Pregnancy

a clue to normal regulation of B lymphopoiesis

Paul W. Kincade, Kay L Medina, Glennda Smithson, Denise C. Scott

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The large-scale production of lymphocytes in the bone marrow reflects a delicate balance between positive and negative regulatory signals. For instance, interleukin 7 (IL-7) provides a positive signal, and appears to be both essential and limiting in the mouse. However, much less is understood concerning the negative molecular signals that may limit the output of lymphocytes. Here, Paul Kincade and colleagues discuss how a chance observation with pregnant mice revealed that sex steroids can act as negative regulators of B lymphopoiesis, and may do so under normal steady-state conditions.

Original languageEnglish (US)
Pages (from-to)539-544
Number of pages6
JournalTrends in Immunology
Volume15
Issue number11
StatePublished - Nov 1994
Externally publishedYes

Fingerprint

Lymphopoiesis
Lymphocytes
Interleukin-7
Pregnancy
Bone Marrow
Steroids
Observation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Kincade, P. W., Medina, K. L., Smithson, G., & Scott, D. C. (1994). Pregnancy: a clue to normal regulation of B lymphopoiesis. Trends in Immunology, 15(11), 539-544.

Pregnancy : a clue to normal regulation of B lymphopoiesis. / Kincade, Paul W.; Medina, Kay L; Smithson, Glennda; Scott, Denise C.

In: Trends in Immunology, Vol. 15, No. 11, 11.1994, p. 539-544.

Research output: Contribution to journalArticle

Kincade, PW, Medina, KL, Smithson, G & Scott, DC 1994, 'Pregnancy: a clue to normal regulation of B lymphopoiesis', Trends in Immunology, vol. 15, no. 11, pp. 539-544.
Kincade PW, Medina KL, Smithson G, Scott DC. Pregnancy: a clue to normal regulation of B lymphopoiesis. Trends in Immunology. 1994 Nov;15(11):539-544.
Kincade, Paul W. ; Medina, Kay L ; Smithson, Glennda ; Scott, Denise C. / Pregnancy : a clue to normal regulation of B lymphopoiesis. In: Trends in Immunology. 1994 ; Vol. 15, No. 11. pp. 539-544.
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