Preferential initiation at the second AUG of the measles virus F mRNA: A role for the long untranslated region

Toni Cathomen, Christian J. Buchholz, Pius Spielhofer, Roberto Cattaneo

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

In the measles virus fusion (F) mRNA, a 574-bases-long untranslated region (UTR), is followed by three clustered AUGs t codon positions 1 (AUG1), 4 (AUG2), and 15 (AUG3). We established that only translation initiation on AUG1 or AUG2 leads to the synthesis of functional F proteins. In the presence of the UTR translation initiation occurs almost exclusively at AuG2. In its absence, the ribosomes initiate also from AUG1 or AUG3.

Original languageEnglish (US)
Pages (from-to)628-632
Number of pages5
JournalVirology
Volume214
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Untranslated Regions
Measles virus
Messenger RNA
Ribosomes
Codon
Proteins

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Preferential initiation at the second AUG of the measles virus F mRNA : A role for the long untranslated region. / Cathomen, Toni; Buchholz, Christian J.; Spielhofer, Pius; Cattaneo, Roberto.

In: Virology, Vol. 214, No. 2, 1995, p. 628-632.

Research output: Contribution to journalArticle

Cathomen, Toni ; Buchholz, Christian J. ; Spielhofer, Pius ; Cattaneo, Roberto. / Preferential initiation at the second AUG of the measles virus F mRNA : A role for the long untranslated region. In: Virology. 1995 ; Vol. 214, No. 2. pp. 628-632.
@article{cc4120cb24fc4bf2b8418f77ca853514,
title = "Preferential initiation at the second AUG of the measles virus F mRNA: A role for the long untranslated region",
abstract = "In the measles virus fusion (F) mRNA, a 574-bases-long untranslated region (UTR), is followed by three clustered AUGs t codon positions 1 (AUG1), 4 (AUG2), and 15 (AUG3). We established that only translation initiation on AUG1 or AUG2 leads to the synthesis of functional F proteins. In the presence of the UTR translation initiation occurs almost exclusively at AuG2. In its absence, the ribosomes initiate also from AUG1 or AUG3.",
author = "Toni Cathomen and Buchholz, {Christian J.} and Pius Spielhofer and Roberto Cattaneo",
year = "1995",
doi = "10.1006/viro.1995.0075",
language = "English (US)",
volume = "214",
pages = "628--632",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Preferential initiation at the second AUG of the measles virus F mRNA

T2 - A role for the long untranslated region

AU - Cathomen, Toni

AU - Buchholz, Christian J.

AU - Spielhofer, Pius

AU - Cattaneo, Roberto

PY - 1995

Y1 - 1995

N2 - In the measles virus fusion (F) mRNA, a 574-bases-long untranslated region (UTR), is followed by three clustered AUGs t codon positions 1 (AUG1), 4 (AUG2), and 15 (AUG3). We established that only translation initiation on AUG1 or AUG2 leads to the synthesis of functional F proteins. In the presence of the UTR translation initiation occurs almost exclusively at AuG2. In its absence, the ribosomes initiate also from AUG1 or AUG3.

AB - In the measles virus fusion (F) mRNA, a 574-bases-long untranslated region (UTR), is followed by three clustered AUGs t codon positions 1 (AUG1), 4 (AUG2), and 15 (AUG3). We established that only translation initiation on AUG1 or AUG2 leads to the synthesis of functional F proteins. In the presence of the UTR translation initiation occurs almost exclusively at AuG2. In its absence, the ribosomes initiate also from AUG1 or AUG3.

UR - http://www.scopus.com/inward/record.url?scp=0029589519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029589519&partnerID=8YFLogxK

U2 - 10.1006/viro.1995.0075

DO - 10.1006/viro.1995.0075

M3 - Article

C2 - 8553566

AN - SCOPUS:0029589519

VL - 214

SP - 628

EP - 632

JO - Virology

JF - Virology

SN - 0042-6822

IS - 2

ER -