Preintervention arterial remodeling affects vessel stretch and plaque extrusion during coronary stent deployment as demonstrated by three-dimensional intravascular ultrasound

Clemens Von Birgelen, Gary S. Mintz, Holger Eggebrecht, Jörg Herrmann, Matthias Jasper, Jens Brinkhoff, Till Neumann, Dirk Böse, Dietrich Baumgart, Axel Schmermund, Heinrich Wieneke, Michael Haude, Raimund Erbel

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The mechanisms of lumen enlargement during stent implantation may be significantly affected by arterial remodeling. To assess effects of lesion remodeling, we performed 3-dimensional intravascular ultrasound (IVUS) analyses in 55 coronary lesions before and after deployment of balloon-expandable stents. Standard quantitative analysis was performed, and arterial remodeling was assessed by the remodeling index (target site divided by mean of proximal and distal reference segment vessel areas), which classified lesions into group A (remodeling index ≤1, negative or intermediate remodeling, n = 40) or group B (remodeling index >1, positive remodeling, n = 15) lesions. Characteristics of the 55 patients and the interventional procedures were similar in the 2 groups. IVUS demonstrated that stenting resulted in increased lumen and vessel dimensions and in a reduced plaque size (p ≤0.001 each) in both group A and group B lesions. The extent of lumen increase inside the stents was almost identical, but resulted from different mechanisms: (1) vessel stretch was greater in group A (p <0.002 at minimum lumen site); (2) plaque compression (or embolization) tended to be greater in group B (p = 0.05, along entire stented segment); (3) plaque redistribution within the stent was observed in both groups (p <0.005 both); and (4) significant (p <0.01) plaque extrusion into the distal reference segment was found in group B only. Thus, the remodeling pattern of coronary lesions has a significant impact on the mechanisms of lumen enlargement during stent deployment. Lesions with positive remodeling show more plaque extrusion into the distal reference and less stent-induced vessel stretch than those with negative remodeling.

Original languageEnglish (US)
Pages (from-to)130-135
Number of pages6
JournalAmerican Journal of Cardiology
Volume92
Issue number2
DOIs
StatePublished - Jul 15 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Preintervention arterial remodeling affects vessel stretch and plaque extrusion during coronary stent deployment as demonstrated by three-dimensional intravascular ultrasound'. Together they form a unique fingerprint.

  • Cite this

    Von Birgelen, C., Mintz, G. S., Eggebrecht, H., Herrmann, J., Jasper, M., Brinkhoff, J., Neumann, T., Böse, D., Baumgart, D., Schmermund, A., Wieneke, H., Haude, M., & Erbel, R. (2003). Preintervention arterial remodeling affects vessel stretch and plaque extrusion during coronary stent deployment as demonstrated by three-dimensional intravascular ultrasound. American Journal of Cardiology, 92(2), 130-135. https://doi.org/10.1016/S0002-9149(03)00526-5