TY - JOUR
T1 - Prehospital amiodarone may increase the incidence of acute respiratory distress syndrome among patients at risk
AU - Karnatovskaia, Lioudmila V.
AU - Festic, Emir
AU - Gajic, Ognjen
AU - Carter, Rickey E.
AU - Lee, Augustine S.
AU - Ahmed, Adil
AU - Gajic, Ognjen
AU - Malinchoc, Michael
AU - Kor, Daryl J.
AU - Afessa, Bekele
AU - Cartin-Ceba, Rodrigo
AU - Dabbagh, Ousama
AU - Nagam, Nivedita
AU - Patel, Shilpa
AU - Karo, Ammar
AU - Hess, Brian
AU - Park, Pauline K.
AU - Harris, Julie
AU - Napolitano, Lena
AU - Raghavendran, Krishnan
AU - Hyzy, Robert C.
AU - Blum, James
AU - Dean, Christy
AU - Adesanya, Adebola
AU - Hosur, Srikanth
AU - Enoh, Victor
AU - Chang, Steven Y.
AU - Patrawalla, Amee
AU - Elie, Marie
AU - Hou, Peter C.
AU - Barry, Jonathan M.
AU - Shempp, Ian
AU - Malhotra, Atul
AU - Frendl, Gyorgy Y.
AU - Anderson, Harry
AU - Tchorz, Kathryn
AU - McCarthy, Mary C.
AU - Uddin, David
AU - Hoth, James Jason
AU - Yoza, Barbara
AU - Mikkelsen, Mark
AU - Christie, Jason D.
AU - Gaieski, David F.
AU - Lanken, Paul
AU - Meyer, Nuala
AU - Shah, Chirag
AU - Gentile, Nina T.
AU - Stevenson, Karen
AU - Freeman, Brent
AU - Srinivasan, Sujatha
AU - Gong, Michelle Ng
AU - Talmor, Daniel
AU - Bender, Stephen Patrick
AU - Garcia, Mauricio
AU - Bajwa, Ednan
AU - Malhotra, Atul
AU - Thompson, Boyd Taylor
AU - Christiani, David C.
AU - Watkins, Timothy R.
AU - Deem, Steven
AU - Treggiari, Miriam
AU - Festic, Emir
AU - Daniels, John
AU - Cengiz, Melike
AU - Yilmaz, Murat
AU - Iscimen, Remzi
AU - Kaufman, David
AU - Esper, Annette
AU - Martin, Greg
AU - Sadikot, Ruxana
AU - Douglas, Ivor
AU - Sevransky, Jonathan
N1 - Funding Information:
The following are the USCIITG-LIPS1 participating centers and corresponding investigators: Mayo Clinic, Rochester, Minn: Adil Ahmed, MD; Ognjen Gajic, MD; Michael Malinchoc, MS; Daryl J. Kor, MD; Bekele Afessa, MD; Rodrigo Cartin-Ceba, MD; Departments of Internal Medicine, Pulmonary and Critical Care Medicine, Health Sciences Research, and Anesthesiology University of Missouri, Columbia: Ousama Dabbagh, MD, MSPH, Associate Professor of Clinical Medicine; Nivedita Nagam, MD; Shilpa Patel, MD; Ammar Karo and Brian Hess University of Michigan, Ann Arbor: Pauline K. Park, MD, FACS, FCCS, Codirector, Surgical Intensive Care Unit, Associate Professor, Surgery; Julie Harris, Clinical Research Coordinator; Lena Napolitano, MD; Krishnan Raghavendran, MBBS; Robert C. Hyzy, MD; James Blum, MD; Christy Dean University of Texas Southwestern Medical Center in Dallas, Tex: Adebola Adesanya, MD; Srikanth Hosur, MD; Victor Enoh, MD; Department of Anesthesiology, Division of Critical Care Medicine University of Medicine and Dentistry of New Jersey: Steven Y. Chang, PhD, MD, Assistant Professor, MICU Director, Pulmonary and Critical Care Medicine; Amee Patrawalla, MD, MPH; Marie Elie, MD Brigham and Women's Hospital: Peter C. Hou, MD; Jonathan M. Barry, BA; Ian Shempp, BS; Atul Malhotra, MD; Gyorgy Frendl, MD, PhD; Departments of Emergency Medicine, Surgery, Internal Medicine and Anesthesiology Perioperative and Pain Medicine, Division of Burn, Trauma, and Surgical Critical Care Wright State University Boonshoft School of Medicine and Miami Valley Hospital: Harry Anderson III, MD, Professor of Surgery; Kathryn Tchorz, MD, Associate Professor of Surgery; Mary C. McCarthy, MD, Professor of Surgery; David Uddin, PhD, DABCC, CIP, Director of Research Wake Forest University Health Sciences, Winston-Salem, NC: James Jason Hoth, MD, Assistant Professor of Surgery; Barbara Yoza, PhD, Study Coordinator University of Pennsylvania: Mark Mikkelsen, MD, MSCE, Assistant Professor of Medicine, Pulmonary, Allergy and Critical Care Division; Jason D. Christie, MD; David F. Gaieski, MD; Paul Lanken, MD; Nuala Meyer, MD; Chirag Shah, MD Temple University School of Medicine: Nina T. Gentile, MD, Associate Professor and Director, Clinical Research; Karen Stevenson, MD; Brent Freeman, BS, Research Coordinator; Sujatha Srinivasan, MD, Department of Emergency Medicine Mount Sinai School of Medicine: Michelle Ng Gong, MD, MS, Assistant Professor, Pulmonary, Critical Care and Sleep Medicine, Department of Medicine Beth Israel Deaconess Medical Center, Boston, Mass: Daniel Talmor, MD, Director of Anesthesia and Critical Care, Associate Professor of Anesthesia, Harvard Medical School; Stephen Patrick Bender, MD; Mauricio Garcia, MD Massachusetts General Hospital Harvard Medical School: Ednan Bajwa, MD, MPH, Instructor in Medicine; Atul Malhotra, MD, Assistant Professor; Boyd Taylor Thompson, MD, Associate Professor; David C. Christiani, MD, MPH, Professor University of Washington, Harborview: Timothy R. Watkins, MD, Acting Instructor, Department of Medicine, Division of Pulmonary and Critical Care Medicine; Steven Deem, MD; Miriam Treggiari, MD, MPH Mayo Clinic Jacksonville: Emir Festic, MD; Augustine Lee, MD; John Daniels, MD Akdeniz University, Antalyia, Turkey: Melike Cengiz, MD, PhD; Murat Yilmaz, MD Uludag University, Bursa, Turkey: Remzi Iscimen, MD Bridgeport Hospital Yale New Haven Health: David Kaufman, MD, Section Chief, Pulmonary, Critical Care and Sleep Medicine, Medical Director, Respiratory Therapy Emory University: Annette Esper, MD; Greg Martin, MD University of Illinois at Chicago: Ruxana Sadikot, MD, MRCP University of Colorado: Ivor Douglas, MD Johns Hopkins University: Jonathan Sevransky, MD, MHS, Assistant Professor of Medicine, Medical Director, JHBMC MICU We would also like to acknowledge the help and support of Rob Taylor (Vanderbilt University, Nashville, Tex) and Joseph J. Wick (Mayo Clinic) for the availability and maintenance of REDcap database.
PY - 2012/10/1
Y1 - 2012/10/1
N2 - Purpose: Amiodarone has been implicated as a risk factor for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) when used in the hospital. This study aims to estimate whether prehospital amiodarone also increases the risk of ALI/ARDS. Materials: Adult patients admitted to 22 centers with at least 1 risk factor for developing ALI were recruited. In a secondary analysis of this cohort, the prehospital use of amiodarone was documented on admission, and the patients followed for the primary outcome of ALI and secondary outcomes of ARDS, the need for invasive ventilation, and mortality. Dose/duration of amiodarone therapy was not available. Propensity matching was performed to account for imbalances in being assigned to amiodarone. The adjusted risk for ALI/ARDS was then estimated from a conditional logistic regression model of this propensity-matched set. Results: Forty of 5584 patients were on amiodarone at the time of hospitalization; of those, 6 developed ALI, with 5 progressing to ARDS. In comparison, 371 patients not on amiodarone developed ALI, with 224 having ARDS. After propensity score matching, the prehospital use of amiodarone was not statistically associated with an increased risk for all ALI (odds ratio [OR], 1.8; 95% confidence interval [CI], 0.7-5.0; P = .25), invasive ventilation (OR, 1.9; 95% CI, 1.0-3.6; P = .059), or in-hospital mortality (OR, 1.2; 95% CI, 0.5-2.9; P = .75); but its use appeared to significantly increase the risk for ARDS (OR 3.8; 95% CI, 1.1-13.1; P = .036). Conclusions: Prehospital use of amiodarone may independently increase the risk for ARDS in patients who have at least 1 predisposing condition for ALI.
AB - Purpose: Amiodarone has been implicated as a risk factor for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) when used in the hospital. This study aims to estimate whether prehospital amiodarone also increases the risk of ALI/ARDS. Materials: Adult patients admitted to 22 centers with at least 1 risk factor for developing ALI were recruited. In a secondary analysis of this cohort, the prehospital use of amiodarone was documented on admission, and the patients followed for the primary outcome of ALI and secondary outcomes of ARDS, the need for invasive ventilation, and mortality. Dose/duration of amiodarone therapy was not available. Propensity matching was performed to account for imbalances in being assigned to amiodarone. The adjusted risk for ALI/ARDS was then estimated from a conditional logistic regression model of this propensity-matched set. Results: Forty of 5584 patients were on amiodarone at the time of hospitalization; of those, 6 developed ALI, with 5 progressing to ARDS. In comparison, 371 patients not on amiodarone developed ALI, with 224 having ARDS. After propensity score matching, the prehospital use of amiodarone was not statistically associated with an increased risk for all ALI (odds ratio [OR], 1.8; 95% confidence interval [CI], 0.7-5.0; P = .25), invasive ventilation (OR, 1.9; 95% CI, 1.0-3.6; P = .059), or in-hospital mortality (OR, 1.2; 95% CI, 0.5-2.9; P = .75); but its use appeared to significantly increase the risk for ARDS (OR 3.8; 95% CI, 1.1-13.1; P = .036). Conclusions: Prehospital use of amiodarone may independently increase the risk for ARDS in patients who have at least 1 predisposing condition for ALI.
KW - Acute lung injury
KW - Acute respiratory distress syndrome
KW - Amiodarone
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U2 - 10.1016/j.jcrc.2011.10.009
DO - 10.1016/j.jcrc.2011.10.009
M3 - Article
C2 - 22226422
AN - SCOPUS:84867328337
SN - 0883-9441
VL - 27
SP - 447
EP - 453
JO - Journal of Critical Care
JF - Journal of Critical Care
IS - 5
ER -