Pregnancy history, coronary artery calcification and bone mineral density in menopausal women

J. P. Beckman, J. J. Camp, B. D. Lahr, Kent R Bailey, A. E. Kearns, Vesna D Garovic, M. Jayachandran, Virginia M Miller, David R. Holmes III

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: This study examined relationships, by pregnancy histories, between bone mineral density (BMD) and coronary artery calcification (CAC) in postmenopausal women. Methods: Forty women identified from their medical record as having pre-eclampsia (PE) were age/parity-matched with 40 women having a normotensive pregnancy (NP). Vertebral (T4–9) BMD and CAC were assessed by quantitative computed tomography in 73 (37 with PE and 36 with NP) of the 80 women. Analyses included linear regression using generalized estimating equations. Results: Women averaged 59 years of age and 35 years from the index pregnancy. There were no significant differences in cortical, trabecular or central BMD between groups. CAC was significantly greater in the PE group (p = 0.026). In multivariable analysis, CAC was positively associated with cortical BMD (p = 0.001) and negatively associated with central BMD (p = 0.036). There was a borderline difference in the association between CAC and central BMD by pregnancy history (interaction, p = 0.057). Conclusions: Although CAC was greater in women with a history of PE, vertebral BMD did not differ between groups. However, both cortical and central BMD were associated with CAC. The central BMD association was marginally different by pregnancy history, suggesting perhaps differences in underlying mechanisms of soft tissue calcification.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalClimacteric
DOIs
StateAccepted/In press - Dec 1 2017

Fingerprint

Reproductive History
Bone Density
Coronary Vessels
Pre-Eclampsia
Pregnancy
Parity
Medical Records
Linear Models
Tomography

Keywords

  • Cardiovascular disease
  • osteoporosis
  • osteoprotegerin
  • postmenopausal
  • pre-eclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Pregnancy history, coronary artery calcification and bone mineral density in menopausal women. / Beckman, J. P.; Camp, J. J.; Lahr, B. D.; Bailey, Kent R; Kearns, A. E.; Garovic, Vesna D; Jayachandran, M.; Miller, Virginia M; Holmes III, David R.

In: Climacteric, 01.12.2017, p. 1-7.

Research output: Contribution to journalArticle

@article{72395972ed9f4b9f99dd8a4ac16f7e15,
title = "Pregnancy history, coronary artery calcification and bone mineral density in menopausal women",
abstract = "Objective: This study examined relationships, by pregnancy histories, between bone mineral density (BMD) and coronary artery calcification (CAC) in postmenopausal women. Methods: Forty women identified from their medical record as having pre-eclampsia (PE) were age/parity-matched with 40 women having a normotensive pregnancy (NP). Vertebral (T4–9) BMD and CAC were assessed by quantitative computed tomography in 73 (37 with PE and 36 with NP) of the 80 women. Analyses included linear regression using generalized estimating equations. Results: Women averaged 59 years of age and 35 years from the index pregnancy. There were no significant differences in cortical, trabecular or central BMD between groups. CAC was significantly greater in the PE group (p = 0.026). In multivariable analysis, CAC was positively associated with cortical BMD (p = 0.001) and negatively associated with central BMD (p = 0.036). There was a borderline difference in the association between CAC and central BMD by pregnancy history (interaction, p = 0.057). Conclusions: Although CAC was greater in women with a history of PE, vertebral BMD did not differ between groups. However, both cortical and central BMD were associated with CAC. The central BMD association was marginally different by pregnancy history, suggesting perhaps differences in underlying mechanisms of soft tissue calcification.",
keywords = "Cardiovascular disease, osteoporosis, osteoprotegerin, postmenopausal, pre-eclampsia",
author = "Beckman, {J. P.} and Camp, {J. J.} and Lahr, {B. D.} and Bailey, {Kent R} and Kearns, {A. E.} and Garovic, {Vesna D} and M. Jayachandran and Miller, {Virginia M} and {Holmes III}, {David R.}",
year = "2017",
month = "12",
day = "1",
doi = "10.1080/13697137.2017.1406910",
language = "English (US)",
pages = "1--7",
journal = "Climacteric",
issn = "1369-7137",
publisher = "Informa Healthcare",

}

TY - JOUR

T1 - Pregnancy history, coronary artery calcification and bone mineral density in menopausal women

AU - Beckman, J. P.

AU - Camp, J. J.

AU - Lahr, B. D.

AU - Bailey, Kent R

AU - Kearns, A. E.

AU - Garovic, Vesna D

AU - Jayachandran, M.

AU - Miller, Virginia M

AU - Holmes III, David R.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Objective: This study examined relationships, by pregnancy histories, between bone mineral density (BMD) and coronary artery calcification (CAC) in postmenopausal women. Methods: Forty women identified from their medical record as having pre-eclampsia (PE) were age/parity-matched with 40 women having a normotensive pregnancy (NP). Vertebral (T4–9) BMD and CAC were assessed by quantitative computed tomography in 73 (37 with PE and 36 with NP) of the 80 women. Analyses included linear regression using generalized estimating equations. Results: Women averaged 59 years of age and 35 years from the index pregnancy. There were no significant differences in cortical, trabecular or central BMD between groups. CAC was significantly greater in the PE group (p = 0.026). In multivariable analysis, CAC was positively associated with cortical BMD (p = 0.001) and negatively associated with central BMD (p = 0.036). There was a borderline difference in the association between CAC and central BMD by pregnancy history (interaction, p = 0.057). Conclusions: Although CAC was greater in women with a history of PE, vertebral BMD did not differ between groups. However, both cortical and central BMD were associated with CAC. The central BMD association was marginally different by pregnancy history, suggesting perhaps differences in underlying mechanisms of soft tissue calcification.

AB - Objective: This study examined relationships, by pregnancy histories, between bone mineral density (BMD) and coronary artery calcification (CAC) in postmenopausal women. Methods: Forty women identified from their medical record as having pre-eclampsia (PE) were age/parity-matched with 40 women having a normotensive pregnancy (NP). Vertebral (T4–9) BMD and CAC were assessed by quantitative computed tomography in 73 (37 with PE and 36 with NP) of the 80 women. Analyses included linear regression using generalized estimating equations. Results: Women averaged 59 years of age and 35 years from the index pregnancy. There were no significant differences in cortical, trabecular or central BMD between groups. CAC was significantly greater in the PE group (p = 0.026). In multivariable analysis, CAC was positively associated with cortical BMD (p = 0.001) and negatively associated with central BMD (p = 0.036). There was a borderline difference in the association between CAC and central BMD by pregnancy history (interaction, p = 0.057). Conclusions: Although CAC was greater in women with a history of PE, vertebral BMD did not differ between groups. However, both cortical and central BMD were associated with CAC. The central BMD association was marginally different by pregnancy history, suggesting perhaps differences in underlying mechanisms of soft tissue calcification.

KW - Cardiovascular disease

KW - osteoporosis

KW - osteoprotegerin

KW - postmenopausal

KW - pre-eclampsia

UR - http://www.scopus.com/inward/record.url?scp=85035762518&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85035762518&partnerID=8YFLogxK

U2 - 10.1080/13697137.2017.1406910

DO - 10.1080/13697137.2017.1406910

M3 - Article

C2 - 29189095

AN - SCOPUS:85035762518

SP - 1

EP - 7

JO - Climacteric

JF - Climacteric

SN - 1369-7137

ER -