Pregnancy outcome after magnetic resonance-guided focused ultrasound surgery (MRgFUS) for conservative treatment of uterine fibroids

Jaron Rabinovici, Matthias David, Hidenobu Fukunishi, Yutaka Morita, Bobbie S. Gostout, Elizabeth A Stewart

Research output: Contribution to journalArticle

156 Scopus citations

Abstract

Objective: To report all pregnancies to date after magnetic resonance-guided focused ultrasound surgery (MRgFUS) for the conservative treatment of clinically significant uterine fibroids. Design: Prospective registry of all known pregnancies occurring after MRgFUS maintained by the device manufacturer and reported to the Food and Drug Administration. Setting: World experience of pregnancies after treatment with reports from 13 sites in seven countries. Patient(s): Fifty-one reproductive-age women with uterine leiomyomas. Intervention(s): Women underwent MRgFUS treatment for symptomatic uterine leiomyomas before this report. Main Outcome Measure(s): Pregnancy outcomes and complications. Result(s): Fifty-four pregnancies in 51 women have occurred after MRgFUS treatment of uterine leiomyomas. The mean time to conception was 8 months after treatment. Live births occurred in 41% of pregnancies, with a 28% spontaneous abortion rate, an 11% rate of elective pregnancy termination, and 11 (20%) ongoing pregnancies beyond 20 gestational weeks. The mean birth weight was 3.3 kg, and the vaginal delivery rate was 64%. Conclusion(s): Preliminary pregnancy experience after MRgFUS is encouraging, with a high rate of delivered and ongoing pregnancies.

Original languageEnglish (US)
Pages (from-to)199-209
Number of pages11
JournalFertility and Sterility
Volume93
Issue number1
DOIs
StatePublished - Jan 1 2010

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Keywords

  • fibroid
  • leiomyoma
  • myomectomy
  • pregnancy
  • ultrasound
  • Uterus

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

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