TY - JOUR
T1 - Preferential Initiation at the Second AUG of the Measles Virus F mRNA
T2 - A Role for the Long Untranslated Region
AU - Cathomen, Toni
AU - Buchholz, Christian J.
AU - Spielhofer, Pius
AU - Cattaneo, Roberto
N1 - Funding Information:
We thank Martin A. Billeter for discussions and continuous support, Hans Weber and Karin Kaelin for critical review of the manuscript, Frank Radecke for computer assistance, Knut Baczko for communicating unpublished results, Gudrun Christiansen for sequencing, and Fritz Ochsenbein for the photographs. This work was supported by Grants 31-33746.92 and 31-29343.90 of the Schweizerische Nationalfonds and by the Kanton of Zürich.
PY - 1995/12/20
Y1 - 1995/12/20
N2 - In the measles virus fusion (F) mRNA, a 574-bases-long untranslated region (UTR), is followed by three clustered AUGs at codon positions 1 (AUG1), 4 (AUG2), and 15 (AUG3). We established that only translation initiation on AUG1or AUG2leads to the synthesis of functional F proteins. In the presence of the UTR translation initiation occurs almost exclusively at AUG2. In its absence, the ribosomes initiate also from AUG1or AUG3.
AB - In the measles virus fusion (F) mRNA, a 574-bases-long untranslated region (UTR), is followed by three clustered AUGs at codon positions 1 (AUG1), 4 (AUG2), and 15 (AUG3). We established that only translation initiation on AUG1or AUG2leads to the synthesis of functional F proteins. In the presence of the UTR translation initiation occurs almost exclusively at AUG2. In its absence, the ribosomes initiate also from AUG1or AUG3.
UR - http://www.scopus.com/inward/record.url?scp=0029589519&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029589519&partnerID=8YFLogxK
U2 - 10.1006/viro.1995.0075
DO - 10.1006/viro.1995.0075
M3 - Article
C2 - 8553566
AN - SCOPUS:0029589519
SN - 0042-6822
VL - 214
SP - 628
EP - 632
JO - Virology
JF - Virology
IS - 2
M1 - 70075
ER -