Pregabalin for chemotherapy-induced neuropathy: background and rationale for further study

Mellar Davis, Charles Loprinzi

Research output: Contribution to journalReview articlepeer-review

Abstract

Chemotherapy-induced neuropathy is difficult to manage, and the pain associated with neuropathy is poorly responsive to gabapentin in a randomized trial. Duloxetine is the only drug that has been found to be effective in reducing pain from chemotherapy neuropathy. In this qualitative review, the use of pregabalin for chemotherapy-induced neuropathy is discussed including the rationale and pharmacological reasons why pregabalin should be considered in a large, randomized placebo-controlled trial.

Original languageEnglish (US)
JournalSupportive Care in Cancer
DOIs
StateAccepted/In press - 2022

Keywords

  • Alpha2dellta
  • Calcium channel
  • Chemotherapy
  • Neuropathy
  • Pain
  • Pregabalin

ASJC Scopus subject areas

  • Oncology

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