Preferential Initiation at the Second AUG of the Measles Virus F mRNA: A Role for the Long Untranslated Region

Toni Cathomen, Christian J. Buchholz, Pius Spielhofer, Roberto Cattaneo

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In the measles virus fusion (F) mRNA, a 574-bases-long untranslated region (UTR), is followed by three clustered AUGs at codon positions 1 (AUG1), 4 (AUG2), and 15 (AUG3). We established that only translation initiation on AUG1or AUG2leads to the synthesis of functional F proteins. In the presence of the UTR translation initiation occurs almost exclusively at AUG2. In its absence, the ribosomes initiate also from AUG1or AUG3.

Original languageEnglish (US)
Article number70075
Pages (from-to)628-632
Number of pages5
Issue number2
StatePublished - Dec 20 1995


ASJC Scopus subject areas

  • Virology

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