no. 11, pp. 2015-2019.
Hauw JJ, Daniel SE, Dickson DW, Horoupian DS, Jellinger K, Lantos PL et al. Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). Neurology. 1994 Nov;44(11):2015-2019.
Hauw, J. J. ; Daniel, S. E. ; Dickson, Dennis W ; Horoupian, D. S. ; Jellinger, K. ; Lantos, P. L. ; McKee, A. ; Tabaton, M. ; Litvan, I. / Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). In: Neurology. 1994 ; Vol. 44, No. 11. pp. 2015-2019.
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